Claudins and alveolar epithelial barrier function in the lung

Annals of the New York Academy of Sciences

Volumn 1257, Issue 1, 2012, Pages 175-183

  Frank, James A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute lung injury; Alveolar epithelium; Cancer; Claudin; Tight junction

Indexed keywords

CLAUDIN; CLAUDIN 18; CLAUDIN 3;

ACUTE LUNG INJURY; FIBROSING ALVEOLITIS; GAS DIFFUSION; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG FUNCTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TIGHT JUNCTION;

EID: 84861991342     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06533.x     Document Type: Review

References (64)

1. Tsukita, S., Y. Yamazaki, T. Katsuno & A. Tamura. 2008. Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27: 6930-6938.
2. Gorin, A.B. & P.A. Stewart. 1979. Differential permeability of endothelial and epithelial barriers to albumin flux. J. Appl. Physiol. 47: 1315-1324.
3. Vreim, C.R., P.D. Snashall, R.H. Demling & N.C. Staub. 1976. Lung lymph and free interstitial fluid protein composition in sheep with edema. Am. J. Physiol. 230: 1650-1653.
4. Matthay, M.A., H.G. Folkesson & C. Clerici. 2002. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol. Rev. 82: 569-600.
5. Matthay, M.A., L. Robriquet & X. Fang. 2005. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc. Am. Thorac. Soc. 2: 206-213.
6. Fang, X., Y. Song, J. Hirsch, et al. 2006. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L242-L249.
7. Fang, X., N. Fukuda, P. Barbry, et al. 2002. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J. Gen. Physiol. 119: 199-207.
8. Kim, K.J., J.M. Cheek & E.D. Crandall. 1991. Contribution of active Na+ and Cl- fluxes to net ion transport by alveolar epithelium. Respir. Physiol. 85: 245-256.
9. Verkman, A.S., M.A. Matthay & Y. Song. 2000. Aquaporin water channels and lung physiology. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L867-L879.
10. Ware, L.B. & M.A. Matthay. 2001. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 163: 1376-1383.
11. LaFemina, M.J., D. Rokkam, A. Chandrasena, et al. 2010. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 299: L724-L734.
12. Tureci, O., M. Koslowski, G. Helftenbein, et al. 2011. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene 481: 83-92.
13. Sung, S.S., S.M. Fu, C.E. Rose, Jr., et al. 2006. A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J. Immunol. 176: 2161-2172.
14. Fujita, H., M. Chalubinski, C. Rhyner, et al. 2011. Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects. J. Allergy Clin. Immunol. 127: 1612-1621.
15. Morita, K., H. Sasaki, M. Furuse & S. Tsukita. 1999. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J. Cell. Biol. 147: 185-194.
16. Wray, C., Y. Mao, J. Pan, et al. 2009. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L219-227.
17. Fang, X., A.P. Neyrinck, M.A. Matthay & J.W. Lee. 2010. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J. Biol. Chem. 285: 26211-26222.
18. Ohta, H., S. Chiba, M. Ebina, M. Furuse & T. Nukiwa. 2012. Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 302: L193-L205.
19. Werth, M., K. Walentin, A. Aue, et al. 2010. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137: 3835-3845.
20. Ikari, A., K. Atomi, A. Takiguchi, et al. 2009. Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochem. Biophys. Res. Commun. 384: 306-310.
21. Honda, H., M.J. Pazin, H. Ji, R.P. Wernyj & P.J. Morin. 2006. Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J. Biol. Chem. 281: 21433-21444.
22. Singh, A.B. & R.C. Harris. 2004. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J. Biol. Chem. 279: 3543-3552.
23. Lamb-Rosteski, J.M., L.D. Kalischuk, G.D. Inglis & A.G. Buret. 2008. Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation. Infect. Immun. 76: 3390-3398.
24. Myers, M.V., H.C. Manning, R.J. Coffey & D.C. Liebler. 2012. Protein expression signatures for inhibition of epidermal growth factor receptor mediated signaling. Mol. Cell. Proteomics 11: M111.015222.
25. Terakado, M., Y. Gon, A. Sekiyama, et al. 2011. The Rac1/JNK pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 300: L56-L63.
26. Jia, D., R. Rahbar & E.N. Fish. 2007. Interferon-inducible Stat2 activation of JUND and CLDN4: mediators of IFN responses. J. Interferon. Cytokine. Res. 27: 559-565.
27. Amasheh, M., S. Schlichter, S. Amasheh, et al. 2008. Quercetin enhances epithelial barrier function and increases claudin-4 expression in caco-2 cells. J. Nutr. 138: 1067-1073.
28. Van Itallie, C., C. Rahner & J.M. Anderson. 2001. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J. Clin. Invest. 107: 1319-1327.
29. Ohta, A., S.S. Yang, T. Rai, et al. 2006. Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem. Biophys. Res. Commun. 349: 804-808.
30. Rokkam, D., M.J. Lafemina, J.W. Lee, M.A. Matthay & J.A. Frank. 2011. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am. J. Pathol. 179: 1081-1087.
31. Frank, J.A., R. Briot, J.W. Lee, et al. 2007. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L52-L59.
32. Murray, J.F., M.A. Matthay, J.M. Luce & M.R. Flick. 1988. An expanded definition of the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 138: 720-723.
33. Mitchell, L.A., C.E. Overgaard, C. Ward, S.S. Margulies & M. Koval. 2011. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function. Am. J. Physiol. Lung Cell. Mol. Physiol. 301: L40-L49.
34. Snyder, J.C., A.C. Zemke & B.R. Stripp. 2009. Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix. Am. J. Respir. Cell. Mol. Biol. 40: 633-642.
35. Inoue, K., M. Oyamada, S. Mitsufuji, T. Okanoue & T. Takamatsu. 2006. Different changes in the expression of multiple kinds of tight-junction proteins during ischemia-reperfusion injury of the rat ileum. Acta. Histochem. Cytochem. 39: 35-45.
36. Kreft, M.E., M. Sterle & K. Jezernik. 2006. Distribution of junction- and differentiation-related proteins in urothelial cells at the leading edge of primary explant outgrowths. Histochem. Cell. Biol. 125: 475-485.
37. Ewert, P., S. Aguilera, C. Alliende, et al. 2010. Disruption of tight junction structure in salivary glands from Sjogren's syndrome patients is linked to proinflammatory cytokine exposure. Arthritis Rheum. 62: 1280-1289.
38. Michikawa, H., J. Fujita-Yoshigaki & H. Sugiya. 2008. Enhancement of barrier function by overexpression of claudin-4 in tight junctions of submandibular gland cells. Cell Tissue Res. 334: 255-264.
39. Fujita-Yoshigaki, J. 2011. Analysis of changes in the expression pattern of claudins using salivary acinar cells in primary culture. Methods Mol. Biol. 762: 245-258.
40. Moriwaki, K., S. Tsukita & M. Furuse. 2007. Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. Dev. Biol. 312: 509-522.
41. Lanaspa, M.A., A. Andres-Hernando, C.J. Rivard, Y. Dai & T. Berl. 2008. Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells. Proc. Natl. Acad. Sci. USA 105: 15797-15802.
42. Agarwal, R., T. D'Souza & P.J. Morin. 2005. Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res. 65: 7378-7385.
43. Boireau, S., M. Buchert, M.S. Samuel, et al. 2007. DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis 28: 246-258.
44. Cunningham, S.C., F. Kamangar, M.P. Kim, et al. 2006. Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions. Cancer Epidemiol. Biomarkers Prev. 15: 281-287.
45. Halder, S.K., G. Rachakonda, N.G. Deane & P.K. Datta. 2008. Smad7 induces hepatic metastasis in colorectal cancer. Br. J. Cancer 99: 957-965.
46. Hanada, S., A. Maeshima, Y. Matsuno, et al. 2008. Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression. J. Pathol. 216: 75-82.
47. Hough, C.D., C.A. Sherman-Baust, E.S. Pizer, et al. 2000. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res. 60: 6281-6287.
48. Kleinberg, L., A. Holth, C.G. Trope, R. Reich & B. Davidson. 2008. Claudin upregulation in ovarian carcinoma effusions is associated with poor survival. Hum. Pathol. 39: 747-757.
49. Landers, K.A., H. Samaratunga, L. Teng, et al. 2008. Identification of claudin-4 as a marker highly overexpressed in both primary and metastatic prostate cancer. Br. J. Cancer 99: 491-501.
50. Lanigan, F., E. McKiernan, D.J. Brennan, et al. 2009. Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int. J. Cancer 124: 2088-2097.
51. Li, J., S. Chigurupati, R. Agarwal, et al. 2009. Possible angiogenic roles for claudin-4 in ovarian cancer. Cancer Biol. Ther. 8: 1806-1814.
52. Michl, P., C. Barth, M. Buchholz, et al. 2003. Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res. 63: 6265-6271.
53. Seckin, Y., S. Arici, M. Harputluoglu, et al. 2009. Expression of claudin-4 and beta-catenin in gastric premalignant lesions. Acta. Gastroenterol. Belg. 72: 407-412.
54. Tsutsumi, K., N. Sato, L. Cui, et al. 2011. Expression of claudin-4 (CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas. Mod. Pathol. 24: 533-541.
55. Lonardi, S., C. Manera, R. Marucci, et al. 2011. Usefulness of claudin 4 in the cytological diagnosis of serosal effusions. Diagn. Cytopathol. 39: 313-317.
56. Facchetti, F., S. Lonardi, F. Gentili, et al. 2007. Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions. Virchows. Arch. 451: 669-680.
57. Konecny, G.E., R. Agarwal, G.A. Keeney, et al. 2008. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol. Oncol. 109: 263-269.
58. Lee, L.Y., C.M. Wu, C.C. Wang, et al. 2008. Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression. Histol. Histopathol. 23: 515-521.
59. Blanchard, A.A., G.P. Skliris, P.H. Watson, et al. 2009. Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype. Virchows. Arch. 454: 647-656.
60. Kulka, J., A.M. Szasz, Z. Nemeth, et al. 2009. Expression of tight junction protein claudin-4 in basal-like breast carcinomas. Pathol. Oncol. Res. 15: 59-64.
61. Szasz, A.M., Z. Nemeth, B. Gyorffy, et al. 2011. Identification of a claudin-4 and E-cadherin score to predict prognosis in breast cancer. Cancer Sci. 102: 2248-2254.
62. Milatz, S., S.M. Krug, R. Rosenthal, et al. 2010. Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta. 1798: 2048-2057.
63. Daugherty, B.L., C. Ward, T. Smith, et al. 2007. Regulation of heterotypic claudin compatibility. J. Biol. Chem. 282: 30005-30013.
64. Hayashi, D., A. Tamura, H. Tanaka, et al. 2012. Deficiency of claudin-18 causes paracellular H(+) leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice. Gastroenterology 142: 292-304.