Regulation of the Arf/p53 tumor surveillance network by E2F

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 70, Issue , 2005, Pages 309-316

  Iaquinta, P J ^a   Aslanian, A ^a,b   Lees, J A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; MOUSE; NONHUMAN; PRIORITY JOURNAL; ARTICLE; CANCER EPIDEMIOLOGY; CELL STRESS; CHROMATIN IMMUNOPRECIPITATION; DNA TRANSCRIPTION; FIBROBLAST; GENE ACTIVATION; GENE OVEREXPRESSION; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; E2F TRANSCRIPTION FACTORS; E2F3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, RETINOBLASTOMA; GENES, TUMOR SUPPRESSOR; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 33746425213     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2005.70.050     Document Type: Conference Paper

References (61)

1. Adams M.R., Sears R., Nuckolls F., Leone G., and Nevins J.R. 2000. Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol. Cell. Biol. 20: 3633.
2. Aslanian A., Iaquinta P.J., Verona R., and Lees J.A. 2004. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 18: 1413.
3. Attwooll C., Oddi S., Cartwright P., Prosperini E., Agger K., Steensgaard P., Wagener C., Sardet C., Moroni M.C., and Helin K. 2005. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J. Biol. Chem. 280: 1199.
4. Baudino T.A., Maclean K.H., Brennan J., Parganas E., Yang C., Aslanian A., Lees J.A., Sherr C.J., Roussel M.F., and Cleveland J.L. 2003. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Mol. Cell 11: 905.
5. Ben-Israel H. and Kleinberger T. 2002. Adenovirus and cell cycle control. Front. Biosci. 7: d1369.
6. Berkovich E., Lamed Y., and Ginsberg D. 2003. E2F and Ras synergize in transcriptionally activating p14ARF expression. Cell Cycle 2: 127.
7. Cam H. and Dynlacht B.D. 2003. Emerging roles for E2F: Beyond the G1/S transition and DNA replication. Cancer Cell 3: 311.
8. Cam H., Balciunaite E., Blais A., Spektor A., Scarpulla R.C., Young R., Kluger Y., and Dynlacht B.D. 2004. A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16: 399.
9. Cartwright P., Muller H., Wagener C., Holm K., and Helin K. 1998. E2F-6: A novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 17: 611.
10. Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A.P., Trinh E., Heeran M., Di Stefano L., and Helin K. 2005. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res. 33: 5458.
11. de Bruin A., Maiti B., Jakoi L., Timmers C., Buerki R., and Leone G. 2003. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J. Biol. Chem. 278: 42041.
12. DeGregori J., Leone G., Miron A., Jakoi L., and Nevins J.R. 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. 94: 7245.
13. Denchi E.L. and Helin K. 2005. E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep. 6: 661.
14. de Stanchina E., McCurrach M.E., Zindy F., Shieh S.Y., Ferbeyre G., Samuelson A.V., Prives C., Roussel M.F., Sherr C.J., and Lowe S.W. 1998. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev. 12: 2434.
15. Dick F.A. and Dyson N. 2003. pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol. Cell 12: 639.
16. Dimova D.K. and Dyson N.J. 2005. The E2F transcriptional network: Old acquaintances with new faces. Oncogene 24: 2810.
17. Di Stefano L., Jensen M.R., and Helin K. 2003. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J. 22: 6289.
18. Gaubatz S., Lees J.A., Lindeman G.J., and Livingston D.M. 2001. E2F4 is exported from the nucleus in a CRM1-dependent manner. Mol. Cell. Biol. 21: 1384.
19. Gaubatz S., Lindeman G.J., Ishida S., Jakoi L., Nevins J.R., Livingston D.M., and Rempel R.E. 2000. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol. Cell 6: 729.
20. Gil J., Bernard D., Martinez D., and Beach D. 2004. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 6: 67.
21. Hanahan D. and Weinberg R.A. 2000. The hallmarks of cancer. Cell 100: 57.
22. He Y., Armanious M.K., Thomas M.J., and Cress W.D. 2000. Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region. Oncogene 19: 3422.
23. Hiebert S.W., Packham G., Strom D.K., Haffner R., Oren M., Zambetti G., and Cleveland J.L. 1995. E2F-1: DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol. Cell. Biol. 15: 6864.
24. Hsieh J.K., Fredersdorf S., Kouzarides T., Martin K., and Lu X. 1997. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11: 1840.
25. Humbert P.O., Verona R., Trimarchi J.M., Rogers C., Dandapani S., and Lees J.A. 2000. E2f3 is critical for normal cellular proliferation. Genes Dev. 14: 690.
26. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. 1999. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164.
27. Johnson D.G., Cress W.D., Jakoi L., and Nevins J.R. 1994. Oncogenic capacity of the E2F1 gene. Proc. Natl. Acad. Sci. 91: 12823.
28. Landsberg R.L., Sero J.E., Danielian P.S., Yuan T.L., Lee E.Y., and Lees J.A. 2003. The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proc. Natl. Acad. Sci. 100: 2456.
29. Lees J.A., Saito M., Vidal M., Valentine M., Look T., Harlow E., Dyson N., and Helin K. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 13: 7813.
30. Leone G., Nuckolls F., Ishida S., Adams M., Sears R., Jakoi L., Miron A., and Nevins J.R. 2000. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol. Cell. Biol. 20: 3626.
31. Leone G., Sears R., Huang E., Rempel R., Nuckolls F., Park C.H., Giangrande P., Wu L., Saavedra H.I., Field S.J., Thompson M.A., Yang H., Fujiwara Y., Greenberg M.E., Orkin S., Smith C., and Nevins J.R. 2001. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol. Cell 8: 105.
32. Lukas J., Petersen B.O., Holm K., Bartek J., and Helin K. 1996. Deregulated expression of E2F family members induces Sphase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16: 1047.
33. Maiti B., Li J., de Bruin A., Gordon F., Timmers C., Opavsky R., Patil K., Tuttle J., Cleghorn W., and Leone G. 2005. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J. Biol. Chem. 280: 18211.
34. McCaffrey J., Yamasaki L., Dyson N.J., Harlow E., and Griep A.E. 1999. Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol. Cell. Biol. 19: 6458.
35. Moberg K., Starz M.A., and Lees J.A. 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436.
36. Morkel M., Wenkel J., Bannister A.J., Kouzarides T., and Hagemeier C. 1997. An E2F-like repressor of transcription. Nature 390: 567.
37. Morris E.J. and Dyson N.J. 2001. Retinoblastoma protein partners. Adv. Cancer Res. 82: 1.
38. Ogawa H., Ishiguro K., Gaubatz S., Livingston D.M., and Nakatani Y. 2002. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296: 1132.
39. Palmero I., Murga M., Zubiaga A., and Serrano M. 2002. Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Oncogene 21: 2939.
40. Pan H., Yin C., Dyson N.J., Harlow E., Yamasaki L., and Van Dyke T. 1998. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2: 283.
41. Parisi T., Pollice A., Di Cristofano A., Calabro V., and La Mantia G. 2002. Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors. Biochem. Biophys. Res. Commun. 291: 1138.
42. Phillips A.C. and Vousden K.H. 2001. E2F-1 induced apoptosis. Apoptosis 6: 173.
43. Phillips A.C., Bates S., Ryan K.M., Helin K., and Vousden K.H. 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11: 1853.
44. Phillips A.C., Ernst M.K., Bates S., Rice N.R., and Vousden K.H. 1999. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol. Cell 4: 771.
45. Qin X.Q., Livingston D.M., Kaelin W.G., Jr., and Adams P.D. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91: 10918.
46. Ren B., Cam H., Takahashi Y., Volkert T., Terragni J., Young R.A., and Dynlacht B.D. 2002. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16: 245.
47. Serrano M., Lee H., Chin L., Cordon-Cardo C., Beach D., and DePinho R.A. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27.
48. Sherr C.J. 1996. Cancer cell cycles. Science 274: 1672.
49. _. 2001. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2: 731.
50. Sherr C.J. and Weber J.D. 2000. The ARF/p53 pathway. Curr. Opin. Genet. Dev. 10: 94.
51. Sreeramaneni R., Chaudhry A., McMahon M., Sherr C.J., and Inoue K. 2005. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Mol. Cell. Biol. 25: 220.
52. Takahashi Y., Rayman J.B., and Dynlacht B.D. 2000. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression. Genes Dev. 14: 804.
53. Trimarchi J.M. and Lees J.A. 2002. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3: 11.
54. Trimarchi J.M., Fairchild B., Wen J., and Lees J.A. 2001. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. 98: 1519.
55. Trimarchi J.M., Fairchild B., Verona R., Moberg K., Andon N., and Lees J.A. 1998. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. 95: 2850.
56. Verona R., Moberg K., Estes S., Starz M., Vernon J.P., and Lees J.A. 1997. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17: 7268.
57. Vigo E., Muller H., Prosperini E., Hateboer G., Cartwright P., Moroni M.C., and Helin K. 1999. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol. Cell. Biol. 19: 6379.
58. Wu X. and Levine A.J. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. 91: 3602.
59. Yamasaki L., Bronson R., Williams B.O., Dyson N.J., Harlow E., and Jacks T. 1998. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat. Genet. 18: 360.
60. Ziebold U., Lee E.Y., Bronson R.T., and Lees J.A. 2003. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol. Cell. Biol. 23: 6542.
61. Zindy F., Williams R.T., Baudino T.A., Rehg J.E., Skapek S.X., Cleveland J.L., Roussel M.F., and Sherr C.J. 2003. Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc. Natl. Acad. Sci. 100: 15930.