Risk assessment in skin gene therapy: Viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors

Gene Therapy

Volumn 18, Issue 7, 2011, Pages 674-681

  Almarza, D ^a   Bussadori, G ^b   Navarro, M ^a   Mavilio, F ^b   Larcher, F ^a   Murillas, R ^a  

^a CIEMAT   (Spain)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

insertional mutagenesis; lentiviral vectors; read through; Skin gene therapy

Indexed keywords

LENTIVIRUS VECTOR; RETROVIRUS VECTOR; RNA;

ARTICLE; CELL CLONE; CELL FUSION; DOWN REGULATION; GENE THERAPY; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; KERATINOCYTE; MOLECULAR WEIGHT; NORTHERN BLOTTING; PRIORITY JOURNAL; PROVIRUS; RISK ASSESSMENT; SKIN GENE THERAPY; VIRUS EXPRESSION;

GENE FUSION; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; KERATIN-14; KERATINOCYTES; LENTIVIRUS; PROVIRUSES; RISK ASSESSMENT; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; VIRUS INACTIVATION; VIRUS INTEGRATION;

EID: 79960110370     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.12     Document Type: Article

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