Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury

Toxicological Sciences

Volumn 127, Issue 2, 2012, Pages 451-462

  Zhang, Youcai ^a   Csanaky, Iván L ^a   Cheng, Xingguo ^a   Lehman McKeeman, Lois D ^a   Klaassen, Curtis D ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Bile acids; Cholestasis; Oatp transporter

Indexed keywords

ALANINE AMINOTRANSFERASE; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 3A11; CYTOCHROME P450 4A14; FARNESOID X RECEPTOR; LIVER PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; NQO1 PROTEIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; TAUROCHOLIC ACID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CHOLESTATIC LIVER INJURY; CONTROLLED STUDY; DISEASE EXACERBATION; EXTRAHEPATIC BILE DUCT OBSTRUCTION; GENE EXPRESSION; GENE TARGETING; HISTOPATHOLOGY; INJURY SEVERITY; LIVER INJURY; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE;

MUS;

EID: 84861476580     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs123     Document Type: Article

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