Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6757-6767

  Huang, Qingqing ^a   Mao, Jialin ^a   Wan, Baojie ^a   Wang, Yuehong ^a   Brun, Reto ^b   Franzblau, Scott G ^a   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

(2 CHLOROPHENYL)[[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]ACETIC ACID METHYLESTER; (4 HYDROXYPHENYL)[[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]ACETIC ACID METHYLESTER; (4 METHOXYPHENYL)[[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]ACETIC ACID METHYLESTER; 2 [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO] 3 PHENYLPROPIONIC ACID METHYLESTER; 2 [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO] 4 METHYLSULFANYLBUTYRIC ACID METHYLESTER; 2 [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]BENZOIC ACID METHYLESTER; 2 METHYLBENZOTHIAZOLE DERIVATIVE; 3 METHYL 2 [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]BUTYRIC ACID METHYLESTER; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID BENZYLAMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID DIETHYLAMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID DIMETHYLAMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID HYDROXYAMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID(2 HYDROXY 1 PHENYLETHYL)AMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID(HYDROXYCARBAMOYLPHENYLMETHYL)AMIDE; 5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID[2 OXO 1 PHENYL 2 [N'(PYRIDINE 4 CARBONYL)HYDRAZINO]ETHYL]AMIDE; [5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOL 3 YL](4 METHYLPIPERAZIN 1 YL)METHANONE; [5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOL 3 YL]MORPHOLIN 4 YLMETHANONE; [5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOL 3 YL]PIPERAZIN 1 YLMETHANONE; [5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOL 3 YL]PIPERIDIN 1 YLMETHANONE; [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]PHENYLACETIC ACID; [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]PHENYLACETIC ACID METHYLESTER; BENZOTHIAZOLE DERIVATIVE; METHYL 2 [[5 (2 METHYLBENZOTHIAZOL 5 YLOXYMETHYL)ISOXAZOLE 3 CARBONYL]AMINO]PENTANOIC ACID METHYLESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; TUBERCULOSIS; VERO CELL;

ANTIMALARIALS; ANTITUBERCULAR AGENTS; BENZOTHIAZOLES; DRUG DESIGN; ISOXAZOLES; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PHENYLACETATES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

EID: 71049161722     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901112f     Document Type: Article

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