Conantokins derived from the Asprella clade impart con Rl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits

Biochemistry

Volumn 51, Issue 23, 2012, Pages 4685-4692

  Gowd, Konkallu Hanumae ^a,c   Han, Tiffany S ^a   Twede, Vernon ^a   Gajewiak, Joanna ^a   Smith, Misty D ^a   Watkins, Maren ^b   Platt, Randall J ^a   Toledo, Gabriela ^a   White, H Steve ^a   Olivera, Baldomero M ^a   Bulaj, Grzegorz ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO GROUP; ANTIEPILEPTIC DRUGS; CHEMICAL SYNTHESIS; CLINICAL APPLICATION; CONE SNAILS; D-ASPARTATE; DIVALENT METAL ION; HELICAL CONFORMATION; HIGH POTENCY; ION CHANNEL; MOLECULAR PHYLOGENY; NATURAL PRODUCTS; NMDA RECEPTOR; PEPTIDIC LIGANDS; POTENTIAL TARGETS; RECEPTOR ANTAGONISTS; SEQUENCE SIMILARITY; STRUCTURE-ACTIVITY STUDIES;

BIOCHEMISTRY; CHEMISTRY;

BIOLOGY;

CONANTOKIN G; CONANTOKIN RI B; MARINE TOXIN; METAL ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CONUS ROLANI; CONUS SNAIL; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; EPILEPSY; HETEROLOGOUS EXPRESSION; MOLECULAR PHYLOGENY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEIZURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTICONVULSANTS; CLONING, MOLECULAR; CONOTOXINS; CONUS SNAIL; DNA; EPILEPSY; GENE EXPRESSION REGULATION; GENOME; MICE; PEPTIDES; PROTEIN CONFORMATION; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84862202566     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300055n     Document Type: Article

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