Spontaneous mutation of the Dock2 gene in Irf5 -/- mice complicates interpretation of type I interferon production and antibody responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages

  Purtha, Whitney E ^a   Swiecki, Melissa ^a   Colonna, Marco ^a   Diamond, Michael S ^a   Bhattacharya, Deepta ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity viruses; Immune cell development

Indexed keywords

INTERFERON;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DEDICATOR OF CYTOKINESIS 2 GENE; DENDRITIC CELL; GENE; GENE EXPRESSION; GENE MUTATION; HOMOZYGOSITY; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PHENOTYPE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BASE SEQUENCE; CHROMOSOMES, MAMMALIAN; CROSSES, GENETIC; DENDRITIC CELLS; FEMALE; GENE DUPLICATION; GENETIC LOCI; GTPASE-ACTIVATING PROTEINS; HUMANS; INTERFERON REGULATORY FACTORS; INTERFERON TYPE I; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE;

MUS;

EID: 84859612798     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118155109     Document Type: Article

References (30)

1. Barnes BJ, Moore PA, Pitha PM (2001) Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem 276:23382-23390.
2. Takaoka A, et al. (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-249. (Pubitemid 40388058)
3. Savitsky D, Tamura T, Yanai H, Taniguchi T (2010) Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 59: 489-510.
4. Miceli-Richard C, et al. (2007) Association of an IRF5 gene functional polymorphism with Sjögren's syndrome. Arthritis Rheum 56:3989-3994. (Pubitemid 350262326)
5. Graham RR, et al.; Argentine and Spanish Collaborative Groups (2006) A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 38: 550-555.
6. Kristjansdottir G, et al. (2008) Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet 45: 362-369. (Pubitemid 351839477)
7. Sigurdsson S, et al. (2007) Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum 56: 2202-2210. (Pubitemid 47173567)
8. Dideberg V, et al. (2007) An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet 16:3008-3016. (Pubitemid 350131319)
9. Burman P, Karlsson FA, Oberg K, Alm G (1985) Autoimmune thyroid disease in interferon-treated patients. Lancet 2:100-101. (Pubitemid 15047529)
10. Cella M, et al. (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919-923. (Pubitemid 29372419)
11. Yanai H, et al. (2007) Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci USA 104:3402-3407. (Pubitemid 46364171)
12. Yasuda K, et al. (2007) Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol 178:6876-6885. (Pubitemid 46847413)
13. Gratz N, et al. (2011) Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection. PLoS Pathog 7: e1001345.
14. Dai P, et al. (2011) Myxoma virus induces type I IFN production in murine plasmacytoid dendritic cells via a TLR9/MyD88, IRF5/IRF7, and IFNAR-dependent pathway. J Virol 85: 10814-10825.
15. Savitsky DA, Yanai H, Tamura T, Taniguchi T, Honda K (2010) Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci USA 107:10154-10159.
16. Lien C, et al. (2010) Critical role of IRF-5 in regulation of B-cell differentiation. Proc Natl Acad Sci USA 107:4664-4668.
17. Fukui Y, et al. (2001) Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412:826-831. (Pubitemid 32801465)
18. Gotoh K, et al. (2010) Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. J Exp Med 207: 721-730.
19. Gotoh K, et al. (2008) Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells. Blood 111:2973-2976.
20. Liu K, et al. (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324:392-397.
21. Onai N, et al. (2007) Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 8:1207-1216. (Pubitemid 350011759)
22. Suzuki S, et al. (2004) Critical roles of interferon regulatory factor 4 in CD11b high CD8alpha- dendritic cell development. Proc Natl Acad Sci USA 101:8981-8986. (Pubitemid 38781597)
23. Schiavoni G, et al. (2002) ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med 196:1415-1425. (Pubitemid 35424936)
24. Allman D, et al. (2001) Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 167:6834-6840. (Pubitemid 33144175)
25. Asselin-Paturel C, Brizard G, Pin J-J, Brière F, Trinchieri G (2003) Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 171:6466-6477. (Pubitemid 37532075)
26. Chang Y-F, Imam JS, Wilkinson MF (2007) The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76:51-74.
27. Oliphant T, et al. (2007) Induction of epitope-specific neutralizing antibodies against West Nile virus. J Virol 81:11828-11839. (Pubitemid 47623815)
28. Bhattacharya D, Logue EC, Bakkour S, DeGregori J, Sha WC (2002) Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci USA 99:8838-8843. (Pubitemid 34693645)
29. Ranganath S, et al. (1998) GATA-3-dependent enhancer activity in IL-4 gene regulation. J Immunol 161:3822-3826. (Pubitemid 28468954)
30. Bhattacharya D, Lee DU, Sha WC (2002) Regulation of Ig class switch recombination by NF-kappaB: Retroviral expression of RelB in activated B cells inhibits switching to IgG1, but not to IgE. Int Immunol 14:983-991.