The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC

British Journal of Pharmacology

Volumn 156, Issue 3, 2009, Pages 497-508

  Liptrott, N J ^a   Penny, M ^c   Bray, P G ^b   Sathish, J ^a   Khoo, S H ^a   Back, D J ^a   Owen, A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

ABCB1 (P glycoprotein); ABCC1 (MRP1); ABCC2 (MRP2); CCR5; CXCR4; CYP2B6; CYP3A4; Cytokines; Multidrug resistance; Peripheral blood mononuclear cell

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER C1; ABC TRANSPORTER C2; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; CYTOKINE; DIGOXIN; GAMMA INTERFERON; INTERLEUKIN 2; MESSENGER RNA; SAQUINAVIR; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; N DEMETHYLASE; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACCUMULATION; DRUG TRANSPORT; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL;

ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOKINES; DIGOXIN; FLOW CYTOMETRY; HUMANS; LEUKOCYTES, MONONUCLEAR; OXIDOREDUCTASES, N-DEMETHYLATING; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SAQUINAVIR;

EID: 65449131231     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00050.x     Document Type: Article

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