The TREM-1/DAP12 pathway

Immunology Letters

Volumn 116, Issue 2, 2008, Pages 111-116

  Tessarz, Anja S ^a   Cerwenka, Adelheid ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

DAP12; Myeloid cells; Signal transduction; TREM 1

Indexed keywords

CHEMOKINE; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; METALLOPROTEINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

BONE MARROW CELL; CELL SURFACE; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GENE EXPRESSION; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MONOCYTES; NEUTROPHILS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 40149105559     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.11.021     Document Type: Review

References (55)

1. Kawamoto H., and Minato N. Myeloid cells. Int J Biochem Cell Biol 36 (2004) 1374-1379
2. Fu H., Karlsson J., Bylund J., Movitz C., Karlsson A., and Dahlgren C. Ligand recognition and activation of formyl peptide receptors in neutrophils. J Leukoc Biol 79 (2006) 247-256
3. Daeron M. Fc receptor biology. Annu Rev Immunol 15 (1997) 203-234
4. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu Rev Immunol 21 (2003) 335-376
5. Bakker A.B., Baker E., Sutherland G.R., Phillips J.H., and Lanier L.L. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci USA 96 (1999) 9792-9796
6. Bouchon A., Dietrich J., and Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 164 (2000) 4991-4995
7. Cambier J.C. New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL). Immunol Today 16 (1995) 110
8. Reth M. Antigen receptor tail clue. Nature 338 (1989) 383-384
9. Daeron M., Latour S., Malbec O., Espinosa E., Pina P., Pasmans S., et al. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 3 (1995) 635-646
10. Tomasello E., Olcese L., Vely F., Geourgeon C., Blery M., Moqrich A., et al. Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J Biol Chem 273 (1998) 34115-34119
11. Turnbull I.R., and Colonna M. Activating and inhibitory functions of DAP12. Nat Rev Immunol 7 (2007) 155-161
12. Maeda A., Kurosaki M., and Kurosaki T. Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptor gamma chain. J Exp Med 188 (1998) 991-995
13. Cosman D., Fanger N., Borges L., Kubin M., Chin W., Peterson L., et al. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7 (1997) 273-282
14. Kanazawa N., Tashiro K., Inaba K., and Miyachi Y. Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain. J Biol Chem 278 (2003) 32645-32652
15. Merck E., Gaillard C., Gorman D.M., Montero-Julian F., Durand I., Zurawski S.M., et al. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Blood 104 (2004) 1386-1395
16. Tomasello E., Cant C., Buhring H.J., Vely F., Andre P., Seiffert M., et al. Association of signal-regulatory proteins beta with KARAP/DAP-12. Eur J Immunol 30 (2000) 2147-2156
17. Shiratori I., Ogasawara K., Saito T., Lanier L.L., and Arase H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med 199 (2004) 525-533
18. Aguilar H., Alvarez-Errico D., Garcia-Montero A.C., Orfao A., Sayos J., and Lopez-Botet M. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J Immunol 173 (2004) 6703-6711
19. Wright G.J., Cherwinski H., Foster-Cuevas M., Brooke G., Puklavec M.J., Bigler M., et al. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol 171 (2003) 3034-3046
20. Yotsumoto K., Okoshi Y., Shibuya K., Yamazaki S., Tahara-Hanaoka S., Honda S., et al. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med 198 (2003) 223-233
21. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 3 (2003) 445-453
22. Klesney-Tait J., Turnbull I.R., and Colonna M. The TREM receptor family and signal integration. Nat Immunol 7 (2006) 1266-1273
23. Bouchon A., Facchetti F., Weigand M.A., and Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410 (2001) 1103-1107
24. Hamerman J.A., Jarjoura J.R., Humphrey M.B., Nakamura M.C., Seaman W.E., and Lanier L.L. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 177 (2006) 2051-2055
25. Vitale M., Bottino C., Sivori S., Sanseverino L., Castriconi R., Marcenaro E., et al. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J Exp Med 187 (1998) 2065-2072
26. Allcock R.J., Barrow A.D., Forbes S., Beck S., and Trowsdale J. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol 33 (2003) 567-577
27. Viertlboeck B.C., Schmitt R., and Gobel T.W. The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L. Immunogenetics 58 (2006) 180-190
28. Ramanathan B., Minton J.E., Ross C.R., and Blecha F. Characterization of bovine cDNA encoding triggering receptor expressed on myeloid cells 1 (TREM-1). Vet Immunol Immunopathol 102 (2004) 85-89
29. Cannon J.P., Haire R.N., Mueller M.G., Litman R.T., Eason D.D., Tinnemore D., et al. Ancient divergence of a complex family of immune-type receptor genes. Immunogenetics 58 (2006) 362-373
30. Stet R.J., Hermsen T., Westphal A.H., Jukes J., Engelsma M., Lidy Verburg-van Kemenade B.M., et al. Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44. Immunogenetics 57 (2005) 77-89
31. Kelker M.S., Foss T.R., Peti W., Teyton L., Kelly J.W., Wuthrich K., et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. J Mol Biol 342 (2004) 1237-1248
32. Radaev S., Kattah M., Rostro B., Colonna M., and Sun P.D. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure 11 (2003) 1527-1535
33. Kelker M.S., Debler E.W., and Wilson I.A. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. J Mol Biol 344 (2004) 1175-1181
34. Gingras M.C., Lapillonne H., and Margolin J.F. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol 38 (2002) 817-824
35. Gomez-Pina V., Soares-Schanoski A., Rodriguez-Rojas A., Del Fresno C., Garcia F., Vallejo-Cremades M.T., et al. Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol 179 (2007) 4065-4073
36. Schenk M., Bouchon A., Seibold F., and Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest (2007)
37. Bleharski J.R., Kiessler V., Buonsanti C., Sieling P.A., Stenger S., Colonna M., et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol 170 (2003) 3812-3818
38. Murakami Y., Kohsaka H., Kitasato H., and Akahoshi T. Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2. J Immunol 178 (2007) 1144-1150
39. Zeng H., Ornatowska M., Joo M.S., and Sadikot R.T. TREM-1 expression in macrophages is regulated at transcriptional level by NF-kappaB and PU. 1. Eur J Immunol 37 (2007) 2300-2308
40. Gibot S., Buonsanti C., Massin F., Romano M., Kolopp-Sarda M.N., Benigni F., et al. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Infect Immun 74 (2006) 2823-2830
41. El Mezayen R., El Gazzar M., Seeds M.C., McCall C.E., Dreskin S.C., and Nicolls M.R. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett 111 (2007) 36-44
42. Colonna M., and Facchetti F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis 187 Suppl 2 (2003) S397-S401
43. Haselmayer P., Grosse-Hovest L., von Landenberg P., Schild H., and Radsak M.P. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 110 (2007) 1029-1035
44. Mohamadzadeh M., Coberley S.S., Olinger G.G., Kalina W.V., Ruthel G., Fuller C.L., et al. Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses. J Virol 80 (2006) 7235-7244
45. Tessarz A.S., Weiler S., Zanzinger K., Angelisova P., Horejsi V., and Cerwenka A. Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells. J Immunol 178 (2007) 1991-1999
46. Janssen E., Zhu M., Zhang W., and Koonpaew S. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol 4 (2003) 117-123
47. Brdicka T., Imrich M., Angelisova P., Brdickova N., Horvath O., Spicka J., et al. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med 196 (2002) 1617-1626
48. Gibot S., Kolopp-Sarda M.N., Bene M.C., Bollaert P.E., Lozniewski A., Mory F., et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 200 (2004) 1419-1426
49. Hara H., Ishihara C., Takeuchi A., Imanishi T., Xue L., Morris S.W., et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol 8 (2007) 619-629
50. Thome M., and Weil R. Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol 28 (2007) 281-288
51. Ornatowska M., Azim A.C., Wang X., Christman J.W., Xiao L., Joo M., et al. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol 293 (2007) L1377-L1384
52. Netea M.G., Azam T., Ferwerda G., Girardin S.E., Kim S.H., and Dinarello C.A. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol 80 (2006) 1454-1461
53. Fortin C.F., Lesur O., and Fulop Jr. T. Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int Immunol 19 (2007) 41-50
54. Akira S., Yamamoto M., and Takeda K. Role of adapters in Toll-like receptor signalling. Biochem Soc Trans 31 (2003) 637-642
55. Radsak M.P., Salih H.R., Rammensee H.G., and Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol 172 (2004) 4956-4963