Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 6110-6120

  Wang, Wen Long ^a   Chai, Sergio C ^a   Huang, Min ^b   He, Hong Zhen ^a   Hurley, Thomas D ^a   Ye, Qi Zhuang ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 METHYLTHIOPHEN 2 YL)BENZENE 1,2 DIOL; ANTIINFECTIVE AGENT; CATECHOL; IRON; METAL ION; METHIONINE; METHIONINE AMINOPEPTIDASE INHIBITOR; METHIONYL AMINOPEPTIDASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BACTERIAL CELL; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH THROUGHPUT SCREENING; NONHUMAN; PROTEIN EXPRESSION;

AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; IRON; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53549126384     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8005788     Document Type: Article

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