Novel amidino-substituted thienyl- and furylvinylbenzimidazole: Derivatives and their photochemical conversion into corresponding diazacyclopenta[c] fluorenes. Synthesis, interactions with DNA and RNA, and antitumor evaluation

Journal of Medicinal Chemistry

Volumn 51, Issue 16, 2008, Pages 4899-4910

  Hranjec, Marijana ^a   Piantanida, Ivo ^b   Kralj, Marijeta ^b   Šuman, Lidija ^b   Pavelić, Krešimir ^b   Karminski Zamola, Grace ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

(1H IMIDAZOL 2YL) 3 THIA 6,10B DIAZACYCLOPENTA[C]FLUORENE; 2 (2 FURAN 2 YLVINYL) 3H BENZIMIDAZOLE 5 CARBOXAMIDINE; 2 (2 FURAN 2 YLVINYL)N ISOPROPYL 3H BENZIMIDAZOLE 5 (6) CARBOXAMIDINE; 2 (2 THIOPHEN 2 YLVINYL) 3H BENZIMIDAZOLE 5 (6)CARBOXAMIDINE; 6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 (2 THIOPHEN 2 YLVINYL) 3H BENZIMIDAZOLE 5 (6)CARBOXAMIDINE; 6 (4,5 DIHYDRO 1H IMIDAZOL 2YL) 2 (2 FURAN 2 YLVINYL)N ISOPROPYL 3H BENZIMIDAZOLE 5 (6) CARBOXAMIDINE; CYCLOHEXYL 2 (2 FURAN 2 YLVINYL)N ISOPROPYL 3H BENZIMIDAZOLE 5 (6) CARBOXAMIDINE; CYCLOHEXYL 2 (2 THIOPHEN 2 YLVINYL) 3H BENZIMIDAZOLE 5 (6)CARBOXAMIDINE; CYCLOHEXYL 3 THIA 6,10B DIAZACYCLOPENTA[C]FLUORENE 8(9)CARBOXAMIDINE; DNA; DNA TOPOISOMERASE; FURYLVINYLBENZIMIDAZOLE; IMIDAZOLE DERIVATIVE; ISOPROPYL 2 (2 THIOPHEN 2 YLVINYL) 3H BENZIMIDAZOLE 5 (6)CARBOXAMIDINE; MORPHOLIN 4 YL 2 (2 THIOPHEN 2 YLVINYL) 3H BENZIMIDAZOLE 5 (6)CARBOXAMIDINE; N ISOPROPYL 3 THIA 6,10B DIAZACYCLOPENTA[C]FLUORENE 8(9)CARBOXAMIDINE; N MORPHOLIN 4 YL 3 THIA 6,10B DIAZACYCLOPENTA[C]FLUORENE 8(9)CARBOXAMIDINE; RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; COMPARATIVE STUDY; CYCLIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; PHOTOCHEMISTRY; TUMOR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE I; FLUORENES; HUMANS; NUCLEIC ACID DENATURATION; PHOTOCHEMISTRY; RNA; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 50249175013     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8000423     Document Type: Article

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