Structure-activity relationship analysis of the peptide deformylase inhibitor 5-bromo-1H-indole-3-acetohydroxamic acid

ChemMedChem

Volumn 4, Issue 2, 2009, Pages 261-275

  Petit, Sylvain ^a,b   Duroc, Yann ^b   Larue, Valéry ^c   Giglione, Carmela ^b   Léon, Carole ^a   Soulama, Coralie ^d   Denis, Alexis ^d   Dardel, Frederic ^c   Meinnel, Thierry ^b   Artaud, Isabelle ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT DES SCIENCES DU VÉGÉTAL   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d NONE   (France)

Author keywords

Antibiotics; Indoles; Inhibitors; Nmr spectroscopy; Peptide deformylase

Indexed keywords

(1 BENZOTRIAZOL 1 YLMETHYL 5 BROMOINDOL 3 YL)ACETIC ACID ETHYL ESTER; (1 BENZYL 5 BROMOINDOL 3 YL)ACETIC ACID ETHYL ESTER; (3 BENZYL 5 BROMOINDOL 1 YL)ACETIC ACID ETHYL ESTER; (5 BROMO 1 ISOBUTYLINDOL 3 YL)ACETIC ACID ETHYL ESTER; (5 BROMO 1 METHYL INDOL 3 YL)ACETIC ACID ETHYL ESTER; (5 BROMO 1 PHENETHYLINDOL 3 YL)ACETIC ACID ETHYL ESTER; (5 BROMO 1H INDOL 3 YL)ACETIC ACID ETHYL ESTER; (5 BROMO 1H INDOL 3 YL)PHENYLMETHANONE; (5 BROMOINDOL 1 YL)ACETIC ACID ETHYL ESTER; (5 CHLORO 1H INDAZOL 3 YL)ACETIC ACID; (5 CYCLOPROPYL 1H INDOL 3 YL)ACETIC ACID; (5 CYCLOPROPYL 1H INDOL 3 YL)OXOACETIC ACID; (5 METHYL 1H INDOL 3 YL)ACETIC ACID; (5 METHYL 1H INDOL 3 YL)OXOACETIC ACID; (5 METHYLSULFANYL 1H INDOL 3 YL)ACETIC ACID; (5 METHYLSULFANYL 1H INDOL 3 YL)OXOACETIC ACID; 2 (5 BROMO 1H INDOL 3 YL) 1 (2 METHOXYPHENYL)ETHANONE; 2 (5 BROMO 1H INDOL 3 YL) 1 PHENYLETHANONE; 3 BENZYL 5 BROMO 1H INDOLE; 5 BROMO 1H INDOL 3 ACETOHYDROXAMIC ACID; 5 BROMO 1H INDOLE 3 CARBALDEHYDE; 5 BROMO 3 METHYL 1H INDOLE; 5 BROMOINDOLE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 5 CYCLOPROPYL 1H INDOLE; 5 METHYLSULFANYL 1H INDOLE; [5 BROMO 1 (2 ETHYLBUTYL)INDOL 3 YL]ACETIC ACID ETHYL ESTER; [5 BROMO 1 (3 METHYLBUTYL)INDOL 3 YL]ACETIC ACID ETHYL ESTER; INDOLE DERIVATIVE; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; HYDROXAMIC ACIDS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60849094467     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800251     Document Type: Article

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