Synthesis and Evaluation of Potent Ene-yne Inhibitors of TypeII Dehydroquinases as Tuberculosis Drug Leads

ChemMedChem

Volumn 6, Issue 2, 2011, Pages 262-265

  Tran, Anh Thu ^a   Cergol, Katie M ^a   West, Nicholas P ^b,c   Randall, Elizabeth J ^b,c   Britton, Warwick J ^b,c   Bokhari, Syed Ali Imran ^d   Ibrahim, Musadiq ^d   Lapthorn, Adrian J ^d   Payne, Richard J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CENTENARY INSTITUTE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antibiotics; Dehydroquinases; Medicinal chemistry; Mycobacterium tuberculosis; Shikimate pathway

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; 3 DEHYDROQUINATE DEHYDRATASE INHIBITOR; HYDROLYASE INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; CATALYSIS; ENZYME INHIBITORS; HYDRO-LYASES; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS;

EID: 79251555679     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000399     Document Type: Article

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