β-Lapachone analogs with enhanced antiproliferative activity

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 264-274

  Ríos Luci, Carla ^a   Bonifazi, Evelyn L ^b   León, Leticia G ^a   Montero, Juan C ^c   Burton, Gerardo ^b   Pandiella, Atanasio ^c   Misico, Rosana I ^b   Padrón, José M ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Lapachone; Antitumor agents; Cell cycle; Naphthoquinone; Structure activity relationships

Indexed keywords

2 HYDROXY 5 METHOXY 3 (3 METHYLBUT 2 ENYL)NAPHTHALENE 1,4 DIONE (5 METHOXYLAPACHOL); 2 HYDROXY 7 METHOXYNAPHTHALENE 1,4 DIONE (2 HYDROXY 7 METHOXY 1,4 NAPHTHOQUINONE; 3 HYDROXY 6 METHOXY 2 (3 METHYLBUT 2 EN 1 YL)NAPHTHALENE 1,4 DIONE (7 METHOXYLAPACHOL); 3,4 DIHYDRO 10 HYDROXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,6 DIONE (10 HYDROXY BETA LAPACHONE); 3,4 DIHYDRO 10 METHOXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,6 DIONE (10 METHOXY BETA LAPACHONE); 3,4 DIHYDRO 6 HYDROXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,10 DIONE (6 HYDROXY ALPHA LAPACHONE); 3,4 DIHYDRO 6 HYDROXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,10 DIONE (6 METHOXY ALPHA LAPACHONE); 3,4 DIHYDRO 7 HYDROXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,6 DIONE (7 HYDROXY BETA LAPACHONE); 3,4 DIHYDRO 7 METHOXY 2,2 DIMETHYL 2H BENZO[H]CHROMENE 5,6 DIONE (7 METHOXY BETA LAPACHONE); 3,4 DIHYDRO 8 HYDROXY 2,2 DIMETHYL 2H BENZO[H]CHROMENE 5,6 DIONE (8 HYDROXY BETA LAPACHONE); 3,4 DIHYDRO 8 METHOXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,10 DIONE (8 METHOXY ALPHA LAPACHONE); 3,4 DIHYDRO 8 METHOXY 2,2 DIMETHYL 2H BENZO[H]CHROMENE 5,6 DIONE (8 METHOXY BETA LAPACHONE); 3,4 DIHYDRO 9 HYDROXY 2,2 DIMETHYL 2H BENZO[G]CHROMENE 5,10 DIONE (9 HYDROXY ALPHA LAPACHONE); 3,4,5,6 TETRAHYDRO 2,2 DIMETHYL 5,6 DIOXO 2H BENZO[H]CHROMEN 7 YL PIVALATE (7 PIVALOYL BETA LAPACHONE); 7 HYDROXY BETA LAPACHONE; ALPHA LAPACHONE; ANTINEOPLASTIC AGENT; BENZENE; BETA LAPACHONE; HYDROXYL GROUP; ISOMERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE; CYCLIZATION; CYTOTOXICITY; DNA DAMAGE; DRUG SYNTHESIS; PROTEIN EXPRESSION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES; HUMANS; NAPHTHOQUINONES; REACTIVE OXYGEN SPECIES; TOPOISOMERASE INHIBITORS;

EID: 84861635400     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.008     Document Type: Article

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