메뉴 건너뛰기




Volumn 287, Issue 23, 2012, Pages 18937-18952

Roles of Kruppel-associated box (KRAB)-associated co-repressor KAP1 Ser-473 phosphorylation in DNA damage response

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA-TELANGIECTASIA MUTATED; CELL SURVIVAL; CHROMATIN CONDENSATION; COREPRESSORS; DNA DAMAGE RESPONSE; DNA DAMAGES; DNA REPAIR; INDUCED APOPTOSIS; KRUPPEL-ASSOCIATED BOXES; NOVEL FUNCTIONS; OVER-EXPRESSION; PRO-APOPTOTIC GENES; SIGNALING CASCADES; TARGET GENES; TRANSCRIPTIONAL FACTORS; TRANSCRIPTIONAL REPRESSION; ZINC FINGER PROTEIN;

EID: 84861748047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.313262     Document Type: Article
Times cited : (68)

References (56)
  • 2
    • 0033915781 scopus 로고    scopus 로고
    • Mice lacking the transcriptional corepressor TIF1η are defective in early postimplantation development
    • Cammas, F., Mark, M., Dollé, P., Dierich, A., Chambon, P., and Losson, R. (2000) Mice lacking the transcriptional corepressor TIF1β are defective in early postimplantation development. Development 127, 2955-2963 (Pubitemid 30487613)
    • (2000) Development , vol.127 , Issue.13 , pp. 2955-2963
    • Cammas, F.1    Mark, M.2    Dolle, P.3    Dierich, A.4    Chambon, P.5    Losson, R.6
  • 3
    • 0036340070 scopus 로고    scopus 로고
    • Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse
    • Weber, P., Cammas, F., Gerard, C., Metzger, D., Chambon, P., Losson, R., and Mark, M. (2002) Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse. Development 129, 2329-2337 (Pubitemid 34863842)
    • (2002) Development , vol.129 , Issue.10 , pp. 2329-2337
    • Weber, P.1    Cammas, F.2    Gerard, C.3    Metzger, D.4    Chambon, P.5    Losson, R.6    Mark, M.7
  • 4
    • 0034602922 scopus 로고    scopus 로고
    • Reconstitution of the KRAB-KAP-1 repressor complex: A model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions
    • Peng, H., Begg, G. E., Schultz, D. C., Friedman, J. R., Jensen, D. E., Speicher, D. W., and Rauscher, F. J., 3rd (2000) Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J. Mol. Biol. 295, 1139-1162
    • (2000) J. Mol. Biol. , vol.295 , pp. 1139-1162
    • Peng, H.1    Begg, G.E.2    Schultz, D.C.3    Friedman, J.R.4    Jensen, D.E.5    Speicher, D.W.6    Rauscher III, F.J.7
  • 5
    • 0033838255 scopus 로고    scopus 로고
    • Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
    • DOI 10.1128/MCB.20.17.6449-6465.2000
    • Lechner, M. S., Begg, G. E., Speicher, D. W., and Rauscher, F. J., 3rd (2000) Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell. Biol. 20, 6449-6465 (Pubitemid 30650232)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.17 , pp. 6449-6465
    • Lechner, M.S.1    Begg, G.E.2    Speicher, D.W.3    Rauscher III, F.J.4
  • 6
    • 0035118229 scopus 로고    scopus 로고
    • Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD
    • DOI 10.1101/gad.869501
    • Schultz, D. C., Friedman, J. R., and Rauscher, F. J., 3rd (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev. 15, 428-443 (Pubitemid 32187004)
    • (2001) Genes and Development , vol.15 , Issue.4 , pp. 428-443
    • Schultz, D.C.1    Friedman, J.R.2    Rauscher III, F.J.3
  • 7
    • 0033013868 scopus 로고    scopus 로고
    • KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box- zinc finger proteins in heterochromatin-mediated gene silencing
    • Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., and Rauscher, F. J., 3rd (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol. Cell. Biol. 19, 4366-4378 (Pubitemid 29242011)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.6 , pp. 4366-4378
    • Ryan, R.F.1    Schultz, D.C.2    Ayyanathan, K.3    Singh, P.B.4    Friedman, J.R.5    Fredericks, W.J.6    Rauscher III, F.J.7
  • 8
    • 33751007001 scopus 로고    scopus 로고
    • The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression
    • DOI 10.1128/MCB.00487-06
    • Sripathy, S. P., Stevens, J., and Schultz, D. C. (2006) The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol. Cell. Biol. 26, 8623-8638 (Pubitemid 44748593)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.22 , pp. 8623-8638
    • Sripathy, S.P.1    Stevens, J.2    Schultz, D.C.3
  • 9
    • 16844362291 scopus 로고    scopus 로고
    • Activation of p27Kip1 expression by E2F1. A negative feedback mechanism
    • Wang, C., Hou, X., Mohapatra, S., Ma, Y., Cress, W. D., Pledger, W. J., and Chen, J. (2005) Activation of p27Kip1 expression by E2F1. A negative feedback mechanism. J. Biol. Chem. 280, 12339-12343
    • (2005) J. Biol. Chem. , vol.280 , pp. 12339-12343
    • Wang, C.1    Hou, X.2    Mohapatra, S.3    Ma, Y.4    Cress, W.D.5    Pledger, W.J.6    Chen, J.7
  • 10
    • 35649016616 scopus 로고    scopus 로고
    • Regulation of E2F1 function by the nuclear corepressor KAP1
    • DOI 10.1074/jbc.M704757200
    • Wang, C., Rauscher, F. J., 3rd, Cress, W. D., and Chen, J. (2007) Regulation of E2F1 function by the nuclear corepressor KAP1. J. Biol. Chem. 282, 29902-29909 (Pubitemid 350035243)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.41 , pp. 29902-29909
    • Wang, C.1    Rauscher III, F.J.2    Cress, W.D.3    Chen, J.4
  • 11
    • 33750373155 scopus 로고    scopus 로고
    • KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction
    • DOI 10.1016/j.bbrc.2006.10.022, PII S0006291X0602256X
    • Okamoto, K., Kitabayashi, I., and Taya, Y. (2006) KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochem. Biophys. Res. Commun. 351, 216-222 (Pubitemid 44635429)
    • (2006) Biochemical and Biophysical Research Communications , vol.351 , Issue.1 , pp. 216-222
    • Okamoto, K.1    Kitabayashi, I.2    Taya, Y.3
  • 12
    • 25144496653 scopus 로고    scopus 로고
    • MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
    • DOI 10.1038/sj.emboj.7600791, PII 7600791
    • Wang, C., Ivanov, A., Chen, L., Fredericks, W. J., Seto, E., Rauscher, F. J., 3rd, and Chen, J. (2005) MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 24, 3279-3290 (Pubitemid 41348702)
    • (2005) EMBO Journal , vol.24 , Issue.18 , pp. 3279-3290
    • Wang, C.1    Ivanov, A.2    Chen, L.3    Fredericks, W.J.4    Seto, E.5    Rauscher III, F.J.6    Chen, J.7
  • 14
    • 34249853932 scopus 로고    scopus 로고
    • Sumoylation of the transcriptional intermediary factor 1β (TIF1β), the Co-repressor of the KRAB multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain
    • DOI 10.1074/jbc.M611429200
    • Mascle, X. H., Germain-Desprez, D., Huynh, P., Estephan, P., and Aubry, M. (2007) Sumoylation of the transcriptional intermediary factor 1β(TIF1β), the co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain. J. Biol. Chem. 282, 10190-10202 (Pubitemid 47093398)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.14 , pp. 10190-10202
    • Mascle, X.H.1    Germain-Desprez, D.2    Huynh, P.3    Estephan, P.4    Aubry, M.5
  • 15
    • 33746601439 scopus 로고    scopus 로고
    • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway
    • DOI 10.1038/ncb1446, PII NCB1446
    • Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., and Shiloh, Y. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876 (Pubitemid 44151591)
    • (2006) Nature Cell Biology , vol.8 , Issue.8 , pp. 870-876
    • Ziv, Y.1    Bielopolski, D.2    Galanty, Y.3    Lukas, C.4    Taya, Y.5    Schultz, D.C.6    Lukas, J.7    Bekker-Jensen, S.8    Bartek, J.9    Shiloh, Y.10
  • 16
    • 75949122330 scopus 로고    scopus 로고
    • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    • Noon, A. T., Shibata, A., Rief, N., Löbrich, M., Stewart, G. S., Jeggo, P. A., and Goodarzi, A. A. (2010) 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184
    • (2010) Nat. Cell Biol. , vol.12 , pp. 177-184
    • Noon, A.T.1    Shibata, A.2    Rief, N.3    Löbrich, M.4    Stewart, G.S.5    Jeggo, P.A.6    Goodarzi, A.A.7
  • 17
    • 47349107760 scopus 로고    scopus 로고
    • ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
    • DOI 10.1016/j.molcel.2008.05.017, PII S109727650800395X
    • Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., and Jeggo, P. A. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31, 167-177 (Pubitemid 352001394)
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 18
    • 79960055393 scopus 로고    scopus 로고
    • KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response
    • Goodarzi, A. A., Kurka, T., and Jeggo, P. A. (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat. Struct. Mol. Biol. 18, 831-839
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 831-839
    • Goodarzi, A.A.1    Kurka, T.2    Jeggo, P.A.3
  • 19
    • 37549021501 scopus 로고    scopus 로고
    • Role for KAP1 serine 824 phosphorylation and sumoylation/ desumoylation switch in regulating KAP1-mediated transcriptional repression
    • Li, X., Lee, Y. K., Jeng, J. C., Yen, Y., Schultz, D. C., Shih, H. M., and Ann, D. K. (2007) Role for KAP1 serine 824 phosphorylation and sumoylation/ desumoylation switch in regulating KAP1-mediated transcriptional repression. J. Biol. Chem. 282, 36177-36189
    • (2007) J. Biol. Chem. , vol.282 , pp. 36177-36189
    • Li, X.1    Lee, Y.K.2    Jeng, J.C.3    Yen, Y.4    Schultz, D.C.5    Shih, H.M.6    Ann, D.K.7
  • 20
    • 47749150659 scopus 로고    scopus 로고
    • Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1β/KAP1
    • Chang, C. W., Chou, H. Y., Lin, Y. S., Huang, K. H., Chang, C. J., Hsu, T. C., and Lee, S. C. (2008) Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1β/KAP1.BMCMol. Biol. 9, 61
    • (2008) BMCMol. Biol. , vol.9 , pp. 61
    • Chang, C.W.1    Chou, H.Y.2    Lin, Y.S.3    Huang, K.H.4    Chang, C.J.5    Hsu, T.C.6    Lee, S.C.7
  • 25
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
    • Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y., and Prives, C. (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (Pubitemid 30106484)
    • (2000) Genes and Development , vol.14 , Issue.3 , pp. 289-300
    • Shieh, S.-Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 26
    • 0037073737 scopus 로고    scopus 로고
    • Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation
    • DOI 10.1074/jbc.M208321200
    • Ahn, J., and Prives, C. (2002) Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J. Biol. Chem. 277, 48418-48426 (Pubitemid 35470799)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48418-48426
    • Ahn, J.1    Prives, C.2
  • 28
    • 0038752083 scopus 로고    scopus 로고
    • Chk2 activates E2F-1 in response to DNA damage
    • DOI 10.1038/ncb974
    • Stevens, C., Smith, L., and La Thangue, N. B. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5, 401-409 (Pubitemid 36592262)
    • (2003) Nature Cell Biology , vol.5 , Issue.5 , pp. 401-409
    • Stevens, C.1    Smith, L.2    La, T.N.B.3
  • 29
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • DOI 10.1016/S0955-0674(00)00201-5
    • Durocher, D., and Jackson, S. P. (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13, 225-231 (Pubitemid 32209224)
    • (2001) Current Opinion in Cell Biology , vol.13 , Issue.2 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 30
    • 0028937738 scopus 로고
    • Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro
    • Hall, T. J., Jeker, H., and Schaueblin, M. (1995) Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif. Tissue Int. 56, 336-338
    • (1995) Calcif. Tissue Int. , vol.56 , pp. 336-338
    • Hall, T.J.1    Jeker, H.2    Schaueblin, M.3
  • 31
    • 11344286593 scopus 로고    scopus 로고
    • 2/M transition and S phase progression in response to UV irradiation
    • DOI 10.1016/j.molcel.2004.11.021, PII S1097276504007129
    • Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E., and Yaffe, M. B. (2005) MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell 17, 37-48 (Pubitemid 40075363)
    • (2005) Molecular Cell , vol.17 , Issue.1 , pp. 37-48
    • Manke, I.A.1    Nguyen, A.2    Lim, D.3    Stewart, M.Q.4    Elia, A.E.H.5    Yaffe, M.B.6
  • 32
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • DOI 10.1074/jbc.274.53.37538
    • Kim, S. T., Lim, D. S., Canman, C. E., and Kastan, M. B. (1999) Substrate specificities and identification of putative substrates ofATMkinase family members. J. Biol. Chem. 274, 37538-37543 (Pubitemid 30026807)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.53 , pp. 37538-37543
    • Kim, S.-T.1    Lim, D.-S.2    Canman, C.E.3    Kastan, M.B.4
  • 34
    • 0035951809 scopus 로고    scopus 로고
    • Characterization of tumor-associated Chk2 mutations
    • Wu, X., Webster, S. R., and Chen, J. (2001) Characterization of tumor-associated Chk2 mutations. J. Biol. Chem. 276, 2971-2974
    • (2001) J. Biol. Chem. , vol.276 , pp. 2971-2974
    • Wu, X.1    Webster, S.R.2    Chen, J.3
  • 35
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
    • DOI 10.1038/nrc2251, PII NRC2251
    • Antoni, L., Sodha, N., Collins, I., and Garrett, M. D. (2007) CHK2 kinase: cancer susceptibility and cancer therapy-two sides of the same coin? Nat. Rev. Cancer 7, 925-936 (Pubitemid 350165855)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.12 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 36
    • 33847270257 scopus 로고    scopus 로고
    • WAF1/CIP1 in Breast cancer MCF-7 cells
    • DOI 10.1074/jbc.M606306200
    • Lee, Y. K., Thomas, S. N., Yang, A. J., and Ann, D. K. (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J. Biol. Chem. 282, 1595-1606 (Pubitemid 47076713)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.3 , pp. 1595-1606
    • Lee, Y.-K.1    Thomas, S.N.2    Yang, A.J.3    Ann, D.K.4
  • 38
    • 84855341201 scopus 로고    scopus 로고
    • BRCA1 forms a functional complex with γ-H2AX as a late response to genotoxic stress
    • pii: 801594
    • Krum, S. A., la Rosa Dalugdugan, E., Miranda-Carboni, G. A., and Lane, T. F. (2010) BRCA1 forms a functional complex with γ-H2AX as a late response to genotoxic stress. J. Nucleic Acids 2010, pii: 801594
    • (2010) J. Nucleic Acids , vol.2010
    • Krum, S.A.1    La Rosa Dalugdugan, E.2    Miranda-Carboni, G.A.3    Lane, T.F.4
  • 39
    • 33846194613 scopus 로고    scopus 로고
    • KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions
    • DOI 10.1158/0008-5472.CAN-06-4138
    • White, D. E., Negorev, D., Peng, H., Ivanov, A. V., Maul, G. G., and Rauscher, F. J., 3rd (2006) KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 66, 11594-11599 (Pubitemid 46094169)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11594-11599
    • White, D.E.1    Negorev, D.2    Peng, H.3    Ivanov, A.V.4    Maul, G.G.5    Rauscher III, F.J.6
  • 40
    • 77954065271 scopus 로고    scopus 로고
    • I-TASSER: A unified platform for automated protein structure and function prediction
    • Roy, A., Kucukural, A., and Zhang, Y. (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat. Protoc. 5, 725-738
    • (2010) Nat. Protoc. , vol.5 , pp. 725-738
    • Roy, A.1    Kucukural, A.2    Zhang, Y.3
  • 41
  • 42
    • 78650081714 scopus 로고    scopus 로고
    • ZNF274 recruits the histone methyltransferase SETDB1 to the 3′ ends of ZNF genes
    • Frietze, S., O'Geen, H., Blahnik, K. R., Jin, V. X., and Farnham, P. J. (2010) ZNF274 recruits the histone methyltransferase SETDB1 to the 3′ ends of ZNF genes. PLoS One 5, e15082
    • (2010) PLoS One , vol.5
    • Frietze, S.1    O'Geen, H.2    Blahnik, K.R.3    Jin, V.X.4    Farnham, P.J.5
  • 43
    • 0035136902 scopus 로고    scopus 로고
    • Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein
    • DOI 10.1128/MCB.21.3.928-939.2001
    • Gebelein, B., and Urrutia, R. (2001) Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein. Mol. Cell. Biol. 21, 928-939 (Pubitemid 32104740)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.3 , pp. 928-939
    • Gebelein, B.1    Urrutia, R.2
  • 45
    • 33744982924 scopus 로고    scopus 로고
    • ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene
    • Kherrouche, Z., Blais, A., Ferreira, E., De Launoit, Y., and Monté, D. (2006) ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene. Biochem. J. 396, 547-556
    • (2006) Biochem. J. , vol.396 , pp. 547-556
    • Kherrouche, Z.1    Blais, A.2    Ferreira, E.3    De Launoit, Y.4    Monté, D.5
  • 46
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe, T., and Pützer, B. M. (2000) Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat. Genet. 26, 464-469
    • (2000) Nat. Genet. , vol.26 , pp. 464-469
    • Stiewe, T.1    Pützer, B.M.2
  • 50
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • DOI 10.1128/MCB.23.16.5706-5715.2003
    • Rothkamm, K., Krüger, I., Thompson, L. H., and Löbrich, M. (2003) Pathways ofDNAdouble-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23, 5706-5715 (Pubitemid 36951334)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 51
    • 77953166592 scopus 로고    scopus 로고
    • γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
    • Löbrich, M., Shibata, A., Beucher, A., Fisher, A., Ensminger, M., Goodarzi, A. A., Barton, O., and Jeggo, P. A. (2010) γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle 9, 662-669
    • (2010) Cell Cycle , vol.9 , pp. 662-669
    • Löbrich, M.1    Shibata, A.2    Beucher, A.3    Fisher, A.4    Ensminger, M.5    Goodarzi, A.A.6    Barton, O.7    Jeggo, P.A.8
  • 52
    • 4944234150 scopus 로고    scopus 로고
    • Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    • DOI 10.1158/0008-5472.CAN-04-1433
    • Banáth, J. P., Macphail, S. H., and Olive, P. L. (2004) Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res. 64, 7144-7149 (Pubitemid 39331029)
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 7144-7149
    • Banath, J.P.1    MacPhail, S.H.2    Olive, P.L.3
  • 53
    • 79960677839 scopus 로고    scopus 로고
    • KAP1 protein: An enigmatic master regulator of the genome
    • Iyengar, S., and Farnham, P. J. (2011) KAP1 protein: an enigmatic master regulator of the genome. J. Biol. Chem. 286, 26267-26276
    • (2011) J. Biol. Chem. , vol.286 , pp. 26267-26276
    • Iyengar, S.1    Farnham, P.J.2
  • 56
    • 0035878122 scopus 로고    scopus 로고
    • Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
    • Lin, W. C., Lin, F. T., and Nevins, J. R. (2001) Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 15, 1833-1844
    • (2001) Genes Dev. , vol.15 , pp. 1833-1844
    • Lin, W.C.1    Lin, F.T.2    Nevins, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.