Elucidation of Mycobacterium tuberculosis TypeII Dehydroquinase Inhibitors using a Fragment Elaboration Strategy

ChemMedChem

Volumn 7, Issue 6, 2012, Pages 1031-1043

  Tran, Anh Thu ^a   West, Nicholas P ^b   Britton, Warwick J ^b   Payne, Richard J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Antibiotics; Dehydroquinases; Inhibitors; Medicinal chemistry; Mycobacterium tuberculosis

Indexed keywords

1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (2 FLUOROPHENOXY)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (3 NITROPHENOXY)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (NAPHTHALEN 1 YLOXY)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (NAPHTHALEN 2 YLOXY)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (NAPHTHALEN 2 YLTHIO)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 (PHENYLTHIO)ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [(4 FLUOROPHENYL)THIO]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [(4,5 DIPHENYLOXAZOL 2 YL)THIO]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [2 (ISOXAZOL 5 YL)PHENOXY]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [2 (TRIFLUOROMETHYL)PHENYLTHIO]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [3 (NAPHTHALEN 2 YL)PHENOXY]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [3 (TRIFLUOROMETHYL)PHENOXY]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 [4 (NAPHTHALEN 2 YL)PHENOXY]ETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 PHENOXYETHANONE; 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 (2 FLUOROPHENOXY)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 (3 NITROPHENOXY)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 (NAPHTHALEN 1 YLOXY)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 (NAPHTHALEN 2 YLOXY)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 (PHENYLTHIO)ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 [3 (TRIFLUOROMETHYL)PHENOXY]ETHANONE; 1 (3,4 DIHYDROXYPHENYL) 2 PHENOXYETHANONE; 1 (3,4 DIHYDROXYPHENYL)ETHANONE; 2 (BENZO[D]THIAZOL 2 YLTHIO) 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL)ETHANONE; 2 [(4 CHLOROPHENYL)THIO] 1 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL)ETHANONE; 2 [[2 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 2 OXOETHYL]THIO]QUINAZOLIN 4(3H)ONE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; TYPE II DEHYDROQUINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FRAGMENTATION REACTION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; HYDRO-LYASES; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861563501     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100606     Document Type: Article

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