A particle-receptor model for the insulin-induced closure of connexin43 channels

Circulation Research

Volumn 83, Issue 1, 1998, Pages 27-32

  Homma, Nobuo ^a   Alvarado, José Luis ^a   Coombs, Wanda ^c   Stergiopoulos, Kathleen ^a   Taffet, Steven M ^a   Lau, Alan F ^b   Delmar, Mario ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^c SUNY Health Science Center ^*

Author keywords

Connexin43; Gap junction conductance; Insulin; Phosphorylation; Xenopus oocyte

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN; INSULIN; ION CHANNEL; SOMATOMEDIN;

ARTICLE; CHANNEL GATING; FEMALE; GAP JUNCTION; HORMONAL REGULATION; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MODEL; OOCYTE; PH; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 0032514173     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.1.27     Document Type: Article

References (35)

1. Simon AM, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin 37. Nature. 1997;385:525-529.
2. Willecke K, Buchmann A, Butzler C, Gabriel H-D, Hagendorff A, Jung D, Kirchhoff S, Kruger O, Nelles E, Schwarz M, Temme A, Traub O, Winterhager E. Biological functions of gap junctions revealed by targeted inactivation of mouse connexin32, -26 and -40 genes. In: Werner R, ed. Gap Junctions. Amsterdam, Netherlands: IOS Press; 1998:304-308.
3. Gong XH, Li E, Klier G, Huang QL, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB. Disruption of alpha(3) connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997;91:833-843.
4. White TW, Goodenough DA, Paul DL. Ocular abnormalities in connexin50 knockout mice [abstract]. Mol Biol Cell. 1997;8:93a.
5. Reaume AG, de Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267:1831-1834.
6. Ewart JL, Cohen MF, Meyer RA, Huang GY, Wessels A, Gourdie RG, Chin AJ, Park SJ, Lazalin BO, Villabon S, Lo CW. Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene. Development. 1997;124:1281-1292.
7. Bergoffen J, Scherer SS, Wang S, Oronzi Scott M, Bone LJ, Paul DL, Chen K, Lensch MW, Chance PF, Fischbeck KH. Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science. 1993;262:2039-2042.
8. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 1996;238:1-27.
9. Kelsell DP, Dunlop J, Stevens HP, Lench NJ, Liang JN, Parry G, Mueller RF, Leigh IM. Connexin26 mutations in hereditary non-syndromic sensorineural deafness. Nature. 1997;387:80-83.
10. Gebbia M, Towbin JA, Casey B. Failure to detect connexin43 mutations in 38 cases of sporadic and familial heterotaxy. Circulation. 1996;94:1909-1912.
11. Splitt MP, Tsai MY, Burn J, Goodship JA. Absence of mutations in the regulatory domain of the gap junction protein connexin 43 in patients with visceroatrial heterotaxy. Heart. 1997;77:369-370.
12. Britz-Cunningham SH, Shah MM, Zuppan CW, Fletcher WH. Mutations of the connexin43 gap junction gene in patients with heart malformations and defects of laterally. N Engl J Med. 1995;332:1323-1329.
13. Yeager M, Nicholson BJ. Structure of gap junction intercellular channels. Cur Opinion Struct Biol. 1996;6:183-192.
14. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem. 1996;65:475-502.
15. Liu S, Taffet S, Stoner L, Delmar M, Vallano ML, Jalife J. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length. Biophys J. 1993;64:1422-1433.
16. Morley GE, Taffet SM, Delmar M. Intramolecular interactions mediate pH regulation of connexin43 channels. Biophys J. 1996;70:1294-1302.
17. Hoshi T, Zagotta WN, Aldrich RW. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 1990;250:533-538.
18. Ek JF, Delmar M, Perzova R, Taffet SM. Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43. Circ Res. 1994; 74:1058-1064.
19. Spray DC, Harris AL, Bennett MVL. Equilibrium properties of a voltage-dependent junctional conductance. J Gen Physiol. 1981;77:77-93.
20. White TW, Paul DL, Goodenough DA, Bruzzone R. Functional analysis of selective interactions among rodent connexins. Mol Biol Cell. 1995;6:459-470.
21. Vandeyar MA, Weiner MP, Hutton CJ, Batt CA. A simple and rapid method for the selection of oligodeoxynucleotide-dictated mutants. Gene. 1988;65:129-133.
22. EK-Vitorin JF, Calero G, Morley GE, Coombs W, Taffet SM, Delmar M. pH regulation of connexin43: molecular analysis of the gating particle. Biophys J. 1996;71:1273-1284.
23. Chuang LM, Myers MG Jr, Seidner GA, Birnbaum MJ, White MF, Kahn CR. Insulin receptor substrate 1 mediates insulin and insulin-like growth factor 1- stimulated maturation of Xenopus oocytes. Proc Natl Acad Sci USA. 1993;90:5172-5175.
24. Janicot M, Flores-Riveros JR, Lane MD. The insulin-like growth factor 1 (IGF-1) receptor is responsible for mediating the effects of insulin, IGF-1, and IGF-2 in Xenopus laevis oocytes. J Biol Chem. 1991;266:9382-9391.
25. Lau AF, Kurata WE, Kanemitsu MY, Loo LW, Warn-Cramer BJ, Eckert W, Lampe PD. Regulation of connexin43 function by activated tyrosine protein kinase. J Bioenerg Biomembr. 1996;28:359-368.
26. Grigorescu F, Baccara MT, Rouard M, Renard E. Insulin and IGF-1 signaling in oocyte maturation. Horm Res. 1994;42:55-61.
27. Warn-Cramer BJ, Lampe PD, Kurata WE, Kanemitsu MY, Loo LW, Eckert W, Lau AF. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem. 1996;271:3779-3786.
28. Duerr RL, McKirnan MD, Gim RD, Clark RG, Chien KR, Ross J Jr. Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat. Circulation. 1996; 93:2188-2196.
29. Delafontaine P. Insulin-like growth factor-1 and its binding proteins in the cardiovascular system. Cardiovasc Res. 1995;30:825-834.
30. Stefanovic D, Erikson E, Pike LJ, Mailer JL. Activation of a ribosomal protein S6 kinase in Xenopus oocytes by insulin and insulin-receptor kinase. EMBO J. 1986;5:157-160.
31. Lau AF, Kanemitsu MY, Kurata WE, Danesh S, Boynton AL. Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. Mol Biol Cell. 1992;3:865-874.
32. Zhou L, Nicholson BJ. A "ball-and-chain" mechanism for the gating of Cx43 gap junction channels by v-src [abstract]. Mol Biol Cell. 1997;8:93a.
33. Calero G, Kanemitsu M, Taffet SM, Lau AF, Delmar M. A 17mer peptide interferes with acidification-induced uncoupling of connexin43. Circ Res. 1998;82:929-935.
34. Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res. 1996;79:647-658.
35. Spray DC, Burt JM. Structure-activity relations of the cardiac gap junction channel. Am J Physiol. 1990;258:C195-C205.