Role of gap junctions in the propagation of the cardiac action potential

Cardiovascular Research

Volumn 62, Issue 2, 2004, Pages 309-322

  Rohr, Stephan ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Gap junction; Heart; Impulse propagation; Sodium channels; Tissue structure

Indexed keywords

CONNEXIN 43; SODIUM CHANNEL;

CELL ACTIVATION; CELL SIZE; CHANNEL GATING; COCULTURE; COMPUTER SIMULATION; ELECTROPHYSIOLOGY; FIBROBLAST; GAP JUNCTION; HEART ARRHYTHMIA; HEART CELL CULTURE; HEART CONDUCTION; HEART DEPOLARIZATION; HEART EXCITATION; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; IMMUNOCYTOCHEMISTRY; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; REVIEW; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HUMANS; ION CHANNEL GATING; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; SODIUM CHANNELS;

EID: 1942438688     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.11.035     Document Type: Review

References (58)

1. Weidmann S. The electrical constants of Purkinje fibres. J. Physiol. (Lond.). 118:1952;348-360.
2. Sjöstrand F.S., Andersson E. Electron microscopy of the intercalated disc of cardiac muscle tissue. Experientia. 1954;10.
3. Weidmann S. The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle. J. Physiol. (Lond.). 187:1966;323-342.
4. Weidmann S. Electrical constants of trabecular muscle from mammalian heart. J. Physiol. (Lond.). 210:1970;1041-1054.
5. Mendez C., Mueller W.J., Urguiaga X. Propagation of impulses across the Purkinje fiber-muscle junctions in the dog heart. Circ. Res. 36:1970;135-150.
6. Overholt E.D., Joyner R.W., Veenstra R.D., Rawling D., Wiedmann R. Unidirectional block between Purkinje and ventricular layers of papillary muscle. Am. J. Physiol. 247:1984;H584-H595.
7. Joyner R.W. Effects of the discrete pattern of electrical coupling on propagation through an electrical syncytium. Circ. Res. 50:1982;192-200.
8. Saffitz J.E., Kanter H.L., Green K.G., Tolley T.K., Beyer E.C. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ. Res. 74:1994;1065-1070.
9. Spach M.S., Heidlage J.F., Dolber P.C., Barr R.C. Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. Circ. Res. 86:2000;302-311.
10. Kléber A.G., Janse M.J., Fast V.G. Normal and abnormal conduction in the heart. Handbook of physiology. The Heart. vol. 1:2001;455-530 Oxford Univ. Press, Oxford.
11. Rudy Y., Quan W. Propagation delays across cardiac gap junctions and their reflection in extracellular potentials: a simulation study. J. Cardiovasc. Electrophysiol. 2:1991;299-315.
12. Shaw R.M., Rudy Y. Ionic mechanisms of propagation in cardiac tissue: roles of the sodium and L-type calcium currents during reduced excitability and decreased gap-junction coupling. Circ. Res. 81:1997;727-741.
13. Rohr S., Schölly D.M., Kleber A.G. Patterned growth of neonatal rat heart cells in culture. Morphological and electrophysiological characterization. Circ. Res. 68:1991;114-130.
14. Rohr S., Flückiger-Labrada R., Kucera J.P. Photolithographically defined deposition of attachment factors as a versatile method for patterning the growth of different cell types in culture. Pflugers Arch.-Eur. J. Physiol. 446:2003;125-132.
15. Rohr S., Kucera J.P. Optical recording system based on a fiber optic image conduit: assessment of microscopic activation patterns in cardiac tissue. J. Biophys. 75:1998;1062-1075.
16. Rohr S., Salzberg B.M. Discontinuities in action potential propagation along chains of single ventricular myocytes in culture: multiple site optical recording of transmembrane voltage (MSORTV) suggests propagation delays at the junctional sites between cells. Biol. Bull. Mar. Biol. Lab. 183:1992;342-343.
17. Fast V.G., Kléber A.G. Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes. Circ. Res. 73:1993;914-925.
18. Rohr S., Kucera J.P., Kléber A.G. Slow conduction in cardiac tissue: I. Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ. Res. 83:1998;781-794.
19. De Bakker J.M.T., Van Capelle F.J.L., Janse M.J.et al. Slow conduction in the infarcted human heart - zigzag course of activation. Circle. 88:1993;915-926.
20. Spach M.S., Dolber P.C., Heidlage J.F. Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ. Res. 62:1988;811-832.
21. Kléber A.G., Janse M.J., Wilms-Schopmann F.J.G., Wilde A.A.M., Coronel R. Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. Circle. 73:1986;189-198.
22. Hisatome I., Arita M. Effects of catecholamines on the residual sodium channel dependent slow conduction in guinea pig ventricular muscles under normoxia and hypoxia. Cardiovasc. Res. 29:1995;65-73.
23. Kagiyama Y., Hill J.L., Gettes L.S. Interaction of acidosis and increased extracellular potassium on action potential characteristics and conduction in guinea pig ventricular muscle. Circ. Res. 51:1982;614-623.
24. Shaw R.M., Rudy Y. Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ. Res. 80:1997;124-138.
25. Cole W.C., Piccone J.B., Sperelakis N. Gap junction uncoupling and discontinuous propagation in the heart. Biophys. J. 53:1988;809-818.
26. Vaidya D., Tamaddon H.S., Lo C.W.et al. Null mutation of connexin 43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ. Res. 88:2001;1196-1202.
27. Fast V.G., Kléber A.G. Block of impulse propagation at an abrupt tissue expansion: evaluation of the critical strand diameter in 2- and 3-dimensional computer models. Cardiovasc. Res. 30:1995;449-459.
28. Leon L.J., Roberge F.A. Directional characteristics of action potential propagation in cardiac muscle. A model study. Circ. Res. 69:1991;378-395.
29. Rohr S., Kucera J.P., Fast V.G., Kléber A.G. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science. 275:1997;841-844.
30. Ursell P.C., Gardner P.I., Albala A., Fenoglio J.J. Jr., Wit A.L. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ. Res. 56:1985;436-451.
31. Spach M.S., Dolber P.C. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ. Res. 58:1986;356-371.
32. Yao J., Hussain W., Patel P., Peters N.S., Boyden P.A., Wit A.L. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circ. Res. 92:2003;437-443.
33. Henriquez A.P., Vogel R., Muller-Borer B.J., Henriquez C.S., Weingart R., Cascio W.E. Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophys. J. 81:2001;2112-2121.
34. Xianming L., Crye M., Veenstra R.D. Regulation of connexin43 gap junctional conductance by ventricular action potentials. Circ. Res. 93:2003;e63-e73.
35. Bukauskas F.F., Elfgang C., Willecke K., Weingart R. Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. Biophys. J. 68:1995;2289-2298.
36. Manabe I., Takayuki S., Nagai R. Gene expression in fibroblasts and fibrosis. Circ. Res. 91:2002;1103-1113.
37. Spach M.S., Boineau J.P. Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias. Pacing Clin. Electrophysiol. 20:1997;397-413.
38. Hyde A., Blondel B., Matter A., Cheneval J.P., Filloux B., Girardier L. Homo- and heterocellular junctions in cell cultures: an electrophysiological and morphological study. Prog. Brain Res. 31:1969;283-311.
39. Goshima K. Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture. Exp. Cell Res. 58:1969;420-426.
40. Feld Y., Melamed-Frank M., Kehat I., Tal D., Marom S., Gepstein L. Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability. Circle. 105:2002;522-529.
41. Rohr S., Salzberg B.M. Multiple site optical recording of transmembrane voltage in patterned growth heart cell cultures: assessing electrical behavior, with microsecond resolution, on a cellular and subcellular scale. Biophys. J. 67:1994;1301-1315.
42. Fast V.G., Darrow B.J., Saffitz J.E., Kléber A.G. Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping: role of tissue discontinuities. Circ. Res. 79:1996;115-127.
43. Gaudesius G., Miragoli M., Thomas S.P., Rohr S. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ. Res. 93:2003;421-428.
44. De Maziere A.M.G.L., Van Ginneken A.C.G., Wilders R., Jongsma H.J., Bouman L.N. Spatial and functional relationship between myocytes and fibroblasts in the rabbit sinoatrial node. J. Mol. Cell. Cardiol. 24:1992;567-578.
45. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol. Rev. 79:1999;215-262.
46. Weber K. Cardiac interstitium. Poole-Wilson P., Colucci W., Massie B., Chatterjee K., Coats A. Heart failure. 1997;13-31 Churchill Livingstone, New York (NY).
47. Jamieson S., Going J.J., D'Arcy R., George W.D. Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours. J. Pathol. 184:1998;37-43.
48. Spanakis S.G., Petridou S., Masur S.K. Functional gap junctions in corneal fibroblasts and myofibroblasts. Invest. Ophthalmol. Vis. Sci. 39:1998;1320-1328.
49. Cohen S.A. Immunocytochemical localization of rH1 sodium channels in adult rat heart atria and ventricle. Presence in terminal intercalated discs. Circle. 94:1994;3083-3086.
50. Rohr S., Flückiger R., Cohen S.A. Immunocytochemical localization of sodium and calcium channels in cultured neonatal rat ventricular cardiomyocytes. Biophys. J. 76:1999;A366. [Tu-Pos515, abstract].
51. Sperelakis N., McConnell K. An electric field mechanism for transmission of excitation from cell to cell in cardiac muscles and smooth muscles. Res. Adv. Biomed. Eng. 2:2001;39-66.
52. Kucera J., Rohr S., Rudy Y. Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ. Res. 91:2002;1176-1182.
53. Maier S.K.G., Westenbroek R.E., Schenkmann K.A., Feigl E.O., Scheuer T., Catterall W.A. An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc. Natl. Acad. Sci. U. S. A. 99:2002;4073-4078.
54. Sperelakis N., Mann J.E. Evaluation of electric field changes in the cleft between excitable cells. J. Theor. Biol. 64:1977;71-96.
55. Sperelakis N. An electric field mechanism for transmission of excitation between myocardial cells. Circ. Res. 91:2002;985-987. [Editorial].
56. Petrecca K., Atanasiu R., Grinstein S., Orlowski J., Shrier A. Subcellular localization of the Na+/H+ exchanger NHE1 in rat myocardium. Am. J. Physiol. (Heart Circ. Physiol.). 276:1999;H709-H717.
57. Camelliti P., Green C.R., LeGrice I., Kohl P. Fibroblast network in rabbit sinoatrial node. Structural and functional identification of homogeneous and heterogeneous cell coupling. Circ. Res. 2004; doi:10.1161/01.RES.0000122382. 19400.14.
58. Goldsmith E.C., Hoffman A., Morales M.O., Potts J.D., Price R.L., McFadden A., Borg T.K. Organization of fibroblasts in the heart. Dev. Dyn. 2004;. in press.