Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2547-2558

  Şerbetçi, Tuba ^a   Genès, Constance ^a   Depauw, Sabine ^b,c   Prado, Soizic ^a   Porée, François Hugues ^a   Hildebrand, Marie Paule ^b,c   David Cordonnier, Marie Hélène ^b,c   Michel, Sylvie ^a   Tillequin, François ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^c Institut de Recherche sur le Cancer de Lille   (France)

Author keywords

Benzo c 1,7 phenanthroline; Benzo c 1,8 phenanthroline; Cytotoxicity; DNA interaction

Indexed keywords

2 [[2' (DIETHYLAMINO)ETHYL]AMINO] 8,9 DIMETHOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[2' (DIETHYLAMINO)ETHYL]AMINO] 8,9 METHYLENEDIOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[2' (DIMETHYLAMINO)ETHYL]AMINO] 8,9 DIMETHOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[2' (DIMETHYLAMINO)ETHYL]AMINO] 8,9 METHYLENEDIOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[3' (DIETHYLAMINO)PROPYL]AMINO] 8,9 DIMETHOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[3' (DIETHYLAMINO)PROPYL]AMINO] 8,9 METHYLENEDIOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[3' (DIMETHYLAMINO)PROPYL]AMINO] 8,9 DIMETHOXYBENZO[C][1,7]PHENANTHROLINE; 2 [[3' (DIMETHYLAMINO)PROPYL]AMINO] 8,9 METHYLENEDIOXYBENZO[C][1,7]PHENANTHROLINE; ANTINEOPLASTIC AGENT; PHENANTHROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; NONHUMAN;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID DENATURATION; PHENANTHROLINES; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

EID: 77950861393     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.043     Document Type: Article

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