Remodeling of cardiac gap junctions: The relationship to the genesis of ventricular tachycardia

Journal of Electrocardiology

Volumn 34, Issue SUPPL., 2001, Pages 77-83

  Wit, Andrew L ^a  

^a Surgeons of Columbia University ^*  (United States)

Author keywords

Anisotropy; Conduction; Reentry arrhythmias

Indexed keywords

CONFERENCE PAPER; GAP JUNCTION; HEART CONDUCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE REMODELING; HEART VENTRICLE TACHYCARDIA; HUMAN; HUMAN TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REENTRY ARRHYTHMIA;

EID: 0035698301     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1054/jelc.2001.28834     Document Type: Conference Paper

References (56)

1. Cardiac gap junctions
2. Connections with connexins: The molecular basis of direct intercellular signaling
3. Intercellular junctions and the application of microscopical techniques: The cardiac gap junction as a case model
4. The gap junction communication channel
5. Structure-activity relations of the cardiac gap junction channel
6. Connexins in mammalian heart function
7. Directional differences of impulse spread in trabecular muscle from mammalian heart
8. The functional role of structural complexities in the propagation of depolarization in the atrium of the dog. Cardiac conduction disturbances due to discontinuities of effective axial resistivity
9. Distribution and three-dimensional structure of intercellular junctions in canine myocardium
10. The molecular basis of anisotropy: Role of gap junctions
11. Influence of cardiac fiber orientation on wavefront voltage, conduction velocity and tissue resistivity in the dog
12. The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conduction
13. Anisotropic conduction in monolayers of neonatal heart cells cultured on a collagen substrate
14. The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents
15. Discontinuous anisotropic propagation
16. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts
17. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age
18. Anisotropic reentry in the epicardial border zone of myocardial infarcts
19. Structural and electrophysiological changes in the epicardial border zone of myocardial infarcts during infarct healing
20. Influences of anisotropic tissue structure on reentrant ventricular tachycardia
21. Anisotropic reentry: A model of arrhythmias that may necessitate a new approach to antiarrhythmic drug development
22. Reentrant ventricular arrhythmias in the late myocardial infarction period. I. Conduction characteristics in the infarction zone
23. Reentrant ventricular arrhythmias in the late MI period in the dog. 13 Correlation of activation and refractory maps
24. The figure 8 model of reentrant excitation in the canine post-infarction heart
25. Characteristics of the temporal and spatial excitable gap in anisotropic reentrant circuits causing sustained ventricular tachycardia
26. Fractionated electrical activity and continuous electrical activity: Fact or artifact?
27. Functional role of the epicardium in postinfarction ventricular tachycardia. Observations derived from computerized epicardial activation mapping, entrainment, and epicardial laser photoablation
28. Remodeling of ventricular conduction pathways in healed canine infarct border zones
29. Disturbed connexin43 gap junction distribution correlate with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia
30. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy
31. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts
32. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction
33. Conduction disturbances and increased atrial vulnerability in connexin-40-deficient mice analyzed by transesophageal stimulation
34. Cardiac myocytes express multiple gap junction proteins
35. Multiple connexins colocalize in canine ventricular myocyte gap junctions
36. Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle
37. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions
38. Electrical properties of gap junctional channels in guinea-pig ventricular cell pairs revealed by exposure to heptanol
39. Effects of cellular uncoupling on conduction in anisotropic canine ventricular myocardium
40. Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
41. Differential effects of heptanol, potassium and tetrodotoxin on reentrant ventricular tachycardia around a fixed obstacle in anisotropic myocardium
42. Reentrant circuits and the effects of heptanol in a rabbit model of infarction with a uniform anisotropic epicardial border zone
43. Effects of cellular uncoupling by heptanol on conduction in infarcted myocardium
44. Blocking and modifying actions of octanol on Na channels in frog myelinated nerve
45. n-Alkanols potentiate sodium channel inactivation in squid giant axons
46. Volatile anesthetics block intercellular communication between neonatal rat myocardial cells
47. Structure-activity relationship of the cardiac gap junction channel
48. Voltage-dependent effects of volatile anesthetics on cardiac sodium current
49. 2+ channel current in guinea-pig myocytes
50. Uncoupling of cardiac cells by fatty acids: Structure-activity relationships
51. Slow conduction in cardiac tissue I. Effects of reduction of excitability versus a reduction in electrical coupling on microconduction
52. Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure
53. A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridine
54. New mechanism of antiarrhythmic drug action; increasing L-type calcium current prevents reentrant ventricular tachycardia in the infarcted canine heart
55. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts
56. Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes