The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B

Neuropharmacology

Volumn 57, Issue 2, 2009, Pages 127-136

  Sheng, Zhenyu ^a   Liang, Zhong ^a   Geiger, James H ^b   Prorok, Mary ^a   Castellino, Francis J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Conantokins; Electrophysiology; Ion channels; NMDAR mutagenesis; NMDAR subtypes

Indexed keywords

AMINO ACID; CONANTOKIN G; ION CHANNEL; LYSINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MUTAGENESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONOTOXINS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HUMANS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-METHYLASPARTATE; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POINT MUTATION; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS;

EID: 67650125196     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.04.014     Document Type: Article

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