Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway

Respiratory Medicine

Volumn 100, Issue 9, 2006, Pages 1588-1597

  Thomas, R A ^a   Norman, J C ^a   Huynh, T T ^a   Williams, B ^a   Bolton, S J ^a   Wardlaw, A J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Bronchial epithelial cells; Cytokines; Mechanotransduction; Rho kinase; Stretch

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; CYTOKINE; INTEGRIN; INTERLEUKIN 8; PAXILLIN; RANTES; RHO KINASE; RHO KINASE INHIBITOR; RNA;

ARTICLE; BRONCHUS MUCOSA; CELL ADHESION; CELL ELONGATION; CELL FUNCTION; CELL LINE; CYTOKINE RELEASE; CYTOSKELETON; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MECHANICAL STRESS; MECHANOTRANSDUCTION; MEDIATOR RELEASE; MODEL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRETCHING;

AMIDES; BRONCHI; CELL LINE; CHEMOKINE CCL5; ELASTICITY; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; PAXILLIN; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RANTES; RHO-ASSOCIATED KINASES; STRESS, MECHANICAL;

EID: 33746255660     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2005.12.008     Document Type: Article

References (41)

1. Mills, Davies R., and Devalia J. Airway epithelial cells, cytokines, and pollutants. Am J Respir Crit Care Med 160 (1999) 38-43
2. Raeburn D., and Webber S. Proinflammatory potential of the airway epithelium in bronchial asthma. Eur Respir J 7 (1994) 2226-2233
3. Rennard S., Romberger D., Sisson J., Von Essen S., Rubinstein I., Robbins R., et al. Airway epithelial cells: functional roles in airway disease. Am J Respir Crit Care Med 150 (1994) 27-30
4. Ayrard P., Orehek J., Grimaud C., and Charpin. Bronchoconstrictor effect of a deep inspiration in patients with asthma. Am Rev Respir Dis 111 (1975) 433-439
5. Fish J., Ankin M., Kelly J., and Peterman V. Regulation of bronchomotor tone by lung inflation in asthmatic and non-asthmatic subjects. J Appl Physiol Respir Environ Exercise Physiol 50 (1981) 1079-1086
6. Nadel J., and Tierney D. Effect of a previous deep inspiration on airways resistance in man. J Appl Physiol 16 (1961) 717-719
7. Pellegrino R., Violante B., Crimi E., and Brusasco V. Effects of deep inhalation during early and late asthmatic reactions to allergen. Am Rev Respir Dis 142 (1990) 822-825
8. Scichilone N., Permutt S., and Togias A. The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness. Am J Respir Crit Care Med 163 (2001) 413-419
9. Skloot G., Solbert P., and Togias A.J. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. Clin Invest 96 5 (1995) 2393-2403
10. Kapsali T., Permutt S., Laube B., Scichilone N., and Togias A. Potent bronchoprotective effect of deep inspiration and its absence in asthma. J Appl Physiol 89 (2000) 711-720
11. Amato M., Barbas C., Medeiros D., Magaldi R., Schettino G., Lorenzi-Filho G., et al. Effect of a protective lung strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338 (1998) 347-354
12. Network A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342 (2000) 1301-1308
13. Tremblay L., Valenza F., Ribeiro S., Li J., and Slutsky A. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 99 (1997) 944-952
14. Nepomuk von Bethmann A., Brasch F., Nüsing R., Vogt K., Volk H., et al. Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med 157 (1998) 263-272
15. Chiumello D., Pristine G., and Slutsky A. Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 160 (1999) 109-116
16. Nakamura T., Malloy J., McCaig L., et al. Mechanical ventilation of isolated septic rat lungs: effects on surfactant and inflammatory cytokines. J Appl Physiol 91 (2001) 811-820
17. Meduri G., Headley S., Kohler G., Stentz F., Tolley E., et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Chest 107 (1995) 1062-1072
18. Vlahakis N., Schroeder M., Limper A., and Hubmayer R. Stretch induces cytokine release by alveolar epithelial cells in vitro. Am J Physiol 277 (1999) L167-L173
19. Yamamoto H., Teramoto H., Uetani K., Igawa K., and Shimizu E. Cyclic stretch upregulates interleukin-8 and transforming growth factor-ß1 production through a protein kinase C-dependent pathway in alveolar cells. Respirology 7 (2002) 103-109
20. Oudin S., and Pugin J. Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 27 (2002) 107-114
21. Wang A., Yokosaki Y., Ferrando R., Balmes J., and Sheppard D. Differential regulation of airway epithelial integrins by growth factors. Am J Respir Cell Mol Biol 15 (1996) 664-672
22. Sheppard D. Airway epithelial integrins: why so many?. Am J Respir Cell Mol Biol 19 (1998) 349-351
23. Hynes. Integrins, a family of cell surface receptors. Cell 48 (1987) 549-555
24. Sai X., Naruse K., and Sokabe M. Activation of p60src is critical for stretch-induced orienting response in fibroblasts. J Cell Sci 112 (1999) 1365-1373
25. Correa-Meyer E., Pesce L., Guerrero C., and Sznajder J.I. Mechanotransduction in the lung: cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 282 (2002) 883-891
26. Reddel R., Ke Y., Gerwin B., McMenamin M., Lechner J., Su R., et al. Transformation of human bronchial epithelial cells by infection with SV40 or Adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate co-precipitation with a plasmid containing SV40 early region genes. Cancer Res 48 (1988) 1904-1909
27. Atsuta J., Sterbinsky S., Plitt J., Schwiebert L., Bochner B., and RP S. Phenotyping and cytokine regulation of the BEAS-2B human bronchial epithelial cell: demonstration of inducible expression of the adhesion molecules VCAM-1 and ICAM-1. Am J Respir Cell Mol Biol 17 (1997) 571-582
28. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., et al. Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases. Mol Pharmacol 57 (2000) 976-983
29. Savla U., Sporn P., and Waters C. Cyclic stretch of airway epithelium inhibits prostanoid synthesis. Am J Physiol 273 (1997) L1013-L1019
30. Reynauld J.-C. New Insights into the role of cytokines in asthma. J Clin Pathol 54 (2001) 577-589
31. McLean A. Regulation with RANTES. Lancet 343 (1994) 189-190
32. Leff A.R. Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways. Am J Respir Crit Care Med 161 (2000) S125-S132
33. Wirtz H., and Dobbs L. The effects of mechanical forces on lung functions. Respir Physiol 119 (2000) 1-17
34. Tschumperlin D., and Margulies S.S. Alveolar epithelial surface area-volume relationship in isolated rat lungs. J Appl Physiol 86 (1999) 2026-2033
35. Bachofen H., Schurch M., Urbinelli M., and Weibel E. Relations among alveolar surface tension, surface area, volume and recoil pressure. J Appl Physiol 62 (1987) 1878-1887
36. Tschumperlin D., and Margulies S. Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. Lung Cell Mol Physiol 19 (1998) L1173-L1183
37. Madaule P., et al. A novel Ras-related gene family. Cell 41 (1985) 31-40
38. Ridley A. Rho family proteins: coordinating cell responses. Trends Cell Biol 11 (2001) 471-477
39. Leung T., Chen X., Manser E., and Lim L. The p160 RhoA-binding kinase ROK a is a member of a kinase family and is involved in the reorganisation of the cytoskeleton. Mol Cell Biol 16 (1996) 5313-5327
40. Schwartz M., and Shattil S. Signalling networks linking integrins and Rho family GTPases. Trends Biochem Sci 25 (2000) 388-391
41. Koksel O., Yildirim C., Tiftik R.N., Kubat H., Tamer L., Cinel L., et al. Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. Eur J Pharmacol 510 (2005) 135-142