The viral enterprises in autoimmunity: Conversion of target cells into de novo APCs is the presage to autoimmunity

Autoimmunity Reviews

Volumn 11, Issue 9, 2012, Pages 653-658

  Temajo, Norbert O ^a,b   Howard, Neville ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b NONE   (Australia)

Author keywords

AIRE; Apoptosis; Autoimmunity; De novo APC; FOXP3; IE

Indexed keywords

HISTONE DEACETYLASE; IMMEDIATE EARLY PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELIAC DISEASE; GENE EXPRESSION; HAPLOTYPE; HUMAN; REVIEW; T LYMPHOCYTE; THYROID DISEASE; VIRUS REPLICATION;

EID: 84861748498     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.11.008     Document Type: Review

References (40)

1. C. Grossman, Z. Dovrish, Y. Shoenfeld, H. Amital, Do infections facilitate the emergence of systemic sclerosis? Autoimmun Rev. 2010 Sep 21. [Epub ahead of print].
2. Richer M.J., Horwitz M.S. Coxsackievirus infection as an environmental factor in the etiology of type 1 diabetes. Autoimmun Rev. 2009, 8(7):611-615.
3. Goldberg E., Krause I. Infection and type 1 diabetes mellitus - a two edged sword?. Autoimmun Rev. 2009, 8(8):682-686.
4. Sansonno L., Tucci F.A., Sansonno S., Lauletta G., Troiani L., Sansonno D. B cells and HCV: an infection model of autoimmunity. Autoimmun Rev. 2009, 9(2):93-94.
5. Aota N., Shiohara T. Viral connection between drug rashes and autoimmune diseases: how autoimmune responses are generated after resolution of drug rashes. Autoimmun Rev. 2009, 8(6):488-494.
6. Plot L., Amital H. Infectious associations of Celiac disease. Autoimmun Rev. 2009, 8(4):316-319.
7. Tang Q., Maul G.G. Mouse cytomegalovirus immediate-early protein 1 binds with host cell repressors to relieve suppressive effects on viral transcription and replication during lytic infection. J Virol. 2002, 77:1357-1367.
8. Miller D.L., Myers C.L., Rickards B., Coller H.A., Flint S.J. Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival. Genome Biol. 2007, 8:R58.
9. Nevels M., Paulus C., Shenk T. Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. PNAS 2004, 101:17234-17239.
10. Derbinski J., Gabler J., Brors B., Tierling S., Jonnakuty S., Hergenhahn M., et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp. Med. 2005, 202:33-45.
11. + medullary thymic epithelial cells. Nat. Immunol. 2007, 8:351-358.
12. Goodnow C.C., Sprent J., de St Groth B.F., Vinuesa C.G. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005, 435:590-597.
13. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Clin. Endocrinol. Metab. 2006, 91:2843-2850.
14. Peterson P., Peltonen L. Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity. J Auto Immunol. 2005, 25:S49-S55.
15. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101:455-458.
16. Baecher-Allan D.A. Hafler, human regulatory T cells and their role in autoimmune disease. Immunol Rev. 2006, 212:203-216.
17. Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27:18-20.
18. + regulatory T cells by antigen-presenting dendritic cells. J. Exp. Med. 2003, 198:235-247.
19. + regulatory T cells. Nat. Immunol. 2003, 4:330-336.
20. Marson A., Kretschmer K., Frampton G.M., Jacobsen E.S., Polansky J.K., Maclsaac K.D., et al. FOXP3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007, 445:931-935.
21. Reith W., Boss J.M. New dimensions to CIITA. Nat. Immunol. 2008, 9:713-714.
22. Wright K.L., Ting J.P. Epigenetic regulation of MHC-II and CIITA genes. Trends in Immunol. 2006, 27:405-412.
23. Ni Z., El Hassan M.A., Xu Z., Yu T., Bremner R. The chromatin-remodelling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers. Nat. Immunol. 2008, 9:785-793.
24. Majumder P., Gomez J.A., Chadwick B.P., Boss J.M. The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. JEM 2008, 205:785-798.
25. Smyth D.J., Plagnol V., Walker N.M., Cooper J.D., Downes K., Yang J.H.M., et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. Diabetes 2003, 53:3020-3023.
26. Todd J.A., Walker N.M., Cooper J.D., Smyth D., Downes K., Plagnol V., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics 2007, 39:857-864.
27. Morris A.C., Beresford G.W., Mooney M.R., Boss J.M. Kinetics of gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation. Mol. Cell. Biol. 2002, 22:4781-4791.
28. Masternak K., Muhlethaler-Mottet A., Villard J., Zufferey M., Steimle V., Reith W. CIITA is a transcriptional activator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 2000, 14:1156-1166.
29. Zika E., Greer S.F., Zhu X.S., Ting J.P.Y. Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol. Cell. Biol. 2003, 23:3091-3102.
30. Temajo N.O., Howard N. The co-operative specificity theory: phenotypic protection from T1D by certain HLA Class II DRB1 and DQ alleles identifies the absence of co-operation between the respective DR and DQ molecules eventuating in no T1D-predisposition. Autoimmun. Rev. 2009, 8:364-368.
31. Magner W.J., Kazim A.L., Stewart C., Romano M.A., Catalano G., Grande C., et al. Activation of MHC Class I, II, and CD40 gene expression by histone deacetylase inhibitors. J. Immunol. 2000, 165:7017-7024.
32. Ferenczy M.W., DeLuca N.A. Epigenetic modulation of gene expression from quiescent herpes simplex virus genomes. J. Virol. 2009, 83:8514-8524.
33. Jin L., Waterman P.M., Jonscher K.R., Short C.M., Reisdoeph N.A., Cambier J.C. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Molecular and Cellular Biology 2008, 28:5014-5026.
34. Drenou L., Amiot N., Setterbald S., Taque V., Guilloux D., Charron D., et al. MHC class II signalling function is regulated during maturation of plasmacytoid dendritic cells. Journal for Leukocyte Biology 2005, 77:560-567.
35. Al-Daccak R., Mooney N., Charron D. MHC class II signalling in antigen-presenting cells. Curr. Opin. Immunol. 2004, 16:108-113.
36. Blancheteau V., Charron D., Mooney N. HLA class II signals sensitize B lymphocytes to apoptosis via Fas/CD95 by increasing FADD recruitment to activated Fas and activation of caspases. Hum. Immunol. 2002, 63:375-383.
37. Setterbald N., Blancheteau V., Delaguillaumie A., Michel F., Becart S., Lombardi G., et al. Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. J. Leukoc. Biol. 2004, 75:1036-1044.
38. Ronchese F., Hermans I.F. Killing of dendritic cells: a life cut short or a purposeful death?. J. Exp. Med. 2001, 194:F23-F26.
39. Thilenius A.R.B., Sabelko-Downes K.A., Russell J.H. The role of the antigen-presenting cell in Fas-mediated direct and bystander killing: potential in vivo function of Fas in experimental allergic encephalomyelitis. J. Immunol. 1999, 162:643-650.
40. Humphreys-Beher M.G., Peck A.B., Dang H., Talal N. The role of apoptosis in the initiation of the autoimmune response in Sjogren's syndrome. Clin. Exp. Immunol. 1999, 116:383-387.