E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation

Molecular and Cellular Biochemistry

Volumn 366, Issue 1-2, 2012, Pages 123-129

  Carcagno, Abel L ^a   Giono, Luciana E ^a   Marazita, Mariela C ^a   Castillo, Daniela S ^a   Pregi, Nicolás ^a   Cánepa, Eduardo T ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

DNA damage response; E2F1; p19INK4d; Transcriptional regulation; UV irradiation

Indexed keywords

BETA TUBULIN; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; PROTEIN P191NK4D; TAMOXIFEN; TRANSCRIPTION FACTOR E2F2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PHASE; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE SEQUENCE; GENETIC TRANSFECTION; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; REGULATORY MECHANISM; RNA EXTRACTION; TRANSCRIPTION REGULATION; ULTRAVIOLET IRRADIATION; UPREGULATION;

ANIMALS; CELL CYCLE; CRICETINAE; CYCLIN-DEPENDENT KINASE INHIBITOR P19; DNA; DNA DAMAGE; DNA REPAIR; E2F1 TRANSCRIPTION FACTOR; HEK293 CELLS; HUMANS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; ULTRAVIOLET RAYS;

EID: 84862012591     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1289-8     Document Type: Article

References (28)

1. Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411(6835):366-374
2. Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-1672
3. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA (2002) Toward maintaining the genome: DNA damage and replication checkpoints. Ann Rev Genet 36:617-656 (Pubitemid 36109200)
4. Motoyama N, Naka K (2004) DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev 14(1):11-16 (Pubitemid 38173005)
5. Li L, Zou L (2005) Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem 94(2):298-306 (Pubitemid 41420308)
6. Attwooll C, Lazzerini Denchi E, Helin K (2004) The E2F family: specific functions and overlapping interests. EMBO J 23(24):4709-4716 (Pubitemid 40069701)
7. Lin WC, Lin FT, Nevins JR (2001) Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 15(14):1833-1844
8. Hallstrom TC, Mori S, Nevins JR (2008) An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13(1):11-22 (Pubitemid 350309738)
9. Carcagno AL, Ogara MF, Sonzogni SV, Marazita MC, Sirkin PF, Ceruti JM, Canepa ET (2009) E2F1 transcription is induced by genotoxic stress through ATM/ATR activation. IUBMB Life 61(5):537-543
10. Roussel MF (1999) The INK4 family of cell cycle inhibitors in cancer. Oncogene 18(38):5311-5317
11. Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF (2007) INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life 59(7):419-426 (Pubitemid 47123998)
12. Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET (2005) Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24(25):4065-4080 (Pubitemid 40897053)
13. Scassa ME, Marazita MC, Ceruti JM, Carcagno AL, Sirkin PF, Gonzalez-Cid M, Pignataro OP, Canepa ET (2007) Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair. DNA Repair (Amst) 6(5):626-638 (Pubitemid 46518331)
14. Park KK, Deok Ahn J, Lee IK, Magae J, Heintz NH, Kwak JY, Lee YC, Cho YS, Kim HC, Chae YM, Ho Kim Y, Kim CH, Chang YC (2003) Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP. Biochem Biophys Res Commun 308(4):689-697 (Pubitemid 36976518)
15. Giono LE, Varone CL, Canepa ET (2001) 5-Aminolevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB). Biochem J 353(Pt 2):307-316 (Pubitemid 32096940)
16. Carcagno AL, Marazita MC, Ogara MF, Ceruti JM, Sonzogni SV, Scassa ME, Giono LE, Canepa ET (2011) E2F1-Mediated Upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. PLoS ONE 6(7):e21938
17. Varone CL, Giono LE, Ochoa A, Zakin MM, Canepa ET (1999) Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase. Arch Biochem Biophys 372(2):261-270 (Pubitemid 30026775)
18. Varone CL, Canepa ET (1997) Evidence that protein kinase C is involved in delta-aminolevulinate synthase expression in rat hepatocytes. Arch Biochem Biophys 341(2):259-266 (Pubitemid 27203030)
19. Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15(5):2672-2681
20. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR (1997) Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 94(14):7245-7250 (Pubitemid 27345300)
21. Hitchens MR, Robbins PD (2003) The role of the transcription factor DP in apoptosis. Apoptosis 8(5):461-468 (Pubitemid 37247989)
22. Stevens C, Smith L, La Thangue NB (2003) Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 5(5):401-409 (Pubitemid 36592262)
23. Wang B, Liu K, Lin FT, Lin WC (2004) A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem 279(52):54140-54152 (Pubitemid 40053150)
24. Ceruti JM, Scassa ME, Marazita MC, Carcagno AC, Sirkin PF, Canepa ET (2009) Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response. Int J Biochem Cell Biol 41(6):1344-1353
25. Sherr CJ (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev 12(19):2984-2991
26. Iaquinta PJ, Aslanian A, Lees JA (2005) Regulation of the Arf/ p53 tumor surveillance network by E2F. Cold Spring Harb Symp Quant Biol 70:309-316 (Pubitemid 44124885)
27. Sherr CJ (2006) Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 6(9):663-673
28. Horn HF, Vousden KH (2007) Coping with stress: multiple ways to activate p53. Oncogene 26(9):1306-1316 (Pubitemid 46328472)