The Co-operative Specificity Theory: Phenotypic protection from T1D by certain HLA Class II DRB1 and DQ alleles identifies the absence of co-operation between the respective DR and DQ molecules eventuating in no T1D-predisposition

Autoimmunity Reviews

Volumn 8, Issue 5, 2009, Pages 364-368

  Temajo, Norbert O ^a   Howard, Neville ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Co operative specificity; Linkage disequilibrium; Predisposition; Protection; Susceptibility

Indexed keywords

AUTOANTIGEN; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ALLELE; CELL PROTECTION; COOPERATIVE SPECIFICITY THEORY; GENE; GENETIC PREDISPOSITION; HAPLOTYPE; HLA DQ GENE; HLA DR GENE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR RECOGNITION; PHENOTYPE; PROTEIN PROTEIN INTERACTION; REVIEW; THEORY VALIDATION;

ALLELES; ANIMALS; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; ISLETS OF LANGERHANS; MODELS, IMMUNOLOGICAL; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 61349086818     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2008.11.010     Document Type: Review

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