-
1
-
-
7044238416
-
Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs
-
DOI 10.1038/nm1113
-
Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 2004; 10:1055-63. (Pubitemid 39424865)
-
(2004)
Nature Medicine
, vol.10
, Issue.10
, pp. 1055-1063
-
-
Forman, M.S.1
Trojanowski, J.Q.2
Lee, V.M.-Y.3
-
2
-
-
33750361540
-
A century-old debate on protein aggregation and neurodegeneration enters the clinic
-
DOI 10.1038/nature05290, PII NATURE05290
-
Lansbury PT, Lashuel HA. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 2006; 443:774-9. (Pubitemid 44622681)
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 774-779
-
-
Lansbury, P.T.1
Lashuel, H.A.2
-
3
-
-
0035834076
-
beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
-
DOI 10.1073/pnas.211412398
-
Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, et al. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci USA 2001; 98:12245-50. (Pubitemid 32959858)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.21
, pp. 12245-12250
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Sagara, Y.4
Mallory, M.5
Hashimoto, M.6
Mucke, L.7
-
4
-
-
52349111812
-
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
-
Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, et al. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One 2008; 3:3135.
-
(2008)
PLoS One
, vol.3
, pp. 3135
-
-
Tsigelny, I.F.1
Crews, L.2
Desplats, P.3
Shaked, G.M.4
Sharikov, Y.5
Mizuno, H.6
-
5
-
-
56349119351
-
Linking Abeta and tau in late-onset Alzheimer's disease: A dual pathway hypothesis
-
Small SA, Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008; 60:534-42.
-
(2008)
Neuron
, vol.60
, pp. 534-542
-
-
Small, S.A.1
Duff, K.2
-
6
-
-
78651068014
-
Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, alpha synuclein and Abeta pathology
-
Head MW, Lowrie S, Chohan G, Knight R, Scoones DJ, Ironside JW. Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, alpha synuclein and Abeta pathology. Acta Neuropathol 2010; 120:821-3.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 821-823
-
-
Head, M.W.1
Lowrie, S.2
Chohan, G.3
Knight, R.4
Scoones, D.J.5
Ironside, J.W.6
-
7
-
-
0030908095
-
Models of amyloid seeding in Alzheimer's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins
-
DOI 10.1146/annurev.biochem.66.1.385
-
Harper JD, Lansbury PT Jr. Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem 1997; 66:385-407. (Pubitemid 27274662)
-
(1997)
Annual Review of Biochemistry
, vol.66
, pp. 385-407
-
-
Harper, J.D.1
Lansbury Jr., P.T.2
-
8
-
-
0037466656
-
Initiation and synergistic fibrillization of tau and alpha-synuctein
-
DOI 10.1126/science.1082324
-
Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300:636-40. (Pubitemid 36520587)
-
(2003)
Science
, vol.300
, Issue.5619
, pp. 636-640
-
-
Giasson, B.I.1
Forman, M.S.2
Higuchi, M.3
Golbe, L.I.4
Graves, C.L.5
Kotzbauer, P.T.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
-
9
-
-
0030004466
-
Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders
-
Schmidt ML, Martin JA, Lee VM, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathol 1996; 91:475-81.
-
(1996)
Acta Neuropathol
, vol.91
, pp. 475-481
-
-
Schmidt, M.L.1
Martin, J.A.2
Lee, V.M.3
Trojanowski, J.Q.4
-
10
-
-
0034653871
-
Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease
-
DOI 10.1016/S0022-510X(99)00327-5, PII S0022510X99003275
-
Marui W, Iseki E, Ueda K, Kosaka K. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. J Neurol Sci 2000; 174:81-4. (Pubitemid 30155896)
-
(2000)
Journal of the Neurological Sciences
, vol.174
, Issue.2
, pp. 81-84
-
-
Marui, W.1
Iseki, E.2
Ueda, K.3
Kosaka, K.4
-
11
-
-
77950633906
-
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases
-
Morales R, Estrada LD, Diaz-Espinoza R, Morales-Scheihing D, Jara MC, Castilla J, et al. Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases. J Neurosci 2010; 30:4528-35.
-
(2010)
J Neurosci
, vol.30
, pp. 4528-4535
-
-
Morales, R.1
Estrada, L.D.2
Diaz-Espinoza, R.3
Morales-Scheihing, D.4
Jara, M.C.5
Castilla, J.6
-
12
-
-
70349705441
-
Prions: Protein aggregation and infectious diseases
-
Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009; 89:1105-52.
-
(2009)
Physiol Rev
, vol.89
, pp. 1105-1152
-
-
Aguzzi, A.1
Calella, A.M.2
-
13
-
-
0020321767
-
Novel proteinaceous infectious particles cause scrapie
-
Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-44. (Pubitemid 12089840)
-
(1982)
Science
, vol.216
, Issue.4542
, pp. 136-144
-
-
Prusiner, S.B.1
-
14
-
-
0028861588
-
Neuropathology and the scrapie-kuru connection
-
Hadlow WJ. Neuropathology and the scrapie-kuru connection. Brain Pathol 1995; 5:27-31.
-
(1995)
Brain Pathol
, vol.5
, pp. 27-31
-
-
Hadlow, W.J.1
-
15
-
-
0036415838
-
Alpha-synuclein, especially the parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
-
DOI 10.1016/S0022-2836(02)00735-0
-
Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, et al. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 2002; 322:1089-102. (Pubitemid 35266514)
-
(2002)
Journal of Molecular Biology
, vol.322
, Issue.5
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
Simon, M.4
Nowak, R.J.5
Walz, T.6
Lansbury, J.P.T.7
-
16
-
-
79952742454
-
In vivo demonstration that alphasynuclein oligomers are toxic
-
Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, et al. In vivo demonstration that alphasynuclein oligomers are toxic. Proc Natl Acad Sci USA 2011; 108:4194-9.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 4194-4199
-
-
Winner, B.1
Jappelli, R.2
Maji, S.K.3
Desplats, P.A.4
Boyer, L.5
Aigner, S.6
-
17
-
-
69149089854
-
Inclusion formation and neurona cell death through neuron-to-neuron transmission of alpha-synuclein
-
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, et al. Inclusion formation and neurona cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 2009; 106:13010-5.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
-
18
-
-
77950571596
-
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
-
Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, et al. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 2010; 285:9262-72.
-
(2010)
J Biol Chem
, vol.285
, pp. 9262-9272
-
-
Lee, H.J.1
Suk, J.E.2
Patrick, C.3
Bae, E.J.4
Cho, J.H.5
Rho, S.6
-
19
-
-
78649907008
-
Cell-to-cell transmission of non-prion protein aggregates
-
Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 2010; 6:702-6.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 702-706
-
-
Lee, S.J.1
Desplats, P.2
Sigurdson, C.3
Tsigelny, I.4
Masliah, E.5
-
20
-
-
0036938637
-
Alpha-synuclein-immunoreactive deposits in human and animal prion diseases
-
DOI 10.1007/s00401-001-0499-z
-
Haik S, Privat N, Adjou KT, Sazdovitch V, Dormont D, Duyckaerts C, et al. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases. Acta Neuropathol (Berl) 2002; 103:516-20. (Pubitemid 36075349)
-
(2002)
Acta Neuropathologica
, vol.103
, Issue.5
, pp. 516-520
-
-
Haik, S.1
Privat, N.2
Adjou, K.T.3
Sazdovitch, V.4
Dormont, D.5
Duyckaerts, C.6
Hauw, J.J.7
-
21
-
-
34447258199
-
Alpha-synuclein Accumulates in the Brain of Scrapie-affected Sheep and Goats
-
DOI 10.1016/j.jcpa.2007.03.007, PII S002199750700045X
-
Adjou KT, Allix S, Ouidja MO, Backer S, Couquet C, Cornuejols MJ, et al. Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats. J Comp Pathol 2007; 137:78-81. (Pubitemid 47044753)
-
(2007)
Journal of Comparative Pathology
, vol.137
, Issue.1
, pp. 78-81
-
-
Adjou, K.T.1
Allix, S.2
Ouidja, M.O.3
Backer, S.4
Couquet, C.5
Cornuejols, M.-J.6
Deslys, J.-P.7
Brugere, H.8
Brugere-Picoux, J.9
El-Hachimi, K.H.10
-
22
-
-
0033570367
-
Evidence of presynaptic location and function of the prion protein
-
Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, et al. Evidence of presynaptic location and function of the prion protein. J Neurosci 1999; 19:8866-75. (Pubitemid 30226708)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.20
, pp. 8866-8875
-
-
Herms, J.1
Tings, T.2
Gall, S.3
Madlung, A.4
Giese, A.5
Siebert, H.6
Peter, S.O.7
Windl, T.8
Brose, N.9
Kretzschmar, H.10
-
23
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995; 14:467-75.
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
De Silva, H.A.6
-
24
-
-
79955522862
-
Transmission of prion strains in a transgenic mouse model overexpressing human A53T mutated alpha-synuclein
-
Mougenot AL, Bencsik A, Nicot S, Vulin J, Morignat E, Verchere J, et al. Transmission of prion strains in a transgenic mouse model overexpressing human A53T mutated alpha-synuclein. J Neuropathol Exp Neurol 2011; 70:377-85.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 377-385
-
-
Mougenot, A.L.1
Bencsik, A.2
Nicot, S.3
Vulin, J.4
Morignat, E.5
Verchere, J.6
-
25
-
-
84872753945
-
"Preclinical" MSA in definite Creutzfeldt-Jakob disease
-
Rodriguez-Diehl R, Rey MJ, Gironell A, Martinez-Saez E, Ferrer I, Sanchez-Valle R, et al. "Preclinical" MSA in definite Creutzfeldt-Jakob disease. Neuropathology.
-
Neuropathology
-
-
Rodriguez-Diehl, R.1
Rey, M.J.2
Gironell, A.3
Martinez-Saez, E.4
Ferrer, I.5
Sanchez-Valle, R.6
-
26
-
-
77949887824
-
An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology
-
Yoshida H, Terada S, Ishizu H, Ikeda K, Hayabara T, Deguchi K, et al. An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology. Neuropathology 2010; 30:159-64.
-
(2010)
Neuropathology
, vol.30
, pp. 159-164
-
-
Yoshida, H.1
Terada, S.2
Ishizu, H.3
Ikeda, K.4
Hayabara, T.5
Deguchi, K.6
-
27
-
-
49849091894
-
Association between deposition of betaamyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease
-
Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M. Association between deposition of betaamyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease. Neurodegener Dis 2008; 5:347-54.
-
(2008)
Neurodegener Dis
, vol.5
, pp. 347-354
-
-
Debatin, L.1
Streffer, J.2
Geissen, M.3
Matschke, J.4
Aguzzi, A.5
Glatzel, M.6
-
28
-
-
0036605566
-
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
-
DOI 10.1002/jnr.10231
-
Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, et al. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002; 68:568-78. (Pubitemid 34575622)
-
(2002)
Journal of Neuroscience Research
, vol.68
, Issue.5
, pp. 568-578
-
-
Rockenstein, E.1
Mallory, M.2
Hashimoto, M.3
Song, D.4
Shults, C.W.5
Lang, I.6
Masliah, E.7
-
29
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
DOI 10.1038/3311
-
Conway KA, Harper JD, Lansbury PT. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 1998; 4:1318-20. (Pubitemid 28512115)
-
(1998)
Nature Medicine
, vol.4
, Issue.11
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
30
-
-
72749093518
-
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption
-
Lim Y, Kehm VM, Li C, Trojanowski JQ, Lee VM. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol 2009; 221:86-97.
-
(2009)
Exp Neurol
, vol.221
, pp. 86-97
-
-
Lim, Y.1
Kehm, V.M.2
Li, C.3
Trojanowski, J.Q.4
Lee, V.M.5
-
31
-
-
72749113927
-
Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease
-
Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, et al. Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience 2010; 165:662-74.
-
(2010)
Neuroscience
, vol.165
, pp. 662-674
-
-
Asuni, A.A.1
Hilton, K.2
Siskova, Z.3
Lunnon, K.4
Reynolds, R.5
Perry, V.H.6
-
32
-
-
0025239839
-
Unusual topogenic sequence directs prion protein biogenesis
-
Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science 1990; 248:226-9.
-
(1990)
Science
, vol.248
, pp. 226-229
-
-
Lopez, C.D.1
Yost, C.S.2
Prusiner, S.B.3
Myers, R.M.4
Lingappa, V.R.5
-
33
-
-
0032488777
-
A transmembrane form of the prion protein in neurodegenerative disease
-
DOI 10.1126/science.279.5352.827
-
Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, et al. A transmembrane form of the prion protein in neurodegenerative disease. Science 1998; 279:827-34. (Pubitemid 28106269)
-
(1998)
Science
, vol.279
, Issue.5352
, pp. 827-834
-
-
Hegde, R.S.1
Mastrianni, J.A.2
Scott, M.R.3
DeFea, K.A.4
Tremblay, P.5
Torchia, M.6
DeArmond, S.J.7
Prusiner, S.B.8
Lingappa, V.R.9
-
34
-
-
78649960228
-
ER stress response plays an important role in aggregation of alpha-synuclein
-
Jiang P, Gan M, Ebrahim AS, Lin WL, Melrose HL, Yen SH. ER stress response plays an important role in aggregation of alpha-synuclein. Mol Neurodegener 2010; 5:56.
-
(2010)
Mol Neurodegener
, vol.5
, pp. 56
-
-
Jiang, P.1
Gan, M.2
Ebrahim, A.S.3
Lin, W.L.4
Melrose, H.L.5
Yen, S.H.6
-
35
-
-
0036500554
-
Sc) into contiguous membranes
-
DOI 10.1093/emboj/21.5.1031
-
Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrPres (PrP(Sc)) into contiguous membranes. EMBO J 2002; 21:1031-40. (Pubitemid 34206176)
-
(2002)
EMBO Journal
, vol.21
, Issue.5
, pp. 1031-1040
-
-
Baron, G.S.1
Wehrly, K.2
Dorward, D.W.3
Chesebro, B.4
Caughey, B.5
-
36
-
-
3342951965
-
Lipid rafts mediate the synaptic localization of alpha-synuclein
-
DOI 10.1523/JNEUROSCI.1594-04.2004
-
Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 2004; 24:6715-23. (Pubitemid 38993891)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.30
, pp. 6715-6723
-
-
Fortin, D.L.1
Troyer, M.D.2
Nakamura, K.3
Kubo, S.-I.4
Anthony, M.D.5
Edwards, R.H.6
-
38
-
-
77957245642
-
Genetic mouse models of Parkinson's disease the state of the art
-
Magen I, Chesselet MF. Genetic mouse models of Parkinson's disease The state of the art. Prog Brain Res 2010; 184:53-87.
-
(2010)
Prog Brain Res
, vol.184
, pp. 53-87
-
-
Magen, I.1
Chesselet, M.F.2
-
39
-
-
57549096688
-
The POM monoclonals: A comprehensive set of antibodies to non-overlapping prion protein epitopes
-
Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, et al. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS ONE 2008; 3:3872.
-
(2008)
PLoS ONE
, vol.3
, pp. 3872
-
-
Polymenidou, M.1
Moos, R.2
Scott, M.3
Sigurdson, C.4
Shi, Y.Z.5
Yajima, B.6
|