Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation

Virology

Volumn 320, Issue 2, 2004, Pages 301-312

  Kaznelson, Dorte Wissing ^a   Bruun, Silas ^a   Monrad, Astrid ^a   Gjerløv, Simon ^a   Birk, Jesper ^b   Röpke, Carsten ^c   Norrild, Bodil ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Apoptosis; Cathepsin B; Human papilloma virus

Indexed keywords

CATHEPSIN B; PROTEIN E7; PROTEIN P21;

APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL LINE; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN CELL; MODEL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS TYPING; WART VIRUS;

APOPTOSIS; CATHEPSIN B; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME ACTIVATION; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; TRANSGENES;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS;

EID: 1542285418     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2003.12.018     Document Type: Article

References (47)

1. Adjei P.N., Kaufmann S.H., Leung W.Y., Mao F., Gores G.J. Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32. J. Clin. Invest. 98:1996;2588-2596.
2. Basile J.R., Zacny V., Munger K. The cytokines tumor necrosis factor-alpha (TNF-alpha) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein. J. Biol. Chem. 276(25):2001;22522-22528. (June 22).
3. Chan S.J., San Segundo B., McCormick M.B., Steiner D.F. Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc. Natl. Acad. Sci. U.S.A. 83:1986;7721-7725.
4. Chang H.Y., Yang X. Proteases for cell suicide: functions and regulation of caspases. Microbiol. Mol. Biol. Rev. 64:2000;821-846.
5. Deiss L.P., Galinka H., Berissi H., Cohen O., Kimchi A. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 15:1996;3861-3870.
6. Doerfler P., Forbush K.A., Perlmutter R.M. Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol. 164:2000;4071-4079.
7. Eck-Enriquez K., Kiefer T.L., Spriggs L.L., Hill S.M. Pathways through which a regimen of melatonin and retinoic acid induces apoptosis in MCF-7 human breast cancer cells. Breast Cancer Res. Treat. 61:2000;229-239.
8. Erickson A.H. Biosynthesis of lysosomal endopeptidases. J. Cell. Biochem. 40:1989;31-41.
9. Finzer P., Kuntzen C., Soto U., Zur H.H., Rosl F. Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression. Oncogene. 20(35):2001;4768-4776. (Aug. 9).
10. Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., Elling F., Leist M., Jaattela M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J. Cell Biol. 153:2001;999-1010.
11. Funk J.O., Waga S., Harry J.B., Espling E., Stillman B., Galloway D.A. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:1997;2090-2100.
12. Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., Kaufmann S.H., Gores G.J. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 106:2000;1127-1137.
13. Hickman E.S., Bates S., Vousden K.H. Perturbation of the p53 response by human papillomavirus type 16 E7. J. Virol. 71:1997;3710-3718.
14. Jaattela M., Mouritzen H., Elling F., Bastholm L. A20 zinc finger protein inhibits TNF and IL-1 signaling. J. Immunol. 156:1996;1166-1173.
15. Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273:1998;9357-9360.
16. Jian Y.D.C., Chien W.M., Wu X., Broker T.R., Chow L.T. Post-transcriptional induction of p21cip1 protein by human papillomavirus E7 inhibits unscheduled DNA synthesis reactivated in differentiated keratinocytes. Oncogene. 17:1998;2027-2038.
17. Jian Y., Van Tine B.A., Chien W.M., Shaw G.M., Broker T.R., Chow L.T. Concordant induction of cyclin E and p21cip1 in differentiated keratinocytes by the human papillomavirus E7 protein inhibits cellular and viral DNA synthesis. Cell Growth Differ. 10:1999;101-111.
18. Jones D.L., Thompson D.A., Suh-Burgmann E., Grace M., Munger K. Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway. Virology. 258:1999;406-414.
19. Lee J.E., Kim C.Y., Giaccia A.J., Giffard R.G. The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury. Brain Res. 795:1998;10-16.
20. Leist M., Jaattela M. Triggering of apoptosis by cathepsins. Cell Death Differ. 8:2001;324-326.
21. Liang Y., Yan C., Schor N.F. Apoptosis in the absence of caspase 3. Oncogene. 20:2001;6570-6578.
22. Liu Y., McKalip A., Herman B. Human papillomavirus type 16 E6 and HPV-16 E6/E7 sensitize human keratinocytes to apoptosis induced by chemotherapeutic agents: roles of p53 and caspase activation. J. Cell. Biochem. 78(2):2000;334-349. (May).
23. MacKenzie J.R., Mason S.L., Hickford J.G., Kohonen-Corish M.R., Bickerstaffe R. A polymorphic marker for the human cathepsin B gene. Mol. Cell. Probes. 15:2001;235-237.
24. Mathiasen I.S., Hansen C.M., Foghsgaard L., Jaattela M. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. Int. J. Cancer. 93:2001;224-231.
25. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:1990;3587-3596.
26. Nahle Z., Polakoff J., Davuluri R.V., McCurrach M.E., Jacobson M.D., Narita M., Zhang M.Q., Lazebnik Y., Bar-Sagi D., Lowe S.W. Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell Biol. 4(11):2002;859-864. (Nov.).
27. Pan H., Griep A.E. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1994;1285-1299.
28. Park J.S., Boyer S., Mitchell K., Gilfor D., Birrer M., Darlington G., El Deiry W., Firestone G.L., Munger K., Band V., Fisher P.B., Dent P. Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6). J. Biol. Chem. 275:2000;18-28.
29. Polgar L., Csoma C. Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B. J. Biol. Chem. 262:1987;14448-14453.
30. Porter A.G., Janicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:1999;99-104.
31. Puthenveettil J.A., Frederickson S.M., Reznikoff C.A. Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells. Oncogene. 13:1996;1123-1131.
32. Roberts L.R., Adjei P.N., Gores G.J. Cathepsins as effector proteases in hepatocyte apoptosis. Cell Biochem. Biophys. 30:1999;71-88.
33. Ruggiero V., Johnson S.E., Baglioni C. Protection from tumor necrosis factor cytotoxicity by protease inhibitors. Cell. Immunol. 107:1987;317-325.
34. Schmitt C.A., Lowe S.W. Apoptosis and therapy. J. Pathol. 187:1999;127-137.
35. Soengas M.S., Capodieci P., Polsky D., Mora J., Esteller M., Opitz-Araya X., McCombie R., Herman J.G., Gerald W.L., Lazebnik Y.A., Cordon-Cardo C., Lowe S.W. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature. 409:2001;207-211.
36. Stoka V., Turk B., Schendel S.L., Kim T.H., Cirman T., Snipas S.J., Ellerby L.M., Bredesen D., Freeze H., Abrahamson M., Bromme D., Krajewski S., Reed J.C., Yin X.M., Turk V., Salvesen G.S. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J. Biol. Chem. 276:2001;3149-3157.
37. Stoppler H., Stoppler M.C., Johnson E., Simbulan-Rosenthal C.M., Smulson M.E., Iyer S., Rosenthal D.S., Schlegel R. The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis. Oncogene. 17:1998;1207-1214.
38. Suzuki A., Tsutomi Y., Akahane K., Araki T., Miura M. Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP. Oncogene. 17:1998;931-939.
39. Suzuki A., Tsutomi Y., Miura M., Akahane K. Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21. Oncogene. 18:1999;1239-1244.
40. Suzuki A., Ito T., Kawano H., Hayashida M., Hayasaki Y., Tsutomi Y., Akahane K., Nakano T., Miura M., Shiraki K. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene. 19:2000;1346-1353.
41. Thompson D.A., Zacny V., Belinsky G.S., Classon M., Jones D.L., Schlegel R., Munger K. The HPV E7 oncoprotein inhibits tumor necrosis factor alpha-mediated apoptosis in normal human fibroblasts. Oncogene. 20:2001;3629-3640.
42. Thullberg M., Welcker M., Bartkova J., Kjerulff A.A., Lukas J., Hogberg J., Bartek J. Monoclonal antibody probes for p21WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors. Hybridoma. 19:2000;63-72.
43. Tommasino M., Adamczewski J.P., Carlotti F., Barth C.F., Manetti R., Contorni M., Cavalieri F., Hunt T., Crawford L. HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A. Oncogene. 8:1993;195-202.
44. Tsao Y.P., Huang S.J., Chang J.L., Hsieh J.T., Pong R.C., Chen S.L. Adenovirus-mediated p21((WAF1/SDII/CIP1)) gene transfer induces apoptosis of human cervical cancer cell lines. J. Virol. 73:1999;4983-4990.
45. Tsujimoto Y., Croce C.M. Molecular cloning of a human immunoglobulin lambda chain variable sequence. Nucleic Acids Res. 12:1984;8407-8414.
46. Vanags D.M.M.I., Coppola S., Burgess D.H., Orrenius S. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J. Biol. Chem. 271:1996;31075-31085.
47. Wright S.C., Wei Q.S., Zhong J., Zheng H., Kinder D.H., Larrick J.W. Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation. J. Exp. Med. 180:1994;2113-2123.