MHC class II signaling in antigen-presenting cells

Current Opinion in Immunology

Volumn 16, Issue 1, 2004, Pages 108-113

  Al Daccak, Reem ^a   Mooney, Nuala ^a   Charron, Dominique ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN FUNCTION; ANTIGEN PRESENTING CELL; ANTIGEN STRUCTURE; APOPTOSIS; CELL ACTIVITY; CELL FATE; CELL MATURATION; CELL PROLIFERATION; MOLECULAR DYNAMICS; MOLECULE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 1042302151     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2003.11.006     Document Type: Review

References (60)

1. Trautmann A., Valitutti S. The diversity of immunological synapses. Curr. Opin. Immunol. 15:2003;249-254.
2. Lang P., Stolpa J.C., Freiberg B.A., Crawford F., Kappler J., Kupfer A., Cambier J.C. TCR induced transmembrane signaling by peptide/MHC class II via associated Ig-a/b dimers. Science. 291:2001;1537-1540.
3. Setterblad N., Roucard C., Bocaccio C., Abastado J.P., Charron D., Mooney N. Composition of MHC class II-enriched lipid microdomains is modified during maturation of primary dendritic cells. J. Leukoc. Biol. 74:2003;40-48.
4. Al-Alwan M.M., Rowden G., Lee T.D., West K.A. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166:2001;1452-1456.
5. Tabata H., Matsuoka T., Endo F., Nishimura Y., Matsushita S. Ligation of HLA-DR molecules on B cells induces enhanced expression of IgM heavy chain genes in association with Syk activation. J. Biol. Chem. 275:2000;34998-35005.
6. Matsuoka T., Tabata H., Matsushita S. Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases. J. Immunol. 166:2001;2202-2208.
7. Matsue H., Edelbaum D., Hartmann A.C., Morita A., Bergstresser P.R., Yagita H., Okumura K., Takashima A. Dendritic cells undergo rapid apoptosis in vitro during antigen-specific interaction with CD4+ T cells. J. Immunol. 162:1999;5287-5298.
8. Boes M., Cerny J., Massol R., Op den Brouw M., Kirchhausen T., Chen J., Ploegh H.L. T cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 418:2002;983-988 The authors studied MHC II transport in live APCs post-recognition of pMHC II on DCs by specific TCRs, and showed that tubular endosomes extend intracellularly and polarize towards the interacting T cell in vivo.
9. Charron D., Brick-Ghannam S., Ramirez R., Mooney N. HLA class-II-mediated B-lymphocyte activation: signal transduction and physiologic consequences. Res. Immunol. 142:1991;467-474.
10. Scholl P.R., Trede N., Chatila T.A., Geha R.S. Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. J. Immunol. 148:1992;2237-2241.
11. Wade W.F., Davoust J., Salamero J., Andre P., Watts T.H., Cambier J.C. Structural compartmentalization of MHC class II signaling function. Immunol. Today. 14:1993;539-546.
12. Scholl P.R., Geha R.S. MHC class II signaling in B-cell activation. Immunol. Today. 15:1994;418-422.
13. Lokshin A.E., Kalinski P., Sassi R.R., Mailliard R.B., Muller-Berghaus J., Storkus W.J., Peng X., Marrangoni A.M., Edwards R.P., Gorelik E. Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. Int. Immunol. 14:2002;1027-1037.
14. Buisson S., Triebel F. MHC class II engagement by its ligand LAG-3 (CD223) leads to a distinct pattern of chemokine and chemokine receptor expression by human dendritic cells. Vaccine. 21:2003;862-868.
15. Andreae S., Piras F., Burdin N., Triebel F. Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J. Immunol. 168:2002;3874-3880.
16. Andreae S., Buisson S., Triebel F. MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). Blood. 102:2003;2130-2137.
17. Gunzer M., Schafer A., Borgmann S., Grabbe S., Zanker K.S., Brocker E.B., Kampgen E., Friedl P. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity. 13:2000;323-332.
18. Bertho N., Drenou B., Laupeze B., Berre C.L., Amiot L., Grosset J.M., Fardel O., Charron D., Mooney N., Fauchet R. HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC. J. Immunol. 164:2000;2379-2385.
19. McLellan A.D., Terbeck G., Mengling T., Starling G.C., Kiener P.A., Gold R., Brocker E.B., Leverkus M., Kampgen E. Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development. Cell Death Differ. 7:2000;933-938.
20. Bertho N., Blancheteau V.M., Setterblad N., Laupeze B., Lord J.M., Drenou B., Amiot L., Charron D.J., Fauchet R., Mooney N. MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-delta isoenzyme. Int. Immunol. 14:2002;935-942.
21. McLellan A., Heldmann M., Terbeck G., Weih F., Linden C., Brocker E.B., Leverkus M., Kampgen E. MHC class II and CD40 play opposing roles in dendritic cell survival. Eur. J. Immunol. 30:2000;2612-2619.
22. Thibeault A., Zekki H., Mourad W., Charron D., Al-Daccak R. Triggering HLA-DR molecules on human peripheral monocytes induces their death. Cell Immunol. 192:1999;79-85.
23. Castaigne J.G., Guo W., Leveille C., Charron D., Al-Daccak R. A CD18-dependent protein kinase C beta-mediated alternative cell death pathway of activated monocytes. Int. Immunol. 14:2002;1003-1014.
24. Truman J.P., Ericson M.L., Choqueux-Seebold C.J., Charron D.J., Mooney N.A. Lymphocyte programmed cell death is mediated via HLA class II DR. Int. Immunol. 6:1994;887-896.
25. Drenou B., Blancheteau V., Burgess D.H., Fauchet R., Charron D.J., Mooney N.A. A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes. J. Immunol. 163:1999;4115-4124.
26. Truman J.P., Choqueux C., Tschopp J., Vedrenne J., Le Deist F., Charron D., Mooney N. HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytes. Blood. 89:1997;1996-2007.
27. Catlett I.M., Xie P., Hostager B.S., Bishop G.A. Signaling through MHC class II molecules blocks CD95-induced apoptosis. J. Immunol. 166:2001;6019-6024.
28. Nagy Z.A., Hubner B., Lohning C., Rauchenberger R., Reiffert S., Thomassen-Wolf E., Zahn S., Leyer S., Schier E.M., Zahradnik A.et al. Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells. Nat. Med. 8:2002;801-807 The authors revealed the importance of MHC II-mediated death in inhibiting the growth of CD95-resistant lymphomas in vivo, and demonstrated the potential of engineered MHC II antibodies as therapeutic tools.
29. Mooney N.A., Grillot-Courvalin C., Hivroz C., Ju L.Y., Charron D. Early biochemical events after MHC class II-mediated signaling on human B lymphocytes. J. Immunol. 145:1990;2070-2076.
30. Cambier J.C., Newell M.K., Justement L.B., McGuire J.C., Leach K.L., Chen Z.Z. Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature. 327:1987;629-632.
31. Brick-Ghannam C., Huang F.L., Temime N., Charron D. Protein kinase C (PKC) activation via human leucocyte antigen class II molecules. A novel regulation of PKC activity. J. Biol. Chem. 266:1991;24169-24175.
32. Guo W., Castaigne J.G., Mooney N., Charron D., Al-Daccak R. Signaling through HLA-DR induces PKCbeta-dependent B cell death outside rafts. Eur. J. Immunol. 33:2003;928-938.
33. Leveille C., Castaigne J.G., Charron D., Al-Daccak R. MHC class II isotype-specific signaling complex on human B cells. Eur. J. Immunol. 32:2002;2282-2291 This study showed that CD20 couples MHC II to tyrosine phosphorylation (in particular to Src kinases) and provided evidence that differential MHC II isotype signaling can result from their differential associations.
34. Bouillon M., El Fakhry Y., Girouard J., Khalil H., Thibodeau J., Mourad W. Lipid raft-dependent and -independent signaling through HLA-DR molecules. J. Biol. Chem. 278:2003;7099-7107.
35. Partida-Sanchez S., Garibay-Escobar A., Frixione E., Parkhouse R.M., Santos-Argumedo L. CD45R, CD44 and MHC class II are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells. Eur. J. Immunol. 30:2000;2722-2728.
36. Andre P., Cambier J.C., Wade T.K., Raetz T., Wade W.F. Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules. J. Exp. Med. 179:1994;763-768.
37. Triantafilou K., Triantafilou M., Fernandez N. Molecular associations and microdomains in antigen-presenting cell-T-cell interactions. Crit. Rev. Immunol. 20:2000;359-373.
38. Boucheix C., Rubinstein E. Tetraspanins. Cell Mol. Life Sci. 58:2001;1189-1205.
39. Leveille C., Al-Daccak R., Mourad W. CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines. Eur. J. Immunol. 29:1999;65-74.
40. Engering A., Pieters J. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells. Int. Immunol. 13:2001;127-134.
41. Vogt A.B., Spindeldreher S., Kropshofer H. Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains. Immunol. Rev. 189:2002;136-151.
42. Deans J.P., Kalt L., Ledbetter J.A., Schieven G.L., Bolen J.B., Johnson P. Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. J. Biol. Chem. 270:1995;22632-22638.
43. Wulfing C., Sumen C., Sjaastad M.D., Wu L.C., Dustin M.L., Davis M.M. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol. 3:2001;42-47.
44. Kropshofer H., Spindeldreher S., Rohn T.A., Platania N., Grygar C., Daniel N., Wolpl A., Langen H., Horejsi V., Vogt A.B. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat. Immunol. 3:2002;61-68.
45. Mittelbrunn M., Yanez-Mo M., Sancho D., Ursa A., Sanchez-Madrid F. Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC. J. Immunol. 169:2002;6691-6695.
46. Bobbitt K.R., Justement L.B. Regulation of MHC class II signal transduction by the B cell coreceptors CD19 and CD22. J. Immunol. 165:2000;5588-5596.
47. Dib K. BETA 2 integrin signaling in leukocytes. Front Biosci. 5:2000;D438-D451.
48. Rich T., Lawler S.E., Lord J.M., Blancheteau V.M., Charron D.J., Mooney N.A. HLA class II-induced translocation of PKC alpha and PKC beta II isoforms is abrogated following truncation of DR beta cytoplasmic domains. J. Immunol. 159:1997;3792-3798.
49. Anderson H., Hitbold A., Roche A. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1:2000;156-162.
50. Setterblad N., Becart S., Charron D., Mooney N. Signalling via MHC class II molecules modifies the composition of GEMs in APC. Scand. J. Immunol. 54:2001;87-92.
51. Huby R.D., Dearman R.J., Kimber I. Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J. Biol. Chem. 274:1999;22591-22596.
52. Becart S., Setterblad N., Ostrand-Rosenberg S., Ono S.J., Charron D., Mooney N. Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling. J. Cell Sci. 116:2003;2565-2575 In a murine sarcoma model the translocation of MHC II molecules to lipid rafts did not require the cytoplasmic tail. In addition, this study ordered lipid-raft-mediated events following engagement of the MHC II molecules.
53. Hiltbold E.M., Poloso N.J., Roche P.A. MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J. Immunol. 170:2003;1329-1338 This study evaluates the importance of APC lipid rafts during the initial events of T-cell activation by addressing their role in the formation of conjugates between antigen-specific T cells and antigen-loaded APCs.
54. Kaufman J.F., Krangel M.S., Strominger J.L. Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. J. Biol. Chem. 259:1984;7230-7238.
55. El-Husseini Ael D., Schnell E., Dakoji S., Sweeney N., Zhou Q., Prange O., Gauthier-Campbell C., Aguilera-Moreno A., Nicoll R.A., Bredt D.S. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 108:2002;849-863.
56. Bishop G.A., Frelinger J.A. Haplotype-specific differences in signaling by transfected class II molecules to a Ly-1+ B-cell clone. Proc. Natl. Acad. Sci. U.S.A. 86:1989;5933-5937.
57. Guo W., Mourad W., Charron D., Al-Daccak R. Ligation of MHC class II molecules differentially upregulates TNF beta gene expression in B cell lines of different MHC class II haplotypes. Hum. Immunol. 60:1999;312-322.
58. Herman A., Croteau G., Sekaly R.P., Kappler J., Marrack P. HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J. Exp. Med. 172:1990;709-717.
59. Kotb M., Norrby-Teglund A., McGeer A., El-Sherbini H., Dorak M.T., Khurshid A., Green K., Peeples J., Wade J., Thomson G., Schwartz B., Low D.E. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat. Med. 8:2002;1398-1404 This study shows that MHC II allelic variation contributes to differences in severity of invasive streptococcal infections through their ability to regulate differential cytokine response to streptococcal superantigens.
60. Laplanche J.L., Lepage V., Peoc'h K., Delasnerie-Laupretre N., Charron D. HLA in French patients with variant Creutzfeldt-Jakob disease. Lancet. 361:2003;531-532.