Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma

Cancer Science

Volumn 103, Issue 6, 2012, Pages 984-992

  Liao, Rui ^a   Sun, Tai Wei ^a   Yi, Yong ^a   Wu, Han ^a   Li, Yi Wei ^a   Wang, Jia Xing ^a   Zhou, Jian ^a   Shi, Ying Hong ^a   Cheng, Yun Feng ^a   Qiu, Shuang Jian ^a,b   Fan, Jia ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI CANCER INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ADULT; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURGERY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; TISSUE MICROARRAY;

CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; FEMALE; HEPATIC STELLATE CELLS; HEPATITIS B; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; INFLAMMATION; INTERLEUKIN-6; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYELOID CELLS; MYOFIBROBLASTS; PROGNOSIS; RECEPTORS, IMMUNOLOGIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861701249     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02273.x     Document Type: Article

References (47)

1. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6: 392-401.
2. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-7.
3. Erez N, Truitt M, Olson P et al. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010; 17: 135-47.
4. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141: 39-51.
5. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006; 6: 674-87.
6. Ju MJ, Qiu SJ, Fan J et al. Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection. Am J Clin Pathol 2009; 131: 498-510.
7. Zhu XD, Zhang JB, Zhuang PY et al. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol 2008; 26: 2707-16.
8. Li YW, Qiu SJ, Fan J et al. Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol 2011; 54: 497-505.
9. Ju MJ, Qiu SJ, Gao Q et al. Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma. Cancer Sci 2009; 100: 1267-74.
10. Budhu A, Forgues M, Ye QH et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 2006; 10: 99-111.
11. Zhou H, Huang H, Shi J et al. Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resection. Gut 2010; 59: 1699-708.
12. Nakagawa H, Maeda S, Yoshida H et al. Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int J Cancer 2009; 125: 2264-9.
13. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88: 125-72.
14. Amann T, Bataille F, Spruss T et al. Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma. Cancer Sci 2009; 100: 646-53.
15. Sancho-Bru P, Juez E, Moreno M et al. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int 2010; 30: 31-41.
16. Mikula M, Proell V, Fischer AN et al. Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 2006; 209: 560-7.
17. Neaud V, Faouzi S, Guirouilh J et al. Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor. Hepatology 1997; 26: 1458-66.
18. Kang N, Gores G, Shah V. Hepatic stellate cells: Partners in crime for liver metastases? Hepatology 2011; 54: 707-13.
19. Olaso E, Salado C, Egilegor E et al. Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis. Hepatology 2003; 37: 674-85.
20. Matsusue R, Kubo H, Hisamori S et al. Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. Ann Surg Oncol 2009; 16: 2645-53.
21. Tessarz AS, Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett 2008; 116: 111-6.
22. Bouchon A, Facchetti F, Weigand MA et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001; 410: 1103-7.
23. Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009; 21: 38-46.
24. Dower K, Ellis DK, Saraf K et al. Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide. J Immunol 2008; 180: 3520-34.
25. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003; 3: 445-53.
26. Bosco MC, Pierobon D, Blengio F et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mDCs: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood 2010; 117: 2625-39.
27. Ho CC, Liao WY, Wang CY et al. TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am J Respir Crit Care Med 2008; 177: 763-70.
28. Paik YH, Schwabe RF, Bataller R et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003; 37: 1043-55.
29. Isayama F, Hines IN, Kremer M et al. LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1318-28.
30. Brun P, Castagliuolo I, Pinzani M et al. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2005; 289: G571-8.
31. Sharif O, Knapp S. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 2008; 213: 701-13.
32. Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71-8.
33. Liu X, Liang J, Li G. Lipopolysaccharide promotes adhesion and invasion of hepatoma cell lines HepG2 and HepG2.2.15. Mol Biol Rep 2010; 37: 2235-9.
34. Sancho-Bru P, Bataller R, Gasull X et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005; 43: 272-82.
35. Gibot S, Kolopp-Sarda MN, Bene MC et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 2004; 200: 1419-26.
36. Xu YF, Yi Y, Qiu SJ et al. PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. J Hepatol 2010; 53: 872-9.
37. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883-99.
38. Ninomiya K, Takahashi A, Fujioka Y et al. Transforming growth factor-beta signaling enhances transdifferentiation of macrophages into smooth muscle-like cells. Hypertens Res 2006; 29: 269-76.
39. Chen LC, Laskin JD, Gordon MK et al. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol 2008; 84: 145-55.
40. Mabuchi A, Mullaney I, Sheard PW et al. Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. J Hepatol 2004; 40: 910-6.
41. Giamarellos-Bourboulis EJ, Zakynthinos S, Baziaka F et al. Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. Intensive Care Med 2006; 32: 237-43.
42. Schenk M, Bouchon A, Seibold F et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 2007; 117: 3097-106.
43. Gibot S, Massin F, Alauzet C et al. Effects of the TREM 1 pathway modulation during hemorrhagic shock in rats. Shock 2009; 32: 633-7.
44. Mantovani A. Cancer: Inflaming metastasis. Nature 2009; 457: 36-7.
45. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904.
46. Haabeth OA, Lorvik KB, Hammarstrom C et al. Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nat Commun 2011; 2: 240.
47. Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 2007; 117: 1175-83.