ER stress response plays an important role in aggregation of -synuclein

Molecular Neurodegeneration

Volumn 5, Issue 1, 2010, Pages

  Jiang, Peizhou ^a   Gan, Ming ^a   Ebrahim, Abdul Shukkur ^a   Lin, Wen Lang ^a   Melrose, Heather L ^a   Yen, Shu Hui C ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALPHA SYNUCLEIN; BUTYRIC ACID; CASPASE 3; CASPASE 9; CYCLOHEXIMIDE; HISTONE DEACETYLASE INHIBITOR; OLIGOMER; SALUBRINAL; TUNICAMYCIN; VALPROIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEWY BODY; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; WILD TYPE;

MUS MUSCULUS;

EID: 78649960228     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-5-56     Document Type: Article

References (64)

1. The biochemistry of Parkinson's disease. MR Cookson, Annu Rev Biochem 2005 74 29 52 10.1146/annurev.biochem.74.082803.133400 15952880
2. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. CF Lippa JE Duda M Grossman HI Hurtig D Aarsland BF Boeve DJ Brooks DW Dickson B Dubois M Emre S Fahn JM Farmer D Galasko JE Galvin CG Goetz JH Growdon KA Gwinn-Hardy J Hardy P Heutink T Iwatsubo K Kosaka VM Lee JB Leverenz E Masliah IG McKeith RL Nussbaum CW Olanow BM Ravina AB Singleton CM Tanner JQ Trojanowski ZK Wszolek, Neurology 2007 68 812 819 10.1212/01.wnl. 0000256715.13907.d3 17353469
3. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. MC Chartier-Harlin J Kachergus C Roumier V Mouroux X Douay S Lincoln C Levecque L Larvor, Lancet 2004 364 1167 1169 10.1016/S0140-6736(04)17103-1 15451224
4. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. P Ib̃ez AM Bonnet B Débarges E Lohmann F Tison P Pollak Y Agid A Dürr A Brice, Lancet 2004 364 1169 1171 15451225
5. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. R Krüger W Kuhn T Müller D Woitalla M Graeber S Kösel H Przuntek, Nat Genet 1998 18 106 108 9462735
6. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. MH Polymeropoulos C Lavedan E Leroy SE Ide A Dehejia A Dutra B Pike, Science 1997 276 2045 2047 10.1126/science.276.5321.2045 9197268
7. Alpha-Synuclein locus triplication causes Parkinson's disease. AB Singleton M Farrer J Johnson A Singleton S Hague J Kachergus M Hulihan T Peuralinna A Dutra R Nussbaum S Lincoln, Science 2003 302 841 10.1126/science.1090278 14593171
8. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. JJ Zarranz J Alegre JC Gámez-Esteban E Lezcano R Ros I Ampuero L Vidal J Hoenicka, Ann Neurol 2004 55 164 173 10.1002/ana.10795 14755719
9. Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death. H Jiang YC Wu M Nakamura Y Liang Y Tanaka S Holmes VL Dawson TM Dawson CA Ross WW Smith, Neurobiol Aging 2007 28 1709 1717 10.1016/j.neurobiolaging.2006.07.017 16978743
10. Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. WH Yu Y Matsuoka I Szirki A Hashim J Lafrancois H Sershen KE Duff, Neurochem Res 2008 33 902 911 10.1007/s11064-007-9533-4 17999181
11. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. TF Outeiro E Kontopoulos SM Altmann I Kufareva KE Strathearn AM Amore CB Volk MM Maxwell JC Rochet PJ McLean, Science 2007 317 516 519 10.1126/science.1143780 17588900
12. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. E Kontopoulos JD Parvin MB Feany, Hum Mol Genet 2006 15 3012 3023 10.1093/hmg/ddl243 16959795
13. Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D. M Takahashi LW Ko J Kulathingal P Jiang D Sevlever SH Yen, Eur J Neurosci 2007 26 863 874 10.1111/j.1460-9568.2007.05736.x 17714183
14. Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. LW Ko HH Ko WL Lin JG Kulathingal SH Yen, J Neuropathol Exp Neurol 2008 67 1084 1096 10.1097/NEN.0b013e31818c3618 18957893
15. Histone acetyltransferase complexes: one size doesn't fit all. KK Lee JL Workman, Nat Rev Mol Cell Biol 2007 8 284 295 10.1038/nrm2145 17380162
16. Chromatin modifications and their function. T Kouzarides, Cell 2007 128 693 705 10.1016/j.cell.2007.02.005 17320507
17. Histone deacetylase inhibitors: gathering pace. N Carey NB La Thangue, Curr Opin Pharmacol 2006 6 369 375 10.1016/j.coph.2006.03.010 16781195
18. Histone deacetylase inhibitors open new doors in cancer therapy. F McLaughlin NB La Thangue, Biochem Pharmacol 2004 68 1139 1144 10.1016/j.bcp.2004.05.034 15313411
19. Histone deacetylases (HDACs): characterization of the classical HDAC family. AJ de Ruijter AH van Gennip HN Caron S Kemp AB van Kuilenburg, Biochem J 2003 370 737 749 10.1042/BJ20021321 12429021
20. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. J Taunton CA Hassig SL Schreiber, Science 1996 272 408 411 10.1126/science.272.5260.408 8602529
21. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. SE Rundlett AA Carmen R Kobayashi S Bavykin BM Turner M Grunstein, Proc Natl Acad Sci USA 1996 93 14503 14508 10.1073/pnas.93.25.14503 8962081
22. Inhibition of histone deacetylase1 induces autophagy. M Oh IK Choi HJ Kwon, Biochem Biophys Res Commun 2008 369 1179 83 10.1016/j.bbrc.2008.03.019 18342621
23. Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. AL Boutillier E Trinh JP Loeffler, J Neurochem 2003 84 814 828 10.1046/j.1471-4159.2003.01581.x 12562525
24. Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. J Hofmanov A Vaculov A Lojek A Kozubík, Eur J Nutr 2005 44 40 51 15309463 (Pubitemid 40254234)
25. The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress. M Louis RR Rosato L Brault S Osbild E Battaglia XH Yang S Grant D Bagrel, Int J Oncol 2004 25 1701 1711 15547708
26. Effect of sodium butyrate on reactive oxygen species generation by human neutrophils. Q Liu T Shimoyama K Suzuki T Umeda S Nakaji K Sugawara, Scand J Gastroenterol 2001 36 744 50 10.1080/003655201300192012 11444474
27. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. C Giardina H Boulares MS Inan, Biochim Biophys Acta 1999 1448 425 438 10.1016/S0167-4889(98) 00156-6 9990295
28. Evidence of a functional role for the cyclin-dependent kinase-inhibitor p21WAF1/CIP1/MDA6 in promoting differentiation and preventing mitochondrial dysfunction and apoptosis induced by sodium butyrate in human myelomonocytic leukemia cells (U937). RR Rosato Z Wang RV Gopalkrishnan PB Fisher S Grant, Int J Oncol 2001 19 181 191 11408941
29. Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/caspase pathway, associated with degradation of beta-catenin, pRb and Bcl-XL. S Emanuele A D'Anneo G Bellavia B Vassallo M Lauricella A De Blasio R Vento G Tesoriere, Eur J Cancer 2004 40 1441 1452 10.1016/j.ejca.2004.01.039 15177505
30. Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetypase inhibitor-induced apoptosis. P Baueister D Dong Y Fu AS Lee, Mol Cancer Ther 2009 8 1086 1093 10.1158/1535-7163.MCT-08- 1166
31. Enhancement of cisplatin cytotoxicity by SAHA involved endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells. M Suzuki M Endo F Shinohara S Echigo H Rikiishi, Cancer Chemother Pharmacol 2009 64 1115 1122 10.1007/s00280-009-0969-x 19280190
32. Treatment with panobionstat induces glucose-regulated protein 78 acetylation and endoplamic reticulum stress in breast cancer cells. R Rao S Nalluri R Kolhe Y Yang W Fiskus J Chen K Ha KM Buckley R Balusu V Coothankandaswamy A Joshi P Atadja KN Bhalla, Mol Cancer Ther 2010 9 942 952 10.1158/1535-7163.MCT-09-0988 20371724
33. Comparison of melatonin versus vitamin C on oxidative stress and antioxidant enzyme activity in Alzheimer's disease induced by okadaic acid in neuroblastoma cells. P Montilla-Lápez MC Mũoz-Agueda M Feijáo Lápez JR Mũoz-Castãeda I Bujalance-Arenas I Tnez-Fĩana, Eur J Pharmacol 2002 451 237 243 12242084
34. Membrane fatty acids, lipid peroxidation and adenylate cyclase activity in cultured neural cells. MG Murphy, Biochem Biophys Res Commun 1985 132 757 763 10.1016/0006-291X(85)91197-0 2998383
35. Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells. N André D Braguer G Brasseur A Gonçalves D Lemesle-Meunier S Guise MA Jordan C Briand, Cancer Res 2000 60 5349 5353 11034069
36. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. M Boyce KF Bryant C Jousse K Long HP Harding D Scheuner RJ Kaufman D Ma DM Coen D Ron J Yuan, Science 2005 307 935 939 10.1126/science.1101902 15705855
37. Activation of PERK signaling attenuates Abeta-mediated ER stress. Y Lee do KS Lee HJ Lee H Kim do YH Noh K Yu HY Jung SH Lee JY Lee YC Youn Y Jeong DK Kim WB Lee SS Kim, PLoS One 2010 5 10489 10.1371/journal.pone.0010489 20463975
38. Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells. HO Pae SO Jeong GS Jeong KM Kim HS Kim SA Kim YC Kim SD Kang BN Kim HT Chung, Biochem Biophys Res Commun 2007 353 1040 1045 10.1016/j.bbrc.2006.12.133 17198682
39. Eif-2a protects brainstem motoneurons in a murine model of sleep apnea. Y Zhu P Fenik G Zhan B Sanfillipo-Cohn N Naidoo SC Veasey, J Neurosci 2008 28 2168 2178 10.1523/JNEUROSCI.5232-07.2008 18305250
40. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. WW Smith H Jiang Z Pei Y Tanaka H Morita A Sawa VL Dawson TM Dawson CA Ross, Hum Mol Genet 2005 14 3801 3811 10.1093/hmg/ddi396 16239241
41. Enhanced signaling dowstream of ribonucleic acid-activated protein kinase-like endoplasmic reticulm kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. L Ladriere M Igoillo-Esteve DA Cunha JP Brion M Bugliani P Marchetti DL Eizirik M Conp, J Clin Endocrinol Metab 2010 95 1442 1449 10.1210/jc.2009-2322 20080856
42. Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. AS Hillmer P Putcha J Levin T Högen BT Hyman H Kretzschmar PJ McLean A Giese, Biochem Biophys Res Commun 2010 391 461 466 10.1016/j.bbrc.2009.11.080 19914207
43. Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. P Putcha KM Danzer LR Kranich A Scott M Silinski S Mabbett CD Hicks JM Veal PM Steed BT Hyman PJ McLean, J Pharmacol Exp Ther 2010 332 849 857 10.1124/jpet.109.158436 19934398
44. Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. N Sugeno A Takeda T Hasegawa M Kobayashi A Kikuchi F Mori K Wakabayashi Y Itoyama, J Biol Chem 2008 283 23179 88 10.1074/jbc.M802223200 18562315
45. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. AA Cooper AD Gitler A Cashikar CM Haynes KJ Hill B Bhullar K Liu K Xu KE Strathearn F Liu S Cao KA Caldwell GA Caldwell G Marsischky RD Kolodner J Labaer JC Rochet NM Bonini S Lindquist, Science 2006 313 324 328 10.1126/science.1129462 16794039
46. Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. S Ito K Nakaso K Imamura T Takeshima K Nakashima, Neurosci Res 2010 66 124 130 10.1016/j.neures.2009.10.005 19835916
47. Activation of the unfolded protein response in Parkinson's disease. JJ Hoozemans ES van Haastert P Eikelenboom RA de Vos JM Rozemuller W Scheper, Biochem Biophys Res Commun 2007 354 707 711 10.1016/j.bbrc.2007.01.043 17254549
48. Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons. WA Holtz KL O'Malley, J Biol Chem 2003 278 19367 19377 10.1074/jbc.M211821200 12598533
49. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. EJ Ryu HP Harding JM Angelastro OV Vitolo D Ron LA Greene, J Neurosci 2002 22 10690 10698 12486162
50. Reticulon RTN1-C(CT) peptide: a potential nuclease and inhibitor of histone deacetylase enzymes. R Nepravishta A Bellomaria F Polizio M Paci S Melino, Biochemistry 2010 49 252 258 10.1021/bi9012676 20000484
51. Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis. S Krishnan EY Chi SJ Wood BS Kendrick C Li W Garzon-Rodriguez J Wypych TW Randolph LO Narhi AL Biere M Citron JF Carpenter, Biochemistry 2003 42 829 837 10.1021/bi026528t 12534296
52. Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. PJ McLean H Kawamata BT Hyman, Neuroscience 2001 104 901 912 10.1016/S0306-4522(01)00113-0 11440819
53. Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. E Junn RD Ronchetti MM Quezado SY Kim MM Mouradian, Proc Natl Acad Sci USA 2003 100 2047 2052 10.1073/pnas.0438021100 12576551
54. Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein. I Brandt M Gérard K Sergeant B Devreese V Baekelandt K Augustyns S Scharpé Y Engelborghs AM Lambeir, Peptides 2008 29 1472 1478 10.1016/j.peptides.2008.05.005 18571285
55. Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. A Ryo T Togo T Nakai A Hirai M Nishi A Yamaguchi K Suzuki Y Hirayasu, J Biol Chem 2006 281 4117 4125 10.1074/jbc.M507026200 16365047
56. The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. M Gerard Z Debyser L Desender PJ Kahle J Baert V Baekelandt Y Engelborghs, FASEB J 2006 20 524 526 16410343
57. Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease. L Brighina A Prigione B Begni A Galbussera S Andreoni R Piolti C Ferrarese, Neurobiol Aging 2010 31 884 885 10.1016/j.neurobiolaging.2008.06.010 18676060
58. Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. W Li C Lesuisse Y Xu JC Troncoso DL Price MK Lee, J Neurosci 2004 24 7400 7409 10.1523/JNEUROSCI.1370-04.2004 15317865
59. ER and aging-Protein folding and the ER stress response. N Naidoo, Ageing Res Rev 2009 8 150 159 10.1016/j.arr.2009.03.001 19491040
60. Histone deacetylase inhibitors: possible implications for neurodegenerative disorders. E Hahnen J Hauke C Tränkle IY Eyüpoglu B Wirth I Blümcke, Expert Opin Investig Drugs 2008 17 169 184 10.1517/13543784.17.2.169 18230051
61. Method for serum-free culture of late fetal and early postnatal rat brainstem neurons. BM Kivell FJ McDonald JH Miller, Brain Res Brain Res Protoc 2001 6 91 99 10.1016/S1385-299X(00)00037-4 11223407
62. Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. JW Touchman A Dehejia O Chiba-Falek DE Cabin JR Schwartz BM Orrison MH Polymeropoulos RL Nussbaum, Genome Res 2001 11 78 86 10.1101/gr.165801 11156617
63. Widespread alterations of alpha-synuclein in multiple system atrophy. DW Dickson W Liu J Hardy M Farrer N Mehta R Uitti M Mark T Zimmerman L Golbe J Sage A Sima C D'Amato R Albin S Gilman SH Yen, Am J Pathol 1999 155 1241 1251 10514406 (Pubitemid 29488931)
64. Using leucine zipper to facilitate alpha-synuclein assembly. P Jiang LW Ko KR Jansen TE Golde SH Yen, FASEB J 2008 22 3165 3174 10.1096/fj.08-108365 18492724