Synthesis and biological evaluation of N-substituted benzo[c] phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2117-2131

  Genès, Constance ^a   Lenglet, Gaëlle ^b   Depauw, Sabine ^b   Nhili, Raja ^b   Prado, Soizic ^a   David Cordonnier, Marie Hélène ^b   Michel, Sylvie ^a   Tillequin, François ^a   Porée, François Hugues ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b JEAN PIERRE AUBERT RESEARCH CENTER   (France)

Author keywords

Benzo c phenanthrolines; Benzo c phenanthrolinones; Cytotoxicity; Dialkylaminoalkyl side chains; DNA interactions

Indexed keywords

5 [2' (DIETHYLAMINO)ETHYL] 8,9 DIMETHOXY BENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIETHYLAMINO)ETHYL] 8,9 DIMETHOXY BENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIETHYLAMINO)ETHYL] 8,9 METHYLENE DIOXYBENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIETHYLAMINO)ETHYL] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIMETHYLAMINO)ETHYL] 8,9 DIMETHOXY BENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIMETHYLAMINO)ETHYL] 8,9 DIMETHOXY BENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIMETHYLAMINO)ETHYL] 8,9 METHYLENE DIOXYBENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 5 [2' (DIMETHYLAMINO)ETHYL] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [3' (DIMETHYLAMINO)ETHYL] 8,9 DIMETHOXY BENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [3' (DIMETHYLAMINO)PROPYL] 8,9 METHYLENE DIOXYBENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 5 [3' (DIMETHYLAMINO)PROPYL] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLIN 6(5H) ONE; 5 [3' (DIMETHYLAMINO)PROPYYL] 8,9 DIMETHOXY BENZO[C][1,7]PHENANTHROLIN 6(5H) ONE; 6 [(2' (DIMETHYLAMINO)ETHYL)AMINO] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLINE; 6 [(2' (DIMETHYLAMINO)PROPYL)AMINO] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLINE; 6 [(3' (DIMETHYLAMINO)PROPYL)AMINO] 8,9 DIMETHOXYBENZO[C][1,7]PHENANTHROLINE; 6 [(3' (DIMETHYLAMINO)PROPYL)AMINO] 8,9 DIMETHOXYBENZO[C][1,8]PHENANTHROLINE; 6 [(3' (DIMETHYLAMINO)PROPYL)AMINO] 8,9 METHYLENE DIOXYBENZO[C][1,8]PHENANTHROLINE; 6 [(3' (DIMETHYLAMINO)PROPYL)AMINO] 8,9 METHYLENEDIOXYBENZO[C][1,8]PHENANTHROLINE; 6 CHLORO 8,9 DIMETHOXYBENZO[C][1,7] PHENANTHROLINE; 6 CHLORO 8,9 DIMETHOXYBENZO[C][1,8] PHENANTHROLINE; 6 CHLORO 8,9 METHYLENEDIOXYBENZO[C][1,7] PHENANTHROLINE; 6 CHLORO 8,9 METHYLENEDIOXYBENZO[C][1,8] PHENANTHROLINE; ANTINEOPLASTIC AGENT; BENZO[C]PHENANTHROLINE DERIVATIVE; BENZO[C]PHENANTHROLINONE DERIVATIVE; DNA TOPOISOMERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG DNA INTERACTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL CYCLE; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MOLECULAR STRUCTURE; PHENANTHROLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 79955600668     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.065     Document Type: Article

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