Alpha-synuclein-immunoreactive deposits in human and animal prion diseases

Acta Neuropathologica

Volumn 103, Issue 5, 2002, Pages 516-520

  Haik S ^a   Privat, N ^a   Adjou, K T ^b   Sazdovitch, V ^a   Dormont, D ^b   Duyckaerts, C ^a   Hauw, J J ^a  

^a BICHAT HOSPITAL   (France)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

Aggregation; Chaperone; Creutzfeldt Jakob disease; Neurodegeneration; Prion

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PROTEIN; ISOPROTEIN; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; FEMALE; HAMSTER; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SCRAPIE;

ALPHA-SYNUCLEIN; ANIMALS; CENTRAL NERVOUS SYSTEM; CREUTZFELDT-JAKOB SYNDROME; CRICETINAE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; NERVE TISSUE PROTEINS; NEURONS; NEUROPIL; PRIONS; PRPSC PROTEINS; SCRAPIE; SYNUCLEINS;

EID: 0036938637     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-001-0499-z     Document Type: Article

References (20)

1. Adjou T, Privat N, Demart S, Deslys J, Seman M, Hauw JJ, Dormont D (2000) MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters. J Comp Pathol 122:3-8
2. Billette de Villemeur T, Gelot A, Deslys JP, Dormont D, Duyckaerts C, Jardin L, Denni J, Robain O (1994) Iatrogenic Creutzfeldt-Jakob disease in three growth hormone recipients: a neuropathological study. Neuropathol Appl Neurobiol 20: 111-117
3. Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Jellinger K, Kretzschmar HA, Lantos PL, Masullo C, Schlote W, Tateishi J, Weller RO (1995) Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (Prion diseases). Brain Pathol 5:459-466
4. Charles V, Mezey E, Reddy PH, Dehejia A, Young TA, Polymeropoulos MH, Brownstein MJ, Tagle DA (2000) Alphasynuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models. Neurosci Lett 289:29-32
5. Conway KA, Harper JD, Lansbury PT Jr (2000) Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39:2552-2563
6. Culvenor JG, McLean CA, Cutt S, Campbell BC, Maher F, Jakala P, Hartmann T, Beyreuther K, Masters CL, Li QX (1999) Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited NAC and alpha-synuclein are not associated with AP amyloid. Am J Pathol 155:1173-1181
7. Debburman SK, Raymond GJ, Caughey B, Lindquist S (1997) Chaperone-supervised conversion of prion protein to its protease-resistant form. Proc Natl Acad Sci USA 94:13938-13943
8. Forloni G, Bertani I, Calella AM, Thaler F, Invernizzi R (2000) Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Ann Neurol 47:632-640
9. Hauw A Sazdovitch V, Laplanche JL, Peoc'h K, Kopp N, Kemeny J, Privat N, Delasnerie-Laupretre N, Brandel JP, Deslys JP, Dormont D, Alperovitch A (2000) Neuropathologic variants of sporadic Creutzfeldt-Jakob disease and codon 129 of PrP gene. Neurology 54:1641-1646
10. Ironside JW, Mccardle L, Hayward PA, Bell JE (1993) Ubiquitin immunocytochemistry in human spongiform encephalopathies. Neuropathol Appl Neurobiol 19:134-140
11. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, Silva HA de, Kittel A, Saitoh T (1995) The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14:467-475
12. McGowan DP, Roon-Mom W van, Holloway H, Bates GP, Mangiarini L, Cooper GJ, Faull RL, Snell RG (2000) Amyloid like inclusions in Huntington's disease. Neuroscience 100: 677-680
13. Prusiner SB (1998) Prions. Proc Natl Acad Sci USA 95: 13363-13383
14. Souza JM, Giasson BI, Lee VM, Ischiropoulos H (2000) Chaperone-like activity of synucleins. FEBS Lett 474:116-119
15. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R. Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388:839-840
16. Suenaga T, Hirano A. Llena J.F, Ksiezak-Reding H, Yen S-H, Dickson DW (1990) Ubiquitin immunoreactivity in Kuru plaques in Creutzfeldt-Jakob Disease. Ann Neurol 28:174-177
17. Telling GC, Scott M, Mastrianni J, Gabizon R, Torchia M, Cohen FE, DeArmond SJ, Prusiner SB (1995) Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell 83:79-90
18. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A, Poser S, Pocchiari M, Hofman A, Smith PG (1996) A new variant of Creutfeldt-Jakob disease in the UK. Lancet 347:921-925
19. Yoshimoto M, Iwai A, Kang D, Otero DA, Xia Y, Saitoh T (1995) NACP, the precursor protein of the non-amyloid beta/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ and stimulates Aβ aggregation. Proc Natl Acad Sci USA 92:9141-9145
20. Zhou W, Hurlbert MS, Schaack J, Prasad KN, Freed CR (2000) Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Res 866:33-43