Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4640-4651

  Nandhikonda, Premchendar ^a   Lynt, Wen Z ^a   McCallum, Megan M ^a   Ara, Tahniyath ^a   Baranowski, Athena M ^a   Yuan, Nina Y ^a   Pearson, Dana ^a   Bikle, Daniel D ^b   Guy, R Kiplin ^c   Arnold, Leggy A ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLYLMETHANAMINE; CARBAMAZEPINE; METHYLAMINE; NUCLEAR RECEPTOR COACTIVATOR; RANITIDINE; RECEPTOR BLOCKING AGENT; STEROID RECEPTOR COACTIVATOR 2 PEPTIDE; UNCLASSIFIED DRUG; VERAPAMIL; VITAMIN D RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; FLUORESCENCE POLARIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

CELL LINE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLES; MEMBRANES, ARTIFICIAL; METHYLAMINES; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COACTIVATOR 3; NUCLEAR RECEPTOR COACTIVATORS; PERMEABILITY; PROTEIN BINDING; RECEPTORS, CALCITRIOL; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRPV CATION CHANNELS;

EID: 84861489999     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300460c     Document Type: Article

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