-
1
-
-
0029858585
-
KAP-1, a novel corepressor for the highly conserved KRAB repression domain
-
Friedman, J. R., Fredericks, W. J., Jensen, D. E., Speicher, D. W., Huang, X. P., Neilson, E. G., and Rauscher, F. J., 3rd (1996) KAP-1, a novel core-pressor for the highly conserved KRAB repression domain. Genes Dev. 10, 2067-2078 (Pubitemid 26346114)
-
(1996)
Genes and Development
, vol.10
, Issue.16
, pp. 2067-2078
-
-
Friedman, J.R.1
Fredericks, W.J.2
Jensen, D.E.3
Speicher, D.W.4
Huang, X.-P.5
Neilson, E.G.6
Rauscher III, F.J.7
-
2
-
-
0033915781
-
Mice lacking the transcriptional corepressor TIF1η are defective in early postimplantation development
-
Cammas, F., Mark, M., Dollé, P., Dierich, A., Chambon, P., and Losson, R. (2000) Mice lacking the transcriptional corepressor TIF1β are defective in early postimplantation development. Development 127, 2955-2963 (Pubitemid 30487613)
-
(2000)
Development
, vol.127
, Issue.13
, pp. 2955-2963
-
-
Cammas, F.1
Mark, M.2
Dolle, P.3
Dierich, A.4
Chambon, P.5
Losson, R.6
-
3
-
-
0036340070
-
Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse
-
Weber, P., Cammas, F., Gerard, C., Metzger, D., Chambon, P., Losson, R., and Mark, M. (2002) Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse. Development 129, 2329-2337 (Pubitemid 34863842)
-
(2002)
Development
, vol.129
, Issue.10
, pp. 2329-2337
-
-
Weber, P.1
Cammas, F.2
Gerard, C.3
Metzger, D.4
Chambon, P.5
Losson, R.6
Mark, M.7
-
4
-
-
0034602922
-
Reconstitution of the KRAB-KAP-1 repressor complex: A model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions
-
Peng, H., Begg, G. E., Schultz, D. C., Friedman, J. R., Jensen, D. E., Speicher, D. W., and Rauscher, F. J., 3rd (2000) Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J. Mol. Biol. 295, 1139-1162
-
(2000)
J. Mol. Biol.
, vol.295
, pp. 1139-1162
-
-
Peng, H.1
Begg, G.E.2
Schultz, D.C.3
Friedman, J.R.4
Jensen, D.E.5
Speicher, D.W.6
Rauscher III, F.J.7
-
5
-
-
0033838255
-
Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
-
DOI 10.1128/MCB.20.17.6449-6465.2000
-
Lechner, M. S., Begg, G. E., Speicher, D. W., and Rauscher, F. J., 3rd (2000) Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell. Biol. 20, 6449-6465 (Pubitemid 30650232)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.17
, pp. 6449-6465
-
-
Lechner, M.S.1
Begg, G.E.2
Speicher, D.W.3
Rauscher III, F.J.4
-
6
-
-
0035118229
-
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD
-
DOI 10.1101/gad.869501
-
Schultz, D. C., Friedman, J. R., and Rauscher, F. J., 3rd (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev. 15, 428-443 (Pubitemid 32187004)
-
(2001)
Genes and Development
, vol.15
, Issue.4
, pp. 428-443
-
-
Schultz, D.C.1
Friedman, J.R.2
Rauscher III, F.J.3
-
7
-
-
0033013868
-
KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box- zinc finger proteins in heterochromatin-mediated gene silencing
-
Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., and Rauscher, F. J., 3rd (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol. Cell. Biol. 19, 4366-4378 (Pubitemid 29242011)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.6
, pp. 4366-4378
-
-
Ryan, R.F.1
Schultz, D.C.2
Ayyanathan, K.3
Singh, P.B.4
Friedman, J.R.5
Fredericks, W.J.6
Rauscher III, F.J.7
-
8
-
-
33751007001
-
The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression
-
DOI 10.1128/MCB.00487-06
-
Sripathy, S. P., Stevens, J., and Schultz, D. C. (2006) The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol. Cell. Biol. 26, 8623-8638 (Pubitemid 44748593)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.22
, pp. 8623-8638
-
-
Sripathy, S.P.1
Stevens, J.2
Schultz, D.C.3
-
9
-
-
16844362291
-
Activation of p27Kip1 expression by E2F1. A negative feedback mechanism
-
Wang, C., Hou, X., Mohapatra, S., Ma, Y., Cress, W. D., Pledger, W. J., and Chen, J. (2005) Activation of p27Kip1 expression by E2F1. A negative feedback mechanism. J. Biol. Chem. 280, 12339-12343
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 12339-12343
-
-
Wang, C.1
Hou, X.2
Mohapatra, S.3
Ma, Y.4
Cress, W.D.5
Pledger, W.J.6
Chen, J.7
-
10
-
-
35649016616
-
Regulation of E2F1 function by the nuclear corepressor KAP1
-
DOI 10.1074/jbc.M704757200
-
Wang, C., Rauscher, F. J., 3rd, Cress, W. D., and Chen, J. (2007) Regulation of E2F1 function by the nuclear corepressor KAP1. J. Biol. Chem. 282, 29902-29909 (Pubitemid 350035243)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.41
, pp. 29902-29909
-
-
Wang, C.1
Rauscher III, F.J.2
Cress, W.D.3
Chen, J.4
-
11
-
-
33750373155
-
KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction
-
DOI 10.1016/j.bbrc.2006.10.022, PII S0006291X0602256X
-
Okamoto, K., Kitabayashi, I., and Taya, Y. (2006) KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochem. Biophys. Res. Commun. 351, 216-222 (Pubitemid 44635429)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.1
, pp. 216-222
-
-
Okamoto, K.1
Kitabayashi, I.2
Taya, Y.3
-
12
-
-
25144496653
-
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
-
DOI 10.1038/sj.emboj.7600791, PII 7600791
-
Wang, C., Ivanov, A., Chen, L., Fredericks, W. J., Seto, E., Rauscher, F. J., 3rd, and Chen, J. (2005) MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 24, 3279-3290 (Pubitemid 41348702)
-
(2005)
EMBO Journal
, vol.24
, Issue.18
, pp. 3279-3290
-
-
Wang, C.1
Ivanov, A.2
Chen, L.3
Fredericks, W.J.4
Seto, E.5
Rauscher III, F.J.6
Chen, J.7
-
13
-
-
36749009119
-
PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain Required for Gene Silencing
-
DOI 10.1016/j.molcel.2007.11.012, PII S1097276507007800
-
Ivanov, A. V., Peng, H., Yurchenko, V., Yap, K. L., Negorev, D. G., Schultz, D. C., Psulkowski, E., Fredericks, W. J., White, D. E., Maul, G. G., Sadofsky, M. J., Zhou, M. M., and Rauscher, F. J., 3rd (2007) PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol. Cell 28, 823-837 (Pubitemid 350217061)
-
(2007)
Molecular Cell
, vol.28
, Issue.5
, pp. 823-837
-
-
Ivanov, A.V.1
Peng, H.2
Yurchenko, V.3
Yap, K.L.4
Negorev, D.G.5
Schultz, D.C.6
Psulkowski, E.7
Fredericks, W.J.8
White, D.E.9
Maul, G.G.10
Sadofsky, M.J.11
Zhou, M.-M.12
Rauscher III, F.J.13
-
14
-
-
34249853932
-
Sumoylation of the transcriptional intermediary factor 1β (TIF1β), the Co-repressor of the KRAB multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain
-
DOI 10.1074/jbc.M611429200
-
Mascle, X. H., Germain-Desprez, D., Huynh, P., Estephan, P., and Aubry, M. (2007) Sumoylation of the transcriptional intermediary factor 1β(TIF1β), the co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain. J. Biol. Chem. 282, 10190-10202 (Pubitemid 47093398)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.14
, pp. 10190-10202
-
-
Mascle, X.H.1
Germain-Desprez, D.2
Huynh, P.3
Estephan, P.4
Aubry, M.5
-
15
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway
-
DOI 10.1038/ncb1446, PII NCB1446
-
Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., and Shiloh, Y. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876 (Pubitemid 44151591)
-
(2006)
Nature Cell Biology
, vol.8
, Issue.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
-
16
-
-
75949122330
-
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
-
Noon, A. T., Shibata, A., Rief, N., Löbrich, M., Stewart, G. S., Jeggo, P. A., and Goodarzi, A. A. (2010) 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 177-184
-
-
Noon, A.T.1
Shibata, A.2
Rief, N.3
Löbrich, M.4
Stewart, G.S.5
Jeggo, P.A.6
Goodarzi, A.A.7
-
17
-
-
47349107760
-
ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
-
DOI 10.1016/j.molcel.2008.05.017, PII S109727650800395X
-
Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., and Jeggo, P. A. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31, 167-177 (Pubitemid 352001394)
-
(2008)
Molecular Cell
, vol.31
, Issue.2
, pp. 167-177
-
-
Goodarzi, A.A.1
Noon, A.T.2
Deckbar, D.3
Ziv, Y.4
Shiloh, Y.5
Lobrich, M.6
Jeggo, P.A.7
-
18
-
-
79960055393
-
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response
-
Goodarzi, A. A., Kurka, T., and Jeggo, P. A. (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat. Struct. Mol. Biol. 18, 831-839
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 831-839
-
-
Goodarzi, A.A.1
Kurka, T.2
Jeggo, P.A.3
-
19
-
-
37549021501
-
Role for KAP1 serine 824 phosphorylation and sumoylation/ desumoylation switch in regulating KAP1-mediated transcriptional repression
-
Li, X., Lee, Y. K., Jeng, J. C., Yen, Y., Schultz, D. C., Shih, H. M., and Ann, D. K. (2007) Role for KAP1 serine 824 phosphorylation and sumoylation/ desumoylation switch in regulating KAP1-mediated transcriptional repression. J. Biol. Chem. 282, 36177-36189
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 36177-36189
-
-
Li, X.1
Lee, Y.K.2
Jeng, J.C.3
Yen, Y.4
Schultz, D.C.5
Shih, H.M.6
Ann, D.K.7
-
20
-
-
47749150659
-
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1β/KAP1
-
Chang, C. W., Chou, H. Y., Lin, Y. S., Huang, K. H., Chang, C. J., Hsu, T. C., and Lee, S. C. (2008) Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1β/KAP1.BMCMol. Biol. 9, 61
-
(2008)
BMCMol. Biol.
, vol.9
, pp. 61
-
-
Chang, C.W.1
Chou, H.Y.2
Lin, Y.S.3
Huang, K.H.4
Chang, C.J.5
Hsu, T.C.6
Lee, S.C.7
-
21
-
-
77953148666
-
Site-specific phosphorylation dynamics of the nuclear proteome during theDNAdamage response
-
Bennetzen, M. V., Larsen, D. H., Bunkenborg, J., Bartek, J., Lukas, J., and Andersen, J. S. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during theDNAdamage response. Mol. Cell. Proteomics 9, 1314-1323
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1314-1323
-
-
Bennetzen, M.V.1
Larsen, D.H.2
Bunkenborg, J.3
Bartek, J.4
Lukas, J.5
Andersen, J.S.6
-
22
-
-
80051793361
-
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
-
Blasius, M., Forment, J. V., Thakkar, N., Wagner, S. A., Choudhary, C., and Jackson, S. P. (2011) A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol. 12, R78
-
(2011)
Genome Biol.
, vol.12
-
-
Blasius, M.1
Forment, J.V.2
Thakkar, N.3
Wagner, S.A.4
Choudhary, C.5
Jackson, S.P.6
-
23
-
-
0035656415
-
CHK2 kinase-a busy messenger
-
Bartek, J., Falck, J., and Lukas, J. (2001) CHK2 kinase-a busy messenger. Nat. Rev. Mol. Cell. Biol. 2, 877-886
-
(2001)
Nat. Rev. Mol. Cell. Biol.
, vol.2
, pp. 877-886
-
-
Bartek, J.1
Falck, J.2
Lukas, J.3
-
24
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
-
Hirao, A., Cheung, A., Duncan, G., Girard, P. M., Elia, A. J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., De Stanchina, E., Bristow, R. G., Suda, T., Lowe, S. W., Jeggo, P. A., Elledge, S. J., and Mak, T. W. (2002) Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol. Cell. Biol. 22, 6521-6532
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
Cheung, A.2
Duncan, G.3
Girard, P.M.4
Elia, A.J.5
Wakeham, A.6
Okada, H.7
Sarkissian, T.8
Wong, J.A.9
Sakai, T.10
De Stanchina, E.11
Bristow, R.G.12
Suda, T.13
Lowe, S.W.14
Jeggo, P.A.15
Elledge, S.J.16
Mak, T.W.17
-
25
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
-
Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y., and Prives, C. (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (Pubitemid 30106484)
-
(2000)
Genes and Development
, vol.14
, Issue.3
, pp. 289-300
-
-
Shieh, S.-Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
26
-
-
0037073737
-
Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation
-
DOI 10.1074/jbc.M208321200
-
Ahn, J., and Prives, C. (2002) Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J. Biol. Chem. 277, 48418-48426 (Pubitemid 35470799)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.50
, pp. 48418-48426
-
-
Ahn, J.1
Prives, C.2
-
27
-
-
57049100896
-
ATM and Chk2 kinase target the p53 cofactor Strap
-
Adams, C. J., Graham, A. L., Jansson, M., Coutts, A. S., Edelmann, M., Smith, L., Kessler, B., La Thangue, N. B. (2008) ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep. 9, 1222-1229
-
(2008)
EMBO Rep.
, vol.9
, pp. 1222-1229
-
-
Adams, C.J.1
Graham, A.L.2
Jansson, M.3
Coutts, A.S.4
Edelmann, M.5
Smith, L.6
Kessler, B.7
La Thangue, N.B.8
-
28
-
-
0038752083
-
Chk2 activates E2F-1 in response to DNA damage
-
DOI 10.1038/ncb974
-
Stevens, C., Smith, L., and La Thangue, N. B. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5, 401-409 (Pubitemid 36592262)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.5
, pp. 401-409
-
-
Stevens, C.1
Smith, L.2
La, T.N.B.3
-
29
-
-
0035313706
-
DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
-
DOI 10.1016/S0955-0674(00)00201-5
-
Durocher, D., and Jackson, S. P. (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13, 225-231 (Pubitemid 32209224)
-
(2001)
Current Opinion in Cell Biology
, vol.13
, Issue.2
, pp. 225-231
-
-
Durocher, D.1
Jackson, S.P.2
-
30
-
-
0028937738
-
Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro
-
Hall, T. J., Jeker, H., and Schaueblin, M. (1995) Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif. Tissue Int. 56, 336-338
-
(1995)
Calcif. Tissue Int.
, vol.56
, pp. 336-338
-
-
Hall, T.J.1
Jeker, H.2
Schaueblin, M.3
-
31
-
-
11344286593
-
2/M transition and S phase progression in response to UV irradiation
-
DOI 10.1016/j.molcel.2004.11.021, PII S1097276504007129
-
Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E., and Yaffe, M. B. (2005) MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell 17, 37-48 (Pubitemid 40075363)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
32
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
DOI 10.1074/jbc.274.53.37538
-
Kim, S. T., Lim, D. S., Canman, C. E., and Kastan, M. B. (1999) Substrate specificities and identification of putative substrates ofATMkinase family members. J. Biol. Chem. 274, 37538-37543 (Pubitemid 30026807)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.53
, pp. 37538-37543
-
-
Kim, S.-T.1
Lim, D.-S.2
Canman, C.E.3
Kastan, M.B.4
-
33
-
-
20144371717
-
Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles
-
DOI 10.1021/jm0495935
-
Arienti, K. L., Brunmark, A., Axe, F. U., McClure, K., Lee, A., Blevitt, J., Neff, D. K., Huang, L., Crawford, S., Pandit, C. R., Karlsson, L., and Breitenbucher, J. G. (2005) Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med. Chem. 48, 1873-1885 (Pubitemid 40396318)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.6
, pp. 1873-1885
-
-
Arienti, K.L.1
Brunmark, A.2
Axe, F.U.3
McClure, K.4
Lee, A.5
Blevitt, J.6
Neff, D.K.7
Huang, L.8
Crawford, S.9
Pandit, C.R.10
Karlsson, L.11
Breitenbucher, J.G.12
-
34
-
-
0035951809
-
Characterization of tumor-associated Chk2 mutations
-
Wu, X., Webster, S. R., and Chen, J. (2001) Characterization of tumor-associated Chk2 mutations. J. Biol. Chem. 276, 2971-2974
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2971-2974
-
-
Wu, X.1
Webster, S.R.2
Chen, J.3
-
35
-
-
36448973875
-
CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
-
DOI 10.1038/nrc2251, PII NRC2251
-
Antoni, L., Sodha, N., Collins, I., and Garrett, M. D. (2007) CHK2 kinase: cancer susceptibility and cancer therapy-two sides of the same coin? Nat. Rev. Cancer 7, 925-936 (Pubitemid 350165855)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.12
, pp. 925-936
-
-
Antoni, L.1
Sodha, N.2
Collins, I.3
Garrett, M.D.4
-
36
-
-
33847270257
-
WAF1/CIP1 in Breast cancer MCF-7 cells
-
DOI 10.1074/jbc.M606306200
-
Lee, Y. K., Thomas, S. N., Yang, A. J., and Ann, D. K. (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J. Biol. Chem. 282, 1595-1606 (Pubitemid 47076713)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.3
, pp. 1595-1606
-
-
Lee, Y.-K.1
Thomas, S.N.2
Yang, A.J.3
Ann, D.K.4
-
37
-
-
4344574540
-
Large-scale characterization of HeLa cell nuclear phosphoproteins
-
DOI 10.1073/pnas.0404720101
-
Beausoleil, S. A., Jedrychowski, M., Schwartz, D., Elias, J. E., Villén, J., Li, J., Cohn, M. A., Cantley, L. C., and Gygi, S. P. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 101, 12130-12135 (Pubitemid 39145408)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.33
, pp. 12130-12135
-
-
Beausoleil, S.A.1
Jedrychowski, M.2
Schwartz, D.3
Elias, J.E.4
Villen, J.5
Li, J.6
Cohn, M.A.7
Cantley, L.C.8
Gygi, S.P.9
-
38
-
-
84855341201
-
BRCA1 forms a functional complex with γ-H2AX as a late response to genotoxic stress
-
pii: 801594
-
Krum, S. A., la Rosa Dalugdugan, E., Miranda-Carboni, G. A., and Lane, T. F. (2010) BRCA1 forms a functional complex with γ-H2AX as a late response to genotoxic stress. J. Nucleic Acids 2010, pii: 801594
-
(2010)
J. Nucleic Acids
, vol.2010
-
-
Krum, S.A.1
La Rosa Dalugdugan, E.2
Miranda-Carboni, G.A.3
Lane, T.F.4
-
39
-
-
33846194613
-
KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions
-
DOI 10.1158/0008-5472.CAN-06-4138
-
White, D. E., Negorev, D., Peng, H., Ivanov, A. V., Maul, G. G., and Rauscher, F. J., 3rd (2006) KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 66, 11594-11599 (Pubitemid 46094169)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11594-11599
-
-
White, D.E.1
Negorev, D.2
Peng, H.3
Ivanov, A.V.4
Maul, G.G.5
Rauscher III, F.J.6
-
40
-
-
77954065271
-
I-TASSER: A unified platform for automated protein structure and function prediction
-
Roy, A., Kucukural, A., and Zhang, Y. (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat. Protoc. 5, 725-738
-
(2010)
Nat. Protoc.
, vol.5
, pp. 725-738
-
-
Roy, A.1
Kucukural, A.2
Zhang, Y.3
-
41
-
-
67349221185
-
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
-
Tian, C., Xing, G., Xie, P., Lu, K., Nie, J., Wang, J., Li, L., Gao, M., Zhang, L., and He, F. (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol. 11, 580-591
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 580-591
-
-
Tian, C.1
Xing, G.2
Xie, P.3
Lu, K.4
Nie, J.5
Wang, J.6
Li, L.7
Gao, M.8
Zhang, L.9
He, F.10
-
42
-
-
78650081714
-
ZNF274 recruits the histone methyltransferase SETDB1 to the 3′ ends of ZNF genes
-
Frietze, S., O'Geen, H., Blahnik, K. R., Jin, V. X., and Farnham, P. J. (2010) ZNF274 recruits the histone methyltransferase SETDB1 to the 3′ ends of ZNF genes. PLoS One 5, e15082
-
(2010)
PLoS One
, vol.5
-
-
Frietze, S.1
O'Geen, H.2
Blahnik, K.R.3
Jin, V.X.4
Farnham, P.J.5
-
43
-
-
0035136902
-
Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein
-
DOI 10.1128/MCB.21.3.928-939.2001
-
Gebelein, B., and Urrutia, R. (2001) Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein. Mol. Cell. Biol. 21, 928-939 (Pubitemid 32104740)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.3
, pp. 928-939
-
-
Gebelein, B.1
Urrutia, R.2
-
44
-
-
85006277004
-
Direct coupling of the cell cycle and cell death machinery by E2F
-
DOI 10.1038/ncb868
-
Nahle, Z., Polakoff, J., Davuluri, R. V., McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D., and Lowe, S. W. (2002) Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol. 4, 859-864 (Pubitemid 35331360)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.11
, pp. 859-864
-
-
Nahle, Z.1
Polakoff, J.2
Davuluri, R.V.3
McCurrach, M.E.4
Jacobson, M.D.5
Narita, M.6
Zhang, M.Q.7
Lazebnik, Y.8
Bar-Sagi, D.9
Lowe, S.W.10
-
45
-
-
33744982924
-
ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene
-
Kherrouche, Z., Blais, A., Ferreira, E., De Launoit, Y., and Monté, D. (2006) ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene. Biochem. J. 396, 547-556
-
(2006)
Biochem. J.
, vol.396
, pp. 547-556
-
-
Kherrouche, Z.1
Blais, A.2
Ferreira, E.3
De Launoit, Y.4
Monté, D.5
-
46
-
-
0033666776
-
Role of the p53-homologue p73 in E2F1-induced apoptosis
-
Stiewe, T., and Pützer, B. M. (2000) Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat. Genet. 26, 464-469
-
(2000)
Nat. Genet.
, vol.26
, pp. 464-469
-
-
Stiewe, T.1
Pützer, B.M.2
-
47
-
-
27644556419
-
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
-
DOI 10.1073/pnas.0505585102
-
Zhao, Y., Tan, J., Zhuang, L., Jiang, X., Liu, E. T., and Yu, Q. (2005) Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc. Natl. Acad. Sci. U.S.A. 102, 16090-16095 (Pubitemid 41552872)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.44
, pp. 16090-16095
-
-
Zhao, Y.1
Tan, J.2
Zhuang, L.3
Jiang, X.4
Liu, E.T.5
Yu, Q.6
-
48
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
DOI 10.1038/ncb1468, PII NCB1468
-
Wang, C., Chen, L., Hou, X., Li, Z., Kabra, N., Ma, Y., Nemoto, S., Finkel, T., Gu, W., Cress, W. D., and Chen, J. (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8, 1025-1031 (Pubitemid 44314735)
-
(2006)
Nature Cell Biology
, vol.8
, Issue.9
, pp. 1025-1031
-
-
Wang, C.1
Chen, L.2
Hou, X.3
Li, Z.4
Kabra, N.5
Ma, Y.6
Nemoto, S.7
Finkel, T.8
Gu, W.9
Cress, W.D.10
Chen, J.11
-
49
-
-
0038142184
-
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
-
DOI 10.1038/ncb998
-
Pediconi, N., Ianari, A., Costanzo, A., Belloni, L., Gallo, R., Cimino, L., Porcellini, A., Screpanti, I., Balsano, C., Alesse, E., Gulino, A., and Levrero, M. (2003) Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat. Cell Biol. 5, 552-558 (Pubitemid 36781090)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.6
, pp. 552-558
-
-
Pediconi, N.1
Ianari, A.2
Costanzo, A.3
Belloni, L.4
Gallo, R.5
Cimino, L.6
Porcellini, A.7
Screpanti, I.8
Balsano, C.9
Alesse, E.10
Gulino, A.11
Levrero, M.12
-
50
-
-
0042632901
-
Pathways of DNA double-strand break repair during the mammalian cell cycle
-
DOI 10.1128/MCB.23.16.5706-5715.2003
-
Rothkamm, K., Krüger, I., Thompson, L. H., and Löbrich, M. (2003) Pathways ofDNAdouble-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23, 5706-5715 (Pubitemid 36951334)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.16
, pp. 5706-5715
-
-
Rothkamm, K.1
Kruger, I.2
Thompson, L.H.3
Lobrich, M.4
-
51
-
-
77953166592
-
γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
-
Löbrich, M., Shibata, A., Beucher, A., Fisher, A., Ensminger, M., Goodarzi, A. A., Barton, O., and Jeggo, P. A. (2010) γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle 9, 662-669
-
(2010)
Cell Cycle
, vol.9
, pp. 662-669
-
-
Löbrich, M.1
Shibata, A.2
Beucher, A.3
Fisher, A.4
Ensminger, M.5
Goodarzi, A.A.6
Barton, O.7
Jeggo, P.A.8
-
52
-
-
4944234150
-
Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
-
DOI 10.1158/0008-5472.CAN-04-1433
-
Banáth, J. P., Macphail, S. H., and Olive, P. L. (2004) Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res. 64, 7144-7149 (Pubitemid 39331029)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7144-7149
-
-
Banath, J.P.1
MacPhail, S.H.2
Olive, P.L.3
-
53
-
-
79960677839
-
KAP1 protein: An enigmatic master regulator of the genome
-
Iyengar, S., and Farnham, P. J. (2011) KAP1 protein: an enigmatic master regulator of the genome. J. Biol. Chem. 286, 26267-26276
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 26267-26276
-
-
Iyengar, S.1
Farnham, P.J.2
-
54
-
-
34347353316
-
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
-
O'Geen, H., Squazzo, S. L., Iyengar, S., Blahnik, K., Rinn, J. L., Chang, H. Y., Green, R., and Farnham, P. J. (2007) Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet. 3, e89
-
(2007)
PLoS Genet.
, vol.3
-
-
O'Geen, H.1
Squazzo, S.L.2
Iyengar, S.3
Blahnik, K.4
Rinn, J.L.5
Chang, H.Y.6
Green, R.7
Farnham, P.J.8
-
56
-
-
0035878122
-
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
-
Lin, W. C., Lin, F. T., and Nevins, J. R. (2001) Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 15, 1833-1844
-
(2001)
Genes Dev.
, vol.15
, pp. 1833-1844
-
-
Lin, W.C.1
Lin, F.T.2
Nevins, J.R.3
|