Antigenotoxic action of isothiocyanate-containing mustard as determined by two cancer biomarkers in a human intervention trial

European Journal of Cancer Prevention

Volumn 21, Issue 4, 2012, Pages 400-406

  Lamy, Evelyn ^a   Garcia Käufer, Manuel ^a   Prinzhorn, Julia ^b   Mersch Sundermann, Volker ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES OSNABRÜCK   (Germany)

Author keywords

antigenotoxicity; human intervention trial; isothiocyanate; mustard

Indexed keywords

BENZO[A]PYRENE; CHOLESTEROL; HYDROGEN PEROXIDE; ISOTHIOCYANIC ACID; TUMOR MARKER;

ADULT; ARTICLE; CHEMOPROPHYLAXIS; CHOLESTEROL BLOOD LEVEL; COMET ASSAY; DNA DAMAGE; DRUG MECHANISM; FEMALE; GENOTOXICITY; HEPARINIZATION; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MUSTARD; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VEIN PUNCTURE;

ADULT; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOMARKERS, PHARMACOLOGICAL; CHEMOPREVENTION; DIET; DNA DAMAGE; FEMALE; HUMANS; ISOTHIOCYANATES; MALE; MICRONUCLEUS TESTS; MUSTARD PLANT; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84861795057     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e32834ef140     Document Type: Article

References (33)

1. Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, et al. (2007). An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28:625-631.
2. Clare MG, Lorenzon G, Akhurst LC, Marzin D, Van Delft J, Montero R, et al. (2006). SFTG international collaborative study on in-vitro micronucleus test II. Using human lymphocytes. Mutat Res 607:37-60.
3. Conaway CC, Yang YM, Chung FL (2002). Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 3:233-255.
4. Duthie SJ, Jenkinson AM, Crozier A, Mullen W, Pirie L, Kyle J, et al. (2006). The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur J Nutr 45:113-122.
5. Fenech M (2007). Cytokinesis-block micronucleus cytome assay. Nat Protoc 2:1084-1104.
6. Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E (2003). HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res 534:65-75.
7. Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN (1989). Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood 73:334-339.
8. Gill CIH, Haldar S, Porter S, Matthews S, Sullivan S, Coulter J, et al. (2004). The effect of cruciferous and leguminous sprouts on genotoxicity, in vitro and in vivo. Cancer Epidemiol Biomarkers Prev 13:1199-1205.
9. Gill CIR, Haldar S, Boyd LA, Bennett R, Whiteford J, Butler M, et al. (2007). Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. Am J Clin Nutr 85: 504-510.
10. Halliwell B, Gutteridge JM (1990). Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1-85.
11. Hoelzl C, Glatt H, Meinl W, Sontag G, Haidinger G, Kundi M, et al. (2008). Consumption of brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxida-tive DNA-damage: results of a controlled human intervention trial. Mol Nutr Food Res 52:330-341.
12. Kehrer JP (2000). The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 149:43-50.
13. Lamy E, Schröder J, Paulus S, Brenk P, Stahl T, Mersch-Sundermann V (2008). Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action. Food Chem Toxicol 46:2415-2421.
14. Lamy E, Scholtes C, Herz C, Mersch-Sundermann V (2011a). Pharmacokinetics and pharmacodynamics of isothiocyanates. Drug Metab Rev 43:387-407.
15. Lamy E, Schmitz S, Krumbein A, Mersch-Sundermann V (2011b). Isothiocyanate-containing mustard protects human cells against genotoxins in vitro and in vivo. Mutat Res 726:146-150.
16. Lieberman HB (2008). DNA damage repair and response proteins as targets for cancer therapy. Curr Med Chem 15:360-367.
17. Liptrott NJ, Penny M, Bray PG, Sathish J, Khoo SH, Back DJ, et al. (2009). The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharmacol 156:497-508.
18. Loft S, Poulsen HE (1996). Cancer risk and oxidative DNA damage in man. J Mol Med 74:297-312.
19. Moller P, Loft S (2002). Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies. Am J Clin Nutr 76:303-310.
20. Moller P, Knudsen LE, Loft S, Wallin H (2000). The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9:1005-1015.
21. Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A (2004). Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Biofactors 22:271-275.
22. Nanjee MN,Verhagen H,Van Poppel G, Rompelberg CJM,Van Bladeren PJ, Miller NE (1996). Do dietary phytochemicals with cytochrome P-450 enzyme-inducing activity increase high-density-lipoprotein concentrations in humans? Am J Clin Nutr 64:706-711.
23. Riso P, Pinder A, Santangelo A, Porrini M (1999). Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Am J Clin Nutr 69:712-718.
24. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P (1998). Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev 7:1091-1100.
25. Stahl T, Haider G, Mersch-Sundermann V, Gminski R (2009). Chemopreventive acting components in mustard and mustard-derived products. Ernährung- sUmschau 4:208-215.
26. Steinkellner H, Hoelzl C, Uhl M, Cavin C, Haidinger G, Gsur A, et al. (2005). Coffee consumption induces GSTP in plasma and protects lymphocytes against (±)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials. Mutat Res 591:264-275.
27. Tang D, Phillips DH, Stampfer M, Mooney LA, Hsu Y, Cho S, et al. (2001). Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the Physicians Health Study. Cancer Res 61:6708-6712.
28. Van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA (1999). Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol 472:159-168.
29. Vermeulen M, Van den Berg R, Freidig AP, Van Bladeren PJ, Vaes WHJ (2006). Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids. J Agric Food Chem 54:5350-5358.
30. Vral A, Verhaegen F, Thierens H, de Ridder L (1994). The in-vitro cytokinesis-block micronucleus assay: a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis 9:439-443.
31. Weisel T, Baum M, Eisenbrand G, Dietrich H, Will F, Stockis JP, et al. (2006). An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J 1:388-397.
32. Wilms LC, Hollman PCH, Boots AW, Kleinjans JCS (2005). Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 582:155-162.
33. Zhang Y (2010). Allyl isothiocyanate as a cancer chemopreventive phytochem-ical. Mol Nutr Food Res 54:127-135.