Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Rodriguez Franco, Eillen J ^a   Cantres Rosario, Yisel M ^a   Plaud Valentin, Marines ^a   Romeu, Rafael ^b   Rodríguez, Yolanda ^a   Skolasky, Richard ^d   Meléndez, Viviana ^b,c   Cadilla, Carmen L ^a   Melendez, Loyda M ^a  

^a UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^c UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CYSTATIN B; CYSTATIN C; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE;

ADULT; APOPTOSIS; ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN TISSUE; CANCER CELL CULTURE; CELL TYPE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IMMUNOREACTIVITY; IN VIVO STUDY; INCUBATION TIME; LYSOSOME; MACROPHAGE; MONOCYTE; NERVE CELL; NEUROTOXICITY; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN SECRETION; SUPERNATANT; UPREGULATION; COGNITION; CYTOLOGY; DRUG ANTAGONISM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); TUMOR CELL LINE; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

APOPTOSIS; BASAL GANGLIA; CATHEPSIN B; CELL LINE, TUMOR; COGNITION; CYSTATIN B; CYSTATIN C; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; HIV-1; HUMANS; INTRACELLULAR SPACE; LYSOSOMES; MACROPHAGES; MONOCYTES; NEURONS;

EID: 84861663912     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036571     Document Type: Article

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