Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives α-lapachone and β-lapachone

Cancer Chemotherapy and Pharmacology

Volumn 47, Issue 3, 2001, Pages 187-198

  Krishnan, P ^a   Bastow, K F ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Catalytic inhibitors; DNA topoisomerase II; Naphthoquinones

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ALPHA LAPACHONE; ANTIOXIDANT; BETA LAPACHONE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; ENDONUCLEASE; PYRANONAPHTHOQUINONE DERIVATIVE; UNCLASSIFIED DRUG; ALPHA-LAPACHONE; BETA-LAPACHONE; ENZYME INHIBITOR; ETOPOSIDE; NAPHTHOQUINONE; NUCLEIC ACID SYNTHESIS INHIBITOR;

ARTICLE; CANCER CELL CULTURE; CATALYSIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NASOPHARYNX TUMOR; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; CELL CULTURE; CLONOGENIC ASSAY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; OXIDATIVE STRESS; PHYSIOLOGY;

COLONY-FORMING UNITS ASSAY; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; ENZYME ACTIVATION; ENZYME INHIBITORS; ETOPOSIDE; NAPHTHOQUINONES; NUCLEIC ACID SYNTHESIS INHIBITORS; OXIDATIVE STRESS; TUMOR CELLS, CULTURED;

EID: 0034743360     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800000221     Document Type: Article

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