메뉴 건너뛰기




Volumn 4, Issue 1, 2012, Pages 30-39

Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury

Author keywords

3 nitrotyrosine; Acute lung injury; Apoptosis; Nitric oxide; Peroxynitrite; Reactive oxygen species; Rho kinase; Rock; Sepsis

Indexed keywords


EID: 84861959861     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2010.08.04     Document Type: Article
Times cited : (36)

References (50)
  • 1
    • 0034924156 scopus 로고    scopus 로고
    • Epidemiology of sepsis: an update
    • Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001;29:S109-16.
    • (2001) Crit Care Med , vol.29
    • Angus, D.C.1    Wax, R.S.2
  • 2
    • 34347397197 scopus 로고    scopus 로고
    • Advances in pathogenesis and management of sepsis
    • Cinel I, Dellinger RP. Advances in pathogenesis and management of sepsis. Curr Opin Infect Dis 2007;20:345-52.
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 345-352
    • Cinel, I.1    Dellinger, R.P.2
  • 3
    • 59649117667 scopus 로고    scopus 로고
    • Molecular biology of inflammation and sepsis: a primer
    • Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a primer. Crit Care Med 2009;37:291-304.
    • (2009) Crit Care Med , vol.37 , pp. 291-304
    • Cinel, I.1    Opal, S.M.2
  • 5
    • 0036417213 scopus 로고    scopus 로고
    • The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis
    • Cinel I, Buyukafsar K, Cinel L, Polat A, Atici S, Tamer L, et al. The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. Pharmacol Res 2002;46:119-27.
    • (2002) Pharmacol Res , vol.46 , pp. 119-127
    • Cinel, I.1    Buyukafsar, K.2    Cinel, L.3    Polat, A.4    Atici, S.5    Tamer, L.6
  • 6
    • 0037084074 scopus 로고    scopus 로고
    • Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States
    • Bersten AD, Edibam C, Hunt T, Moran J. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States. Am J Respir Crit Care Med 2002;165:443-8.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 443-448
    • Bersten, A.D.1    Edibam, C.2    Hunt, T.3    Moran, J.4
  • 8
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-50.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 9
    • 0038113408 scopus 로고    scopus 로고
    • The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model
    • Ozdulger A, Cinel I, Koksel O, Cinel L, Avlan D, Unlu A, et al. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock 2003;19:366-72.
    • (2003) Shock , vol.19 , pp. 366-372
    • Ozdulger, A.1    Cinel, I.2    Koksel, O.3    Cinel, L.4    Avlan, D.5    Unlu, A.6
  • 10
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998;279:509-14.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 11
    • 9244257348 scopus 로고    scopus 로고
    • Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    • Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J 1996;15:2208-16.
    • (1996) EMBO J , vol.15 , pp. 2208-2216
    • Matsui, T.1    Amano, M.2    Yamamoto, T.3    Chihara, K.4    Nakafuku, M.5    Ito, M.6
  • 12
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: multifunctional kinases in cell behaviour
    • Riento K, Ridley AJ. Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 2003;4:446-56.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 13
    • 0035150402 scopus 로고    scopus 로고
    • Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
    • Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 2001;22:32-9.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 32-39
    • Fukata, Y.1    Amano, M.2    Kaibuchi, K.3
  • 14
    • 20044374702 scopus 로고    scopus 로고
    • Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor Y-27632
    • Tasaka S, Koh H, Yamada W, Shimizu M, Ogawa Y, Hasegawa N, et al. Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632. Am J Respir Cell Mol Biol 2005;32:504-10.
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 504-510
    • Tasaka, S.1    Koh, H.2    Yamada, W.3    Shimizu, M.4    Ogawa, Y.5    Hasegawa, N.6
  • 15
    • 0033960425 scopus 로고    scopus 로고
    • Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo
    • Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, et al. Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J 2000;14:418-29.
    • (2000) FASEB J , vol.14 , pp. 418-429
    • Ozaki, M.1    Deshpande, S.S.2    Angkeow, P.3    Bellan, J.4    Lowenstein, C.J.5    Dinauer, M.C.6
  • 16
    • 0036073008 scopus 로고    scopus 로고
    • ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton
    • Song Y, Hoang BQ, Chang DD. ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. Exp Cell Res 2002;278:45-52.
    • (2002) Exp Cell Res , vol.278 , pp. 45-52
    • Song, Y.1    Hoang, B.Q.2    Chang, D.D.3
  • 17
    • 4143103622 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats
    • Shiotani S, Shimada M, Suehiro T, Soejima Y, Yosizumi T, Shimokawa H, et al. Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats. Transplantation 2004;78:375-82.
    • (2004) Transplantation , vol.78 , pp. 375-382
    • Shiotani, S.1    Shimada, M.2    Suehiro, T.3    Soejima, Y.4    Yosizumi, T.5    Shimokawa, H.6
  • 18
    • 0027378613 scopus 로고
    • Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils
    • Arai M, Sasaki Y, Nozawa R. Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem Pharmacol 1993;46:1487-90.
    • (1993) Biochem Pharmacol , vol.46 , pp. 1487-1490
    • Arai, M.1    Sasaki, Y.2    Nozawa, R.3
  • 19
    • 0142120102 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system
    • Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, et al. Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 2003;93:767-75.
    • (2003) Circ Res , vol.93 , pp. 767-775
    • Higashi, M.1    Shimokawa, H.2    Hattori, T.3    Hiroki, J.4    Mukai, Y.5    Morikawa, K.6
  • 20
    • 0035072953 scopus 로고    scopus 로고
    • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
    • Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001;3:339-45.
    • (2001) Nat Cell Biol , vol.3 , pp. 339-345
    • Coleman, M.L.1    Sahai, E.A.2    Yeo, M.3    Bosch, M.4    Dewar, A.5    Olson, M.F.6
  • 21
    • 12444290153 scopus 로고    scopus 로고
    • Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells
    • Morelli A, Chiozzi P, Chiesa A, Ferrari D, Sanz JM, Falzoni S, et al. Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Mol Biol Cell 2003;14:2655-64.
    • (2003) Mol Biol Cell , vol.14 , pp. 2655-2664
    • Morelli, A.1    Chiozzi, P.2    Chiesa, A.3    Ferrari, D.4    Sanz, J.M.5    Falzoni, S.6
  • 22
    • 13644252220 scopus 로고    scopus 로고
    • Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
    • Sebbagh M, Hamelin J, Bertoglio J, Solary E, Bréard J. Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med 2005;201:465-71.
    • (2005) J Exp Med , vol.201 , pp. 465-471
    • Sebbagh, M.1    Hamelin, J.2    Bertoglio, J.3    Solary, E.4    Bréard, J.5
  • 23
    • 12344297303 scopus 로고    scopus 로고
    • Rho-associated protein kinase II (rock II) expression in normal and preeclamptic human placentas
    • Ark M, Yilmaz N, Yazici G, Kubat H, Aktaş S. Rho-associated protein kinase II (rock II) expression in normal and preeclamptic human placentas. Placenta 2005;26:81-4.
    • (2005) Placenta , vol.26 , pp. 81-84
    • Ark, M.1    Yilmaz, N.2    Yazici, G.3    Kubat, H.4    Aktaş, S.5
  • 24
    • 0028636503 scopus 로고
    • Lipid peroxides and related radicals in clinical medicine
    • Armstrong D ed. Plenum Press New York
    • Yagi K: Lipid peroxides and related radicals in clinical medicine. In: Armstrong D ed. Free Radicals in Diagnostic Medicine. Plenum Press New York 1994;pp 1-15.
    • (1994) Free Radicals in Diagnostic Medicine , pp. 1-15
    • Yagi, K.1
  • 25
    • 5144232462 scopus 로고    scopus 로고
    • N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury
    • Koksel O, Cinel I, Tamer L, Cinel L, Ozdulger A, Kanik A, et al. N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury. Pulm Pharmacol Ther 2004;17:263-70.
    • (2004) Pulm Pharmacol Ther , vol.17 , pp. 263-270
    • Koksel, O.1    Cinel, I.2    Tamer, L.3    Cinel, L.4    Ozdulger, A.5    Kanik, A.6
  • 26
    • 14644390298 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats
    • Koksel O, Yildirim C, Cinel L, Tamer L, Ozdulger A, Bastürk M, et al. Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats. Pharmacol Res 2005;51:453-62.
    • (2005) Pharmacol Res , vol.51 , pp. 453-462
    • Koksel, O.1    Yildirim, C.2    Cinel, L.3    Tamer, L.4    Ozdulger, A.5    Bastürk, M.6
  • 28
    • 1342283073 scopus 로고    scopus 로고
    • Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability
    • Breslin JW, Yuan SY. Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability. Am J Physiol Heart Circ Physiol 2004;286:H1057-62.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Breslin, J.W.1    Yuan, S.Y.2
  • 30
    • 0036826835 scopus 로고    scopus 로고
    • Endothelial Rho Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation
    • Saito H, Minamiya Y, Saito S, Ogawa J. Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation. J Leukoc Biol 2002;72:829-36.
    • (2002) J Leukoc Biol , vol.72 , pp. 829-836
    • Saito, H.1    Minamiya, Y.2    Saito, S.3    Ogawa, J.4
  • 31
    • 33745326435 scopus 로고    scopus 로고
    • Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury
    • Thorlacius K, Slotta JE, Laschke MW, Wang Y, Menger MD, Jeppsson B, et al. Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury. J Leukoc Biol 2006;79:923-31.
    • (2006) J Leukoc Biol , vol.79 , pp. 923-931
    • Thorlacius, K.1    Slotta, J.E.2    Laschke, M.W.3    Wang, Y.4    Menger, M.D.5    Jeppsson, B.6
  • 32
    • 33644861973 scopus 로고    scopus 로고
    • Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage
    • Breslin JW, Sun H, Xu W, Rodarte C, Moy AB, Wu MH, et al. Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage. Am J Physiol Heart Circ Physiol 2006;290:H741-50.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Breslin, J.W.1    Sun, H.2    Xu, W.3    Rodarte, C.4    Moy, A.B.5    Wu, M.H.6
  • 33
    • 34447638730 scopus 로고    scopus 로고
    • RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs
    • Gorovoy M, Neamu R, Niu J, Vogel S, Predescu D, Miyoshi J, et al. RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs. Circ Res 2007;101:50-8.
    • (2007) Circ Res , vol.101 , pp. 50-58
    • Gorovoy, M.1    Neamu, R.2    Niu, J.3    Vogel, S.4    Predescu, D.5    Miyoshi, J.6
  • 34
    • 0037119432 scopus 로고    scopus 로고
    • Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells
    • Cummings RJ, Parinandi NL, Zaiman A, Wang L, Usatyuk PV, Garcia JG, et al. Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem 2002;277:30227-35.
    • (2002) J Biol Chem , vol.277 , pp. 30227-30235
    • Cummings, R.J.1    Parinandi, N.L.2    Zaiman, A.3    Wang, L.4    Usatyuk, P.V.5    Garcia, J.G.6
  • 35
    • 2942746318 scopus 로고    scopus 로고
    • Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling
    • Zeng W, Matter WF, Yan SB, Um SL, Vlahos CJ, Liu L. Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling. Crit Care Med 2004;32:S302-8.
    • (2004) Crit Care Med , vol.32
    • Zeng, W.1    Matter, W.F.2    Yan, S.B.3    Um, S.L.4    Vlahos, C.J.5    Liu, L.6
  • 36
    • 0038746767 scopus 로고    scopus 로고
    • The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability
    • Petrache I, Birukova A, Ramirez SI, Garcia JG, Verin AD. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am J Respir Cell Mol Biol 2003;28:574-81.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 574-581
    • Petrache, I.1    Birukova, A.2    Ramirez, S.I.3    Garcia, J.G.4    Verin, A.D.5
  • 37
    • 21844450693 scopus 로고    scopus 로고
    • Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction
    • Birukova AA, Birukov KG, Adyshev D, Usatyuk P, Natarajan V, Garcia JG, et al. Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction. J Cell Physiol 2005;204:934-47.
    • (2005) J Cell Physiol , vol.204 , pp. 934-947
    • Birukova, A.A.1    Birukov, K.G.2    Adyshev, D.3    Usatyuk, P.4    Natarajan, V.5    Garcia, J.G.6
  • 38
    • 0034819755 scopus 로고    scopus 로고
    • Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung
    • Chiba Y, Ishii Y, Kitamura S, Sugiyama Y. Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung. Microvasc Res 2001;62:164-71.
    • (2001) Microvasc Res , vol.62 , pp. 164-171
    • Chiba, Y.1    Ishii, Y.2    Kitamura, S.3    Sugiyama, Y.4
  • 39
    • 33746255660 scopus 로고    scopus 로고
    • Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway
    • Thomas RA, Norman JC, Huynh TT, Williams B, Bolton SJ, Wardlaw AJ. Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway. Respir Med 2006;100:1588-97.
    • (2006) Respir Med , vol.100 , pp. 1588-1597
    • Thomas, R.A.1    Norman, J.C.2    Huynh, T.T.3    Williams, B.4    Bolton, S.J.5    Wardlaw, A.J.6
  • 40
    • 14244251637 scopus 로고    scopus 로고
    • The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle
    • Lundblad C, Bentzer P, Grände PO. The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle. Microvasc Res 2004;68:286-94.
    • (2004) Microvasc Res , vol.68 , pp. 286-294
    • Lundblad, C.1    Bentzer, P.2    Grände, P.O.3
  • 41
    • 18544375472 scopus 로고    scopus 로고
    • Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide
    • Ho YS, Liou HB, Lin JK, Jeng JH, Pan MH, Lin YP, et al. Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide. Arch Toxicol 2002;76:484-93.
    • (2002) Arch Toxicol , vol.76 , pp. 484-493
    • Ho, Y.S.1    Liou, H.B.2    Lin, J.K.3    Jeng, J.H.4    Pan, M.H.5    Lin, Y.P.6
  • 43
    • 0031822063 scopus 로고    scopus 로고
    • Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation
    • Virág L, Scott GS, Cuzzocrea S, Marmer D, Salzman AL, Szabó C. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology 1998;94:345-55.
    • (1998) Immunology , vol.94 , pp. 345-355
    • Virág, L.1    Scott, G.S.2    Cuzzocrea, S.3    Marmer, D.4    Salzman, A.L.5    Szabó, C.6
  • 44
    • 33749233824 scopus 로고    scopus 로고
    • Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
    • Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, et al. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A 2006;103:14495-500.
    • (2006) Proc Natl Acad Sci U SA , vol.103 , pp. 14495-14500
    • Chang, J.1    Xie, M.2    Shah, V.R.3    Schneider, M.D.4    Entman, M.L.5    Wei, L.6
  • 45
    • 0037439232 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3
    • Bao F, Liu D. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience 2003;116:59-70.
    • (2003) Neuroscience , vol.116 , pp. 59-70
    • Bao, F.1    Liu, D.2
  • 47
    • 1042266645 scopus 로고    scopus 로고
    • Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways
    • Walford GA, Moussignac RL, Scribner AW, Loscalzo J, Leopold JA. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. J Biol Chem 2004;279:4425-32.
    • (2004) J Biol Chem , vol.279 , pp. 4425-4432
    • Walford, G.A.1    Moussignac, R.L.2    Scribner, A.W.3    Loscalzo, J.4    Leopold, J.A.5
  • 48
    • 18144418144 scopus 로고    scopus 로고
    • Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    • Turner NA, O'Regan DJ, Ball SG, Porter KE. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J 2005;19:804-6.
    • (2005) FASEB J , vol.19 , pp. 804-806
    • Turner, N.A.1    O'Regan, D.J.2    Ball, S.G.3    Porter, K.E.4
  • 49
    • 29844445926 scopus 로고    scopus 로고
    • Statin therapy is associated with fewer deaths in patients with bacteraemia
    • Kruger P, Fitzsimmons K, Cook D, Jones M, Nimmo G. Statin therapy is associated with fewer deaths in patients with bacteraemia. Intensive Care Med 2006;32:75-9.
    • (2006) Intensive Care Med , vol.32 , pp. 75-79
    • Kruger, P.1    Fitzsimmons, K.2    Cook, D.3    Jones, M.4    Nimmo, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.