5-aminolaevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB)

Biochemical Journal

Volumn 353, Issue 2, 2001, Pages 307-316

  Giono, L E ^a   Varone, C L ^a   Canepa E T ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Gene expression; Haem biosynthesis; Hepatic cell; Protein kinase A; Transcription factor

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA;

ANIMAL CELL; ARTICLE; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEME SYNTHESIS; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; RAT; REPRESSOR GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

5-AMINOLEVULINATE SYNTHETASE; ANIMALS; BINDING SITES; CREB-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION; HUMANS; MUTATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PLASMIDS; PROMOTER REGIONS (GENETICS); RATS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA; FUNGI; MAMMALIA;

EID: 0035862980     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3530307     Document Type: Article

References (44)

1. Molecular regulation of heme biosynthesis in higher vertebrates
2. Heme production in animal tissues: The regulation of biogenesis of δ-aminolevulinate synthase
3. Molecular defects of erythroid 5-aminolevulinate synthase in X-linked sideroblastic anemia
4. Human delta-aminolevulinate synthase: Assignment of the house keeping gene to 3p21 and erythroid specific gene to the X chromosome
5. The porphyrias
6. Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene
7. Regulation of erythroid 5-aminolevulinate synthase expression during erythropoiesis
8. Cell biology of heme
9. Biochemistry of porphyria
10. Hemin administration to rats reduces levels of hepatic mRNAs for phenobarbitone-inducible enzymes
11. Cytochrome P450 and its interactions with the heme biosynthetic pathway
12. Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis
13. Cyclic AMP regulation of phenobarbital mediated induction of δ-aminolevulinate synthase mRNA in hepatocytes from normal and experimental-diabetic rats
14. Evidence that protein kinase C is involved in δ-aminolevulinate synthase expression in rat hepatocytes
15. Transcriptional regutation by cyclic AMP
16. The CREB family of transcription activators
17. Hormonal control of gene expression: Multiplicity and versatility of cyclic adenosine 3′,5′ -monophosphate-responsive nuclear regulators
18. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
19. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
20. Protein-kinase-A-dependent activator in transcription factor CREB reveals a new role for CREM repressors
21. CREB represses transcription of fos promoter: Role of phosphorylation
22. Impaired cyclic AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatine gone in an insulinoma cell line
23. The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators
24. Identification of regulatory sequences in the gone for 5-aminolevulithate synthase from rat
25. Structure and expression of the gene encoding rat nonspecific form of δ-aminolevulinate synthase
26. Matlnd and Matinspector-New fast and versatile tools for detection of consensus matches in nucleotide sequence data
27. Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase
28. Regulation of transcription by cyclic AMP-dependent protein kinase
29. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation
30. A simple phase-extraction assay for chloramphenicol acyltransferase activity
31. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
32. Two different genes encode delta-aminolevulinate synthase in humans: Nucteotide sequences of cDNAs for the housekeeping and erythroid genes
33. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
34. Hormone response units: One plus one equals more than two
35. Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes
36. Characterization of a cAMP-regulated enhancer-binding protein
37. Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein
38. Inducible binding of cyclic adenosine 3′,5′-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivo
39. Signaling routes to CREM and CREB: Plasticity in transcriptional activation
40. Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation
41. Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active
42. Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription
43. The CREB constitutive activation domain interacts with TATA-binding protein-associated factor 110 (TAF110) through specific hydrophobic residues in one of the three subdomains required for both activation and TAF110 binding