Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity

Molecular Brain

Volumn 5, Issue 1, 2012, Pages

  Wang, Min ^a   Li, Shupeng ^a   Zhang, Hongyu ^a   Pei, Lin ^a   Zou, Shengwei ^a   Lee, Frank J S ^a   Wang, Yu Tian ^b   Liu, Fang ^a,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE MODEL; EXCITOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; CELL DEATH; CELLS, CULTURED; ENDOCYTOSIS; EXTRACELLULAR SPACE; GLUCOSE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; NEURONS; NEUROTOXINS; OXYGEN; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, AMPA; TRANSFECTION;

EID: 84862171242     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-5-13     Document Type: Article

References (88)

1. A synaptic model of memory: long-term potentiation in the hippocampus. Bliss TV, Collingridge GL, Nature 1993 361 31 39 10.1038/361031a0 8421494 (Pubitemid 23020772)
2. Glutamate neurotoxicity and diseases of the nervous system. Choi DW, Neuron 1988 1 623 634 10.1016/0896-6273(88)90162-6 2908446
3. Cloned glutamate receptors. Hollmann M, Heinemann S, Annu Rev Neurosci 1994 17 31 108 10.1146/annurev.ne.17.030194.000335 8210177 (Pubitemid 24117025)
4. A family of AMPA-selective glutamate receptors. Keinanen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH, Science 1990 249 556 560 10.1126/science.2166337 2166337
5. Molecular cloning and functional expression of glutamate receptor subunit genes. Boulter J, Hollmann M, OShea-Greenfield A, Hartley M, Deneris E, Maron C, Heinemann S, Science 1990 249 1033 1037 10.1126/science.2168579 2168579
6. Calcium: still center-stage in hypoxic-ischemic neuronal death. Choi DW, Trends Neurosci 1995 18 58 60 10.1016/0166-2236(95)93870-4 7537408
7. Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Simon RP, Swan JH, Griffiths T, Meldrum BS, Science 1984 226 850 852 10.1126/science.6093256 6093256 (Pubitemid 15200682)
8. Global ischemia-induced modifications in the expression of AMPA receptors and inflammation in rat brain. Dos-Anjos S, Martinez-Villayandre B, Montori S, Regueiro-Purrinos MM, Gonzalo-Orden JM, Fernandez-Lopez A, Brain Res 2009 1287 20 27 19563786
9. Extended therapeutic time window after focal cerebral ischemia by non-competitive inhibition of AMPA receptors. Elger B, Gieseler M, Schmuecker O, Schumann I, Seltz A, Huth A, Brain Res 2006 1085 189 194 10.1016/j.brainres. 2006.02.080 16580649 (Pubitemid 43728194)
10. Pharmacology of AMPA antagonists and their role in neuroprotection. Gill R, Lodge D, Int Rev Neurobiol 1997 40 197 232 8989622
11. The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. Gressens P, Spedding M, Gigler G, Kertesz S, Villa P, Medja F, Williamson T, Kapus G, Levay G, Szenasi G, et al. Eur J Pharmacol 2005 519 58 67 10.1016/j.ejphar.2005.06.031 16112106 (Pubitemid 43181165)
12. Reduction of cerebral infarct size by non-competitive AMPA antagonists in rats subjected to permanent and transient focal ischemia. Matucz E, Moricz K, Gigler G, Simo A, Barkoczy J, Levay G, Harsing LG, Szenasi G, Brain Res 2004 1019 210 216 10.1016/j.brainres.2004.05.098 15306255 (Pubitemid 39078626)
13. White matter axon vulnerability to AMPA/kainate receptor-mediated ischemic injury is developmentally regulated. McCarran WJ, Goldberg MP, J Neurosci 2007 27 4220 4229 10.1523/JNEUROSCI.5542-06.2007 17429000 (Pubitemid 46597173)
14. Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons. Oguro K, Oguro N, Kojima T, Grooms SY, Calderone A, Zheng X, Bennett MV, Zukin RS, J Neurosci 1999 19 9218 9227 10531425 (Pubitemid 30228074)
15. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats. Pellegrini-Giampietro DE, Zukin RS, Bennett MV, Cho S, Pulsinelli WA, Proc Natl Acad Sci USA 1992 89 10499 10503 10.1073/pnas.89.21.10499 1438239
16. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Peng PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu D, Lau L, Liu S, Liu F, Lu Y, Neuron 2006 49 719 733 10.1016/j.neuron.2006.01.025 16504947 (Pubitemid 43290131)
17. Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Pulsinelli WA, Levy DE, Duffy TE, Ann Neurol 1982 11 499 502 10.1002/ana.410110510 7103426
18. Selective vulnerability of the hippocampus in brain ischemia. Schmidt-Kastner R, Freund TF, Neuroscience 1991 40 599 636 10.1016/0306-4522(91) 90001-5 1676492
19. Ca2+Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration. Weiss JH, Sensi SL, Trends Neurosci 2000 23 365 371 10.1016/S0166-2236(00)01610-6 10906800 (Pubitemid 30628813)
20. Blockade of Ca2+permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons. Yin HZ, Sensi SL, Ogoshi F, Weiss JH, J Neurosci 2002 22 1273 1279 11850455 (Pubitemid 34163729)
21. The AMPAR subunit GluR2: still front and center-stage. Tanaka H, Grooms SY, Bennett MV, Zukin RS, Brain Res 2000 886 190 207 10.1016/S0006-8993(00) 02951-6 11119696
22. Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Geiger JR, Melcher T, Koh DS, Sakmann B, Seeburg PH, Jonas P, Monyer H, Neuron 1995 15 193 204 10.1016/0896-6273(95)90076-4 7619522
23. RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum. Greger IH, Khatri L, Ziff EB, Neuron 2002 34 759 772 10.1016/S0896-6273(02)00693-1 12062022 (Pubitemid 34628738)
24. Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Jonas P, Racca C, Sakmann B, Seeburg PH, Monyer H, Neuron 1994 12 1281 1289 10.1016/0896-6273(94)90444-8 8011338
25. Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA, Neuron 2009 62 254 268 10.1016/j.neuron.2009.02.027 19409270
26. Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons. Wenthold RJ, Petralia RS, Blahos J, Niedzielski AS, J Neurosci 1996 16 1982 1989 8604042 (Pubitemid 26144011)
27. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Dong H, OBrien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL, Nature 1997 386 279 284 10.1038/386279a0 9069286 (Pubitemid 27142513)
28. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. Dong H, Zhang P, Song I, Petralia RS, Liao D, Huganir RL, J Neurosci 1999 19 6930 6941 10436050 (Pubitemid 29380121)
29. Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Lee SH, Liu L, Wang YT, Sheng M, Neuron 2002 36 661 674 10.1016/S0896-6273(02)01024-3 12441055 (Pubitemid 35346759)
30. NSF binding to GluR2 regulates synaptic transmission. Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, Tagaya M, Collingridge GL, Nakanishi S, Henley JM, Neuron 1998 21 87 97 10.1016/S0896-6273(00)80517-6 9697854 (Pubitemid 28355694)
31. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Osten P, Srivastava S, Inman GJ, Vilim FS, Khatri L, Lee LM, States BA, Einheber S, Milner TA, Hanson PI, Ziff EB, Neuron 1998 21 99 110 10.1016/S0896-6273(00) 80518-8 9697855 (Pubitemid 28355695)
32. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, et al. Neuron 1998 21 581 591 10.1016/S0896-6273(00)80568-1 9768844 (Pubitemid 28475509)
33. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. Wyszynski M, Valtschanoff JG, Naisbitt S, Dunah AW, Kim E, Standaert DG, Weinberg R, Sheng M, J Neurosci 1999 19 6528 6537 10414981 (Pubitemid 29347452)
34. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Xia J, Zhang X, Staudinger J, Huganir RL, Neuron 1999 22 179 187 10.1016/S0896-6273(00)80689-3 10027300 (Pubitemid 29070104)
35. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. OBrien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P, Neuron 1999 23 309 323 10.1016/S0896-6273(00)80782-5 10399937 (Pubitemid 29315726)
36. Extracellular interactions between GluR2 and N-cadherin in spine regulation. Saglietti L, Dequidt C, Kamieniarz K, Rousset MC, Valnegri P, Thoumine O, Beretta F, Fagni L, Choquet D, Sala C, et al. Neuron 2007 54 461 477 10.1016/j.neuron.2007.04.012 17481398 (Pubitemid 46659810)
37. Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading. Yamaji R, Chatani E, Harada N, Sugimoto K, Inui H, Nakano Y, Biochim Biophys Acta 2005 1726 261 271 10.1016/j.bbagen.2005.07.013 16125849 (Pubitemid 41668534)
38. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Chuang DM, Hough C, Senatorov VV, Annu Rev Pharmacol Toxicol 2005 45 269 290 10.1146/annurev.pharmtox.45.120403.095902 15822178 (Pubitemid 40261806)
39. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, et al. Nat Cell Biol 2005 7 665 674 10.1038/ncb1268 15951807 (Pubitemid 40975747)
40. Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neurons. Ishitani R, Chuang DM, Proc Natl Acad Sci USA 1996 93 9937 9941 10.1073/pnas.93.18.9937 8790435 (Pubitemid 26296713)
41. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis. Ishitani R, Tanaka M, Sunaga K, Katsube N, Chuang DM, Mol Pharmacol 1998 53 701 707 9547361 (Pubitemid 28196493)
42. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Sawa A, Khan AA, Hester LD, Snyder SH, Proc Natl Acad Sci USA 1997 94 11669 11674 10.1073/pnas.94.21.11669 9326668 (Pubitemid 27451056)
43. The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice. Iihara K, Joo DT, Henderson J, Sattler R, Taverna FA, Lourensen S, Orser BA, Roder JC, Tymianski M, J Neurosci 2001 21 2224 2239 11264298 (Pubitemid 32240521)
44. Excitotoxicity at both NMDA and non-NMDA glutamate receptors is antagonized by aurintricarboxylic acid: evidence for differing mechanisms of action. Zeevalk GD, Schoepp D, Nicklas WJ, J Neurochem 1995 64 1749 1758 7891104
45. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. Goldberg MP, Choi DW, J Neurosci 1993 13 3510 3524 8101871 (Pubitemid 23241187)
46. Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death. Ying HS, Weishaupt JH, Grabb M, Canzoniero LM, Sensi SL, Sheline CT, Monyer H, Choi DW, J Neurosci 1997 17 9536 9544 9391008 (Pubitemid 28006397)
47. Dynamin-dependent endocytosis of ionotropic glutamate receptors. Carroll RC, Beattie EC, Xia H, Luscher C, Altschuler Y, Nicoll RA, Malenka RC, von Zastrow M, Proc Natl Acad Sci USA 1999 96 14112 14117 10.1073/pnas.96.24.14112 10570207
48. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M, Nat Neurosci 2000 3 1282 1290 10.1038/81814 11100149
49. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT, Neuron 2000 25 649 662 10.1016/S0896- 6273(00)81067-3 10774732
50. Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors. Pei L, Lee FJ, Moszczynska A, Vukusic B, Liu F, J Neurosci 2004 24 1149 1158 10.1523/JNEUROSCI.3922-03.2004 14762133 (Pubitemid 38177022)
51. Preferential Zn2+ influx through Ca2+permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Sensi SL, Yin HZ, Carriedo SG, Rao SS, Weiss JH, Proc Natl Acad Sci USA 1999 96 2414 2419 10.1073/pnas.96.5.2414 10051656 (Pubitemid 29117929)
52. Modulation of mitochondrial function by endogenous Zn2+ pools. Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH, Proc Natl Acad Sci USA 2003 100 6157 6162 10.1073/pnas.1031598100 12724524 (Pubitemid 36576947)
53. Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH, J Neurosci 2009 29 1105 1114 10.1523/JNEUROSCI.4604-08.2009 19176819
54. Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. Jiang D, Sullivan PG, Sensi SL, Steward O, Weiss JH, J Biol Chem 2001 276 47524 47529 10.1074/jbc.M108834200 11595748
55. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+channels. Bossy-Wetzel E, Talantova MV, Lee WD, Scholzke MN, Harrop A, Mathews E, Gotz T, Han J, Ellisman MH, Perkins GA, Lipton SA, Neuron 2004 41 351 365 10.1016/S0896- 6273(04)00015-7 14766175 (Pubitemid 38221040)
56. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Kwak S, Weiss JH, Curr Opin Neurobiol 2006 16 281 287 10.1016/j.conb.2006.05.004 16698262 (Pubitemid 43949226)
57. Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites. Liu B, Liao M, Mielke JG, Ning K, Chen Y, Li L, El-Hayek YH, Gomez E, Zukin RS, Fehlings MG, Wan Q, J Neurosci 2006 26 5309 5319 10.1523/JNEUROSCI.0567-06.2006 16707783 (Pubitemid 44318383)
58. AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke. Soundarapandian MM, Tu WH, Peng PL, Zervos AS, Lu Y, Mol Neurobiol 2005 32 145 155 10.1385/MN:32:2:145 16215279 (Pubitemid 41397183)
59. Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate. Spaethling JM, Klein DM, Singh P, Meaney DF, J Neurotrauma 2008 25 1207 1216 10.1089/neu.2008.0532 18986222
60. Overexpression of Ca2+permeable AMPA receptor promotes delayed cell death of hippocampal CA1 neurons following transient forebrain ischemia. Anzai T, Tsuzuki K, Yamada N, Hayashi T, Iwakuma M, Inada K, Kameyama K, Hoka S, Saji M, Neurosci Res 2003 46 41 51 10.1016/S0168-0102(03)00023-3 12725911 (Pubitemid 36506608)
61. Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemia. Liu S, Lau L, Wei J, Zhu D, Zou S, Sun HS, Fu Y, Liu F, Lu Y, Neuron 2004 43 43 55 10.1016/j.neuron.2004.06.017 15233916 (Pubitemid 38952818)
62. Down-regulation of GluR2 is associated with Ca2+dependent protease activities in kainate-induced apoptotic cell death in cultured [correction of culturd] rat hippocampal neurons. Li SY, Ni JH, Xu DS, Jia HT, Neurosci Lett 2003 352 105 108 10.1016/j.neulet.2003.08.054 14625034 (Pubitemid 37415136)
63. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Dittmann K, Mayer C, Kehlbach R, Rodemann HP, Mol Cancer 2008 7 69 10.1186/1476-4598-7-69 18789131
64. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Liao HJ, Carpenter G, Mol Biol Cell 2007 18 1064 1072 10.1091/mbc.E06-09-0802 17215517 (Pubitemid 46399509)
65. Identification of low molecular weight GTP-binding proteins and their sites of interaction in subcellular fractions from skeletal muscle. Doucet JP, Tuana BS, J Biol Chem 1991 266 17613 17620 1910047 (Pubitemid 21907982)
66. Actin-severing activity copurifies with phosphofructokinase. Fuchtbauer A, Jockusch BM, Leberer E, Pette D, Proc Natl Acad Sci USA 1986 83 9502 9506 10.1073/pnas.83.24.9502 3025844 (Pubitemid 17223388)
67. Rapid plasmenylethanolamine-selective fusion of membrane bilayers catalyzed by an isoform of glyceraldehyde-3-phosphate dehydrogenase: discrimination between glycolytic and fusogenic roles of individual isoforms. Glaser PE, Gross RW, Biochemistry 1995 34 12193 12203 10.1021/bi00038a013 7547960
68. Bundling of microtubules by glyceraldehyde-3-phosphate dehydrogenase and its modulation by ATP. Huitorel P, Pantaloni D, Eur J Biochem 1985 150 265 269 10.1111/j.1432-1033.1985.tb09016.x 4018083 (Pubitemid 16237172)
69. Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase. Ikemoto A, Bole DG, Ueda T, J Biol Chem 2003 278 5929 5940 10.1074/jbc.M211617200 12488440 (Pubitemid 36800840)
70. A mutation in glyceraldehyde 3-phosphate dehydrogenase alters endocytosis in CHO cells. Robbins AR, Ward RD, Oliver C, J Cell Biol 1995 130 1093 1104 10.1083/jcb.130.5.1093 7657694
71. Glyceraldehyde-3-phosphate dehydrogenase is required for vesicular transport in the early secretory pathway. Tisdale EJ, J Biol Chem 2001 276 2480 2486 10.1074/jbc.M007567200 11035021
72. Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53. Chen RW, Saunders PA, Wei H, Li Z, Seth P, Chuang DM, J Neurosci 1999 19 9654 9662 10531467 (Pubitemid 30228116)
73. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. Lakkaraju A, Dubinsky JM, Low WC, Rahman YE, J Biol Chem 2001 276 32000 32007 10.1074/jbc.M100138200 11406618
74. p53 induction is associated with neuronal damage in the central nervous system. Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS, Proc Natl Acad Sci USA 1994 91 7525 7529 10.1073/pnas.91.16.7525 8052613 (Pubitemid 24238217)
75. Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Uberti D, Belloni M, Grilli M, Spano P, Memo M, Eur J Neurosci 1998 10 246 254 10.1046/j.1460-9568.1998.00042.x 9753133 (Pubitemid 28325446)
76. Neuronal life and death: an essential role for the p53 family. Miller FD, Pozniak CD, Walsh GS, Cell Death Differ 2000 7 880 888 10.1038/sj.cdd.4400736 11279533
77. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Brooks CL, Gu W, Curr Opin Cell Biol 2003 15 164 171 10.1016/S0955-0674(03)00003-6 12648672 (Pubitemid 36332191)
78. Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia. Colbourne F, Grooms SY, Zukin RS, Buchan AM, Bennett MV, Proc Natl Acad Sci USA 2003 100 2906 2910 10.1073/pnas.2628027100 12606709 (Pubitemid 36300753)
79. Induced hypothermia for acute stroke. Hemmen TM, Lyden PD, Stroke 2007 38 794 799 10.1161/01.STR.0000247920.15708.fa 17261741 (Pubitemid 46184261)
80. Hypothermia for the treatment of ischemic and hemorrhagic stroke. Linares G, Mayer SA, Crit Care Med 2009 37 243 S249 10.1097/CCM.0b013e3181aa5de1 19535954
81. Oxygen therapy in acute ischemic stroke-experimental efficacy and molecular mechanisms. Poli S, Veltkamp R, Curr Mol Med 2009 9 227 241 10.2174/156652409787581619 19275631
82. Stem cells for ischemic brain injury: a critical review. Burns TC, Verfaillie CM, Low WC, J Comp Neurol 2009 515 125 144 10.1002/cne.22038 19399885
83. A neurovascular niche for neurogenesis after stroke. Ohab JJ, Fleming S, Blesch A, Carmichael ST, J Neurosci 2006 26 13007 13016 10.1523/JNEUROSCI.4323- 06.2006 17167090 (Pubitemid 44954619)
84. Cerebral protection, brain repair, plasticity and cell therapy in ischemic stroke. Gutierrez M, Merino JJ, de Lecinana MA, Diez-Tejedor E, Cerebrovasc Dis 2009 27 Suppl 1 177 186 19342849
85. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Lee FJ, Xue S, Pei L, Vukusic B, Chery N, Wang Y, Wang YT, Niznik HB, Yu XM, Liu F, Cell 2002 111 219 230 10.1016/S0092-8674(02)00962-5 12408866 (Pubitemid 35292442)
86. Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors. Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB, Nature 2000 403 274 280 10.1038/35002014 10659839 (Pubitemid 30062376)
87. Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity. Zou S, Li L, Pei L, Vukusic B, Van Tol HH, Lee FJ, Wan Q, Liu F, J Neurosci 2005 25 4385 4395 10.1523/JNEUROSCI.5099-04.2005 15858065 (Pubitemid 40628783)
88. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH, Proc Natl Acad Sci USA 2006 103 3887 3889 10.1073/pnas.0511321103 16505364 (Pubitemid 43376650)