Oat Beta-Glucan: Its Role in Health Promotion and Prevention of Diseases

Comprehensive Reviews in Food Science and Food Safety

Volumn 11, Issue 4, 2012, Pages 355-365

  Daou, Cheickna ^a   Zhang, Hui ^b,c  

^a State Key Laboratory of Food Science and Technology   (China)

^b JIANGNAN UNIVERSITY   (China)

^c and Technologies of Bamako   (Mali)

Author keywords

[No Author keywords available]

Indexed keywords

BETA-GLUCANS; BODY WEIGHT; CARDIO-VASCULAR DISEASE; EXTRACTION METHOD; GASTROINTESTINAL TRACT; HEALTH BENEFITS; HEALTH PROMOTION; HIGH-DENSITY LIPOPROTEINS; IMMUNE FUNCTION; LIPID PROFILE; LOW DENSITY LIPOPROTEINS; MONOCYTES/MACROPHAGES; NK CELLS; PHYSICOCHEMICAL PROPERTY; T CELLS;

BLOOD; CHOLESTEROL; DISEASES; HEALTH;

DISEASE CONTROL;

EID: 84862256964     PISSN: None     EISSN: 15414337     Source Type: Journal    
DOI: 10.1111/j.1541-4337.2012.00189.x     Document Type: Article

References (115)

1. Anderson JW, Deakins DA, Floore TL, Smith BM, Whitis SE. 1990a. Dietary fiber and coronary heart disease. Crit Rev Food Sci Nutr 29:95-147.
2. Anderson JW, Gilinsky NH, Deakins DA, Smith SF, O'Neal DS, Dillon DW, Oeltgen PR. 1991. Lipid responses of hypercholesterolemic men to oat-bran and wheat-bran intake. Am J Clin Nutr 54:678-83.
3. Anderson JW, Spencer DB, Hamilton CC, Smith SF, Tietyen J, Bryant CA, Oeltgen PR. 1990b. Oat-bran cereal lowers serum total and LDL cholesterol in hypercholesterolemic men. Am J Clin Nutr 52:495-9.
4. Anderson JW, Story L, Sieling B, Chen WJL, Petro MS, Story J. 1984. Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. Am J Clin Nutr 40:1146-55.
5. Anorldi A. 2004. Functional foods, cardiovascular disease and diabetes. Cambridge, UK: Woodhead Publishing Ltd and Boca Raton, Fla.: CRC Press 475 p.
6. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GM, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanjer N. 1997. A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group. N Engl J Med 336:1117-24.
7. Asif A, Faqir MA, Tahr Z, Haq Nawaz ZA. 2010. Extraction and characterization of β-D-glucan from oat for industrial utilization. Int J Biol Macromol 46:304-9.
8. Bach Knudsen KE, Hansen I, Borg JB, Ostergard K.1990. Physiological implications of wheat and oat dietary fibre. In: Furda I, Brine CJ, editors. New developments in dietary fiber. New York : Plenum Press. p 135-50.
9. Bae IY, Kim SM, Lee S, Lee HG. 2010. Effect of enzymatic hydrolysis on cholesterol-lowering activity of oat beta-glucan. N. Biotechnol 27(1):85-8.
10. Battilana P, Ornstein K, Minehira K, Schwarz JM, Acheson K, Schneiter P, Burri J, Jeâquier E, Tappy L. 2001. Mechanism of action of beta-glucan in postprandial glucose metabolism in healthy men. Eur J Clin Nutr 55:327-33.
11. Beer MU, Arrigoni E, Amadoa R. 1996. Extraction of oat gum from oat bran: effects of process on yield, molecular weight distribution, viscosity, and (1, 3) (1, 4)-beta-D-glucan content of the gum. Cereal Chem 73(1):58-62.
12. Begin F, Vachon C, Jones JD, Wood PJ, Savoie L. 1989. Effect of dietary fibres on glycemia and insulinemia and on gastrointestinal function in rats. Can J Physiol Pharmacol 67:1265-71.
13. Behall KM, Scholfield DJ, Hallfrisch JG. 2006. Barley b-glucan reduces plasma glucose and insulin responses compared with resistant starch in men. Nutr Res 26:644-50.
14. Bhatty RS. 1993. Extraction and enrichment of (1-3) (1-4)-beta-D-glucan from barley and oat brans. Cereal Chem 70:73-77.
15. Biörklund M, van Rees A, Mensink RP, Önning G. 2005. Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with β-glucans from oats or barley: a randomised dose-controlled trial. Eur J Clin Nutr 59:1272-81.
16. Braaten JT, Wood PJ, Scott FW, Wolynetz MS, Lowe MK, Bradley-White P, Collins MW. 1994. Oat β-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects. Eur J Clin Nutr 48:465-74.
17. Casterline JL Jr, Oles CJ, Ku Y. 1997. In vitro fermentation of various food fiber fractions. J Agric Food Chem45:2463-7.
18. Charles SB. 2005. Dietary fiber, glycemic response, and diabetes. Mol Nutr Food Res 49:560-70.
19. Chen J, Raymond K. 2006. Nuclear receptors, bile-acid detoxification, and cholestasis. Lancet 367:454-6.
20. Chen JH, Huang X-F. 2009. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol 3:154-8
21. Chen SN, Nan FH, Chen S, Wu JF, Lu CL, Soni MG. 2011. Safety assessment of mushroom β-glucan: subchronic toxicity in rodents and mutagenicity studies. Food Chem Toxicol 49(11):2890-8.
22. Cheung NKV, Modak S, Vickers A, Knuckles B. 2002. Orally administrered β-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother 51 (10):557-64.
23. Cho SS. 2001. Handbook of dietary fiber. New York : Marcel Dekker, Inc. 868 p.
24. Cui W, Wood PJ. 2000. Relationships between structural features, molecular weight, and rheological properties of cereal b-D-glucans. In: Nishinari K, editor. Hydrocolloids (vol.1). Physical chemistry and industrial applications of gels, polysaccharides and proteins. Nottingham, UK : Elsevier Science Ltd. p 159-68.
25. Davidson MH, Dugan LD, Burns JH, Bova J, Story K, Drennan KB. 1991. The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study. JAMA 265(14):1833-9.
26. Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A, Mayer EP. 2004a. Effects of moderate exercise and oat β-glucan on innate immune function and susceptibility to respiratory infection. Am J Physiol Regul Integr Comp Physiol 286:R366-72.
27. Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A, Mayer EP. 2004b. Effects of oat β-glucan on innate immunity and infection after exercise stress. Med Sci Sports Exerc 36:1321-7.
28. Demir G., Klein HO, Mandel-Molinas N, Tuzuner N. 2007. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol 7(1):113-6.
29. di Luzio NR, Williams DL, Mcnamee RB, Edwards BF, Kitahama A. 1979. Comparative tumor inhibitory and anti-bacterial activity of soluble and particulate glucana. Int J Cancer 24:773-9.
30. Dikeman CL, Fahey GC. 2006. Viscosity as related to dietary fiber: a review. Crit Rev Food Sci Nutr 46:649-63.
31. Dikeman CL, Murphy MR, Fahey GC Jr. 2006. Dietary fibers affect viscosity of solutions and simulated human gastric and small intestinal digesta. J Nutr 136(4):913-9.
32. Dong JL, Cai FL, Shen RL, Liu Y.2011. 2011. Hypoglycemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice. Food Chem 129:1066-71.
33. Drozdowski LA, Reimer RA, Temelli F, Bell RC, Vasanthan T, Thomson ABR. 2010. β-Glucan extracts inhibit the in vitro intestinal uptake of long-chain fatty acids and cholesterol and down-regulate genes involved in lipogenesis and lipid transport in rats. J Nutr Biochem 21(8):695-701.
34. Ellegard L, Andersson H. 2007. Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. Eur J Clin Nutr 61:938-45.
35. Estrada A, Yun CH, van Kessel A, Li B, Hauta S, Laarveld B. 1997. Immunomodulatory activities of β-glucan in vitro and in vivo. Microbiol Immunol 41(12):991-8.
36. Fucher RG, Muller SS. 1993. Structure of oat bran and distribution of dietary components. In: Wood P, editor. Oat bran. St. Paul, Minnesota : American Association of Cereal Chemists. p 1-24.
37. Gibson GG, Roberfroid MB. 1995. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401-12.
38. Granfeldt Y, Hagander B, Bjoerck I. 1995. Metabolic responses to starch in oat and wheat products. On the importance of food structure, incomplete gelatinisation, or presence of viscous dietary fiber. Eur J Clin Nutr 49:189-99.
39. Hetland G, Ohno N, Aaberge IS, Løvik M. 2000. Protective effect of β-glucan against systemic Streptococcus pneumoniae infection in mice. FEMS Immunol Med Microbiol 27:111-6.
40. Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. 2003. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res63(24): 9023-31.
41. Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. 2004. Mechanism by which orally administered β-(1, 3)-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol 173(2):797-806.
42. Hooda S, Matte JJ, Vasanthan T, Zijlstra RT. 2010. Dietary purified oat β-glucan reduces peak glucose absorption and portalinsulin release in portal-vein catheterized grower pigs. Livest Sci 134(1-3):15-7.
43. Howarth NC, Saltzman E, Roberts SB. 2001. Dietary fiber and weight regulation. Nutr Rev 59(5):129-39.
44. Hsing-Hsien C, Ming-Hoang L. 2000. Fermentation of resistance starch produces propionate reducing serum and hepatic cholesterol in rats. J Nutr 130:1991-5.
45. Illman RJ, Topping DL. 1985. Effects of dietary oat bran on faecal steroid excretion, plasma volatile fatty acids, and lipid synthesis in rats. Nutr Res 5:839-46.
46. Jeon H, Blacklow SC. 2005. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 74:535-62.
47. Johansen HN, Bach Knudsen KE, Wood PJ, Fulcher RG. 1997. Physicochemical properties and the degradation of oat bran polysaccharides in the gut of pigs. J Sci Food Agric 73:81-92.
48. Johansson L, Virkki L, Anttila H, Esselström H, Tuomainen P, Sontag-Strohm T. 2006. Hydrolysis of β-glucan. Food Chem 97:71-9.
49. Johansson L, Virkki L, Mannus S, Letho M, Ekholm P, Varo P. 2000. Structural characterization of water soluble β-glucan of oat bran. Carbohydr Polym 42:143-8.
50. Juvonen KR, Salmenkallio-Marttila M, Lyly M, Liukkonen K-H, Lähteenmäki L, Laaksonen DE, Uusitupa MI, Herzig KH, Poutanen KS, Karhunen LJ. 2011. Semisolid meal enriched in oat bran decreases plasma glucose and insulin levels, but does not change gastrointestinal peptide responses or short-term appetite in healthy subjects. Nutr Metab Cardiovasc Dis 21(9):748-56.
51. Kabir M, Oppert J-M, Vidal H, Bruzzo F, Fiquet C, Wuè Rsch P, Slama G, Rizkalla SW. 2002. Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2-diabetic men. Metabolism 51(7):819-26.
52. Kaiser AB, Kernodle D. 2002. Synergism between poly-(1-6)-β-D-glucopyranose glucana and cefazolin in prophylaxis of staphylococcal wound infection in guinea pig model. Antimicrobiol Agents Chemother 42:2449-51.
53. Keenan JM, Pins JJ, Frazel C, Moran A, Turnquist L. 2002. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J Fam Pract 51:369-74.
54. Kerckhoffs AJM, Hornstra G, Mensink RP. 2003. Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies. Am J Clin Nutr 78:221-7.
55. Kestin M, Moss R, Clifton PM, Nestel PJ. 1990. Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men. Am J Clin Nutr 52:661-6.
56. Koplan JP, Liverman CT, Kraak VI. 2005. Preventing childhood obesity: health in the balance: executive summary. J Am Diet Assoc 105:131-8.
57. Law MR, Wald NJ, Wu T, Hackshaw A, Bailey A. 1994. Systematic underestimation of association between serum cholesterol concentration and ischaemic heart disease in observational studies: data from the BUPA study. BMJ 308:363-6.
58. Lazaridou A, Biliaderis CG. 2007. Molecular aspects of cereal β-glucan functionality: physical properties, technological applications, and physiological effects. J Cereal Sci 46(2):101-18.
59. Li W, Cui SW, Wang Q, Yada RY. 2011. Studies of aggregation behaviors of cereal β-glucans in dilute aqueous solutions by light scattering: part I. Structure effects. Food Hydrocolloid 25(2):189-95.
60. Lia A, Hallmans G, Sandberg A-S, Sundberg B, Aman P, Andersson H. 1995. Oat β-glucan increases bile acid excretion and a fibre-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am J Clin Nutr 62:1245-51.
61. Lia A, Sundberg B, Aman P, Sandberg A-S, Hallmans G, Andersson H. 1996. Substrates available for colonic fermentation from oat, barley, and wheat diets. A study in ileostomy subjects. Br J Nutr 76:797-808.
62. Liang J, Melican D, Cafro L, Palace G, Fisette L, Armstrong R, Patchen ML. 1998. Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats tested with PGG-glucan is associated with increased leukocyte counts and increased neutophil oxidative burst activity. Int J Immunopharmacol 20:595-614.
63. Liu J, Gunn L, Hansen R, Yan J. 2009. Combined yeast-derived β-glucan with ant-tumor monoclonal antibody for cancer immunotherapy. Exp Mol Pathol 86(3):208-14.
64. Lund EK, Gee JM, Brown JC, Wood PJ, Johnson IT. 1989. Effect of oat gum on the physical properties of the gastrointestinal contents and on the uptake of D-galactose and cholesterol by rat small intestine in vitro. Br J Nutr 62:91-101.
65. Maki KC, Schinnick F, Sceley MA, Veith PE, Quinn LC, Hallissey PJ, Temer A, Davidson MH. 2003. Food products containing free tall-oil based phytosterol and oat β-glucan lower serum total and LDL-cholesterol in hypercholesterolemic adults. J Nutri 133(3):808-13.
66. Mälkki Y, Virtanen E. 2001. Gastrointestinal effects of oat bran and oat gum. A review Lebensm.-Wiss Technol 34:337-47.
67. Mårtenssona O, Duenä-Chascob M, Irastorzab A, Holsta O, Rudlingc M, Norind E, Midtvedte T, Östef R. 2002. Effects of fermented, ropy, non-dairy, oat-based products on serum lipids and the faecal excretion of cholesterol and short chain fatty acids in germfree and conventional rats. Nutr Res 22(12):1461-73.
68. Mertens IL, Van Gall LF. 2000. Overweight, obesity, and blood pressure: the effects of modest weight loss. Obes Res 8:270-8.
69. Morgan K. 2000. Cereal β-glucans. In: Handbook of hydrocolloids. Phillips GO, Williams PA, editors. Cambridge : Woodhead Publishing Limited. p 287-307.
70. Murphy EA, Davids JM, Brown AS, Carmichael MD, Carson JA, van Rooijen N, Ghaffar A, Mayer EP. 2008. Benefits of oat β-glucan on respiratory infection following exercise stress: role of lungmacrophages. Am J Physiol Regul Integr Comp Physiol294(5):RI 1593-9.
71. Murphy EA, Davis JM, Brown AS, Carmichael MD, Mayer EP, Ghaffar A. 2004. Effects of moderate exercise and oat β -glucan on lung tumor metastases and macrophage antitumor cytotoxicity. J Appl Physiol 97:955-9.
72. Murphy EA, Davis JM, Carmichael MD, Gangemi JD, Ghaffar A, Mayer EP. 2008. Exercise stress increases susceptibility to influenza infection. Brain Behav Immun 22:1152-5.
73. Murphy EA, Davis JM, Carmichael MD, Mayer EP, Ghaffar A. 2009. Benefits of oat β-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. Am J Physiol Regul Integr Comp Physiol 297:R1188-94.
74. Nieman DC, Henson DA, McMahon M, Wrieden JL, Davis JM, Murphy EA, Gross SJ, McAnulty LS, Dumke CL. 2008. β-Glucan, immune function, and upper respiratory tract infections in athletes. Med Sci Sports Exerc 40:1463-71.
75. Pins JJ, Geleva D, Keenan JM, Frazel C, O'Connor PJ, Cherney LM. 2002. Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control? J Fam Practice 51(4):353-9.
76. Queenan KM, Stewart ML, Smith KN, Thomas W, Fulcher RG, Slavin JL. 2007. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutr J 6:Doi:
77. Regand A, Chowdhury Z, Tosh SM, Wolever TMS, Wood P. 2011. The molecular weight solubility and viscosity of oat beta-glucan affect human glycemic response by modifying starch digestibility. Food Chem 129:297-304.
78. Reyna-Villasmil N, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili Z H, Hernández-Hernández R, Valasco M, Arraiz N. 2007. Oat-derived [beta]-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. Am J Ther 14(2):203-12.
79. Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, Ensley HE, Brown G.D, Gordon S, Williams DL. 2005. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther 314(3):1079-86.
80. Ripsin CM, Keenan JM, Jacobs DR, Elmer PJ, Welch RR, van Horn L, Liu K, Turnbull WH, Thye FW, Kestin M, Hegsted M, Davidson DM, Davidson MH, Dugan LD, Demark-Wahnefried W, Beling S. 1992. Oat products and lipid lowering. JAMA 267(24):3317-25.
81. Rodriguez I, Chamorro R, Novoa B, Figueras A. 2009. β-Glucan administration enhances disease resistance and some innate immune responses in zebrafish (Danio rerio). Fish Shellfish Immun 27:369-73.
82. Saltzman E, Das SK, Lichtenstein AH, Dallal GE, Corrales A, Schaefer EJ, Greenberg A, Roberts SB. 2001. An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J Nutr 131:1465-70.
83. Satchithanandam S, Vargofcak-Apker M, Calvert R J, Leeds AR, Cassidy MM. 1990. Alteration of gastrointestinal mucin by fiber feeding in rats. J Nutr 120:1179-84.
84. Sissener EC, Engstad RE, Olsen JO, Østerud B. 2002. The effect of soluble h-1, 3-glucan and lipopolysaccharide on cytokine production and coagulation activation in whole blood. Int Immunopharmacol 2:1585-97.
85. Slavin JL. 2005. Dietary fiber and body weight. Nutrition 21:411-418.
86. Streppel MT, Arends LR, van 't Veer P, Grobbee DE, Geleijnse JM. 2005. Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 165:150-6.
87. Tapola N, Harvonen H, Niskamen L, Mikola M, Sarkkinen 2005. Glycemic responses of oat bran products in type 2-diabetic patients. Nutr Metab Cardiovasc Dis 15:255-61.
88. Tappy L, Guè Golz E, Wuè Rsch P. 1996. Effects of breakfast cereals containing various amounts of β-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care 19(8):831-4.
89. Theuwissen E, Mensink RP. 2008. Water-soluble dietary fibers and cardiovascular disease-a review. Physiology & Behavior 94(2):285-92.
90. Tiwari U, Cummins E. 2011. Meta-analysis of the effect of beta-glucan intake on blood cholesterol and glucose levels. Nutrition 27(10):1008-16.
91. Tohamy AA, El-Gohr AA, El-Nahas SM, Noshy MM. 2003. β-Glucan inhibits the genotoxicity of cyclophosphamide, adramycin, and cisplatin. Mutat Res 541:45-53.
92. U.S Federal Food and Drug Administration. 1997. Food labeling: health claims; oats a coronary heart disease. Final rule. Fed Regist 62(15):3583-601.
93. Ulmius M, Johansson-Persson A, Immerstrand Nordén T, Bergenståhl B, Önning G. 2011. Gastrointestinal release of β-glucan and pectin using an in vitro method. Cereal Chem Doi:
94. Ulmius M, Adapa S, Önning G, Nilsson L. 2012. Gastrointestinal conditions influence the solution behaviour of cereal β-glucans in vitro. Food Chem 130(3):536-40.
95. van der Sluijs AMC, Behall KM, Douglass L, Prather E, Scholfield DJ, Hallfrisch J.1999. Effect of cooking on the beneficial soluble beta-glucans in Oatrim. Cereal Food World 44:194-8.
96. Vetvicka V, Terayama K, Mandeville R, Brousseau P, Kournikakis B, Ostroff G. 2002. Pilot study: orally-administered yeast β1, 3-glucan prophylactically protects against anthrax infection and cancer in mice. JANA 5(2):5-9.
97. Volman JJ, Mensink RP, Ramakers JD, de Winther MP, Carlsen H, Blomhoff R, Buurman WA, Plat J. 2010b. Dietary (1→3), (1→4) β-D-glucan from oat activate nuclear factor-kappa Bin intestinal leukocytes and enterocytes from mice. Nutr Res 30(1):40-8.
98. Wang Q, Wood PJ, Cui W. 2002. Microwave-assisted dissolution of β-glucan in water-implications for the characterization of this polymer. Carbohydr Pol 47(1):35-8.
99. Watkins LO. 2004. Epidemiology and burden of cardiovascular disease. Clin Cardiol 27:III2-6.
100. Welsh RW. 1995. Oat crop: Production and utilization. London : Chapman and Hall. 584 p.
101. Westerlund E, Andersson R, Åman P. 1993. Isolation and chemical characterization of water-soluble mixed-linked β-glucans and arabinoxylans in oat milling fractions. Carbohydr Pol 20:115-23.
102. Willet W, Manson J, Liu S. 2002. Glycemic index, glycemic load, and risk of type 2-diabetes. Am J Clin Nutr 76:274S-80S.
103. Williams DL, Mueller A, Browder W. 1996. Glucan-based macrophage stimulators. A review of their anti-infective potential. Clin Immunother 5:392-9.
104. Wolever TM, Fernandes J, Rao AV. 1996 Serum acetate: propionate ratio is related to serum cholesterol in men but not women. J Nutr 126:2790-7.
105. Wood PJ, Beer MU, Butler G. 2000. Evaluation of the role of concentration and molecular weight of oat β-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load. Br J Nutr 84:19-23.
106. Wood PJ, Braaten JT, Scott FW, Riedel KD, Wolynetz MS, Collins MW. 1994. Effect of dose and modification of viscous properties of oat gum on plasma glucose and insulin following an oral glucose load. Br J Nutr 72:731-43.
107. Wood PJ, Siddiqui IJ, Paton D. 1978. Extracting of high-viscosity gums from oats. Cereal Chem 55:1038-49.
108. Wood PJ, Weisz J, Blackwell BA. 1991. Molecular characterization of cereal β-glucans. Structural analysis of oat β-glucan and rapid structural evaluation of β-glucans from different sources by high-performance liquid chromatography of oligosaccharides released by lichenase. Cereal Chem 68:31-9.
109. Wood PJ. 2007. Cereal β-glucans in diet and health. J Cereal Sci 46:230-8.
110. Wright RS, Anderson JW, Bridges SR. 1990. Propionate inhibits hepatic lipid synthesis. Proc Soc Exp Biol Med 190:26-9.
111. Xiaoa ZG, Trincadob CA, Murtaugh MP.2004 β-Glucan enhancement of T cell IFN response in swine. Vet Immunol Immunopathol 102:315-20.
112. Yang JL, Jang JH, Radhakrishnan V, Kim YH, Song YS. 2008. β-Glucan suppresses LPS-stimulated NO production through the down-regulation of iNOS expression and NFkB transactivation in RAW 264.7 macrophages. Food Sci Biotechnol 17:106-13.
113. Yun C H, Estrada A, van Kessel A, Park BC, Laarveld B. 2003. Beta-glucan extracted from oat enhances disease resistance against bacterial and parasitic infections. FEMS Immunol Med Microbiol 35(1):67-75.
114. Yun CH, Estrada A, van Kessel A, Gajadhar A, Redmond MJ, Laarveld B 1997. β-(l→3, l→4) Oat glucan enhances resistance to Eimeria vermiformis infection in immunosuppressed mice. Int J Parasitol 27:329-31.
115. Yun CH, Estrada A, van Kessel A, Park BC, Laarveld B. 2003. β-Glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol Med Microbiol 35:67-75.