Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Zhang, Youcai ^a   Limaye, Pallavi B ^a   Lehman McKeeman, Lois D ^b   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; DEOXYCHOLIC ACID; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR RECEPTOR 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1A1; TAURODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; BACTERIAL DNA; OATP1A1 PROTEIN, MOUSE; ORGANIC CATION TRANSPORTER; RIBOSOME DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTEROIDES; BILE ACID METABOLISM; BILE FLOW; BIOTRANSFORMATION; CONJUGATION; CONTROLLED STUDY; DECONJUGATION; DESULFATION; EPIMERIZATION; FECES; FIRMICUTES; INTESTINE FLORA; LARGE INTESTINE; MALE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; SMALL INTESTINE; URINARY EXCRETION; ANIMAL; BACTERIUM; C57BL MOUSE; COMPARATIVE STUDY; CYTOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTESTINE; LIVER; METABOLISM; METABOLOME; MICROBIOLOGY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

BACTEROIDES; FIRMICUTES; MUS;

ANIMALS; BACTERIA; BILE ACIDS AND SALTS; DNA, BACTERIAL; DNA, RIBOSOMAL; FECES; INTESTINES; LIVER; MALE; METABOLOME; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGANIC CATION TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION;

EID: 84859294062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034522     Document Type: Article

References (39)

1. Klaassen CD, Aleksunes LM, (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62: 1-96.
2. Hofmann AF, Hagey LR, (2008) Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 65: 2461-2483.
3. Ley RE, Lozupone CA, Hamady M, Knight R, Gordon JI, (2008) Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol 6: 776-788.
4. Salzman NH, de Jong H, Paterson Y, Harmsen HJ, Welling GW, et al. (2002) Analysis of 16 S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 148: 3651-3660.
5. Amann RI, Binder BJ, Olson RJ, Chisholm SW, Devereux R, et al. (1990) Combination of 16 S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations. Appl Environ Microbiol 56: 1919-1925.
6. Ridlon JM, Kang DJ, Hylemon PB, (2006) Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47: 241-259.
7. Macdonald IA, Hutchison DM, Forrest TP, (1981a) Formation of urso- and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum. J Lipid Res 22: 458-466.
8. MacDonald IA, Roach PD, (1981b) Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim Biophys Acta 665: 262-269.
9. Gopal-Srivastava R, Hylemon PB, (1988) Purification and characterization of bile salt hydrolase from Clostridium perfringens. J Lipid Res 29: 1079-1085.
10. Macdonald IA, Meier EC, Mahony DE, Costain GA, (1976) 3alpha-, 7alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Clostridium perfringens. Biochim Biophys Acta 450: 142-153.
11. Kitahara M, Takamine F, Imamura T, Benno Y, (2000) Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7alpha-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 50 Pt 3: 971-978.
12. Corzo G, Gilliland SE, (1999) Bile salt hydrolase activity of three strains of Lactobacillus acidophilus. J Dairy Sci 82: 472-480.
13. Kawamoto K, Horibe I, Uchida K, (1989) Purification and characterization of a new hydrolase for conjugated bile acids, chenodeoxycholyltaurine hydrolase, from Bacteroides vulgatus. J Biochem 106: 1049-1053.
14. Martoni C, Bhathena J, Urbanska AM, Prakash S, (2008) Microencapsulated bile salt hydrolase producing Lactobacillus reuteri for oral targeted delivery in the gastrointestinal tract. Appl Microbiol Biotechnol 81: 225-233.
15. Takamine F, Imamura T, (1985) 7 beta-dehydroxylation of 3,7-dihydroxy bile acids by a Eubacterium species strain C-25 and stimulation of 7 beta-dehydroxylation by Bacteroides distasonis strain K-5. Microbiol Immunol 29: 1247-1252.
16. Hagenbuch B, Meier PJ, (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609: 1-18.
17. Cheng X, Maher J, Chen C, Klaassen CD, (2005) Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab Dispos 33: 1062-1073.
18. Hagenbuch B, Adler ID, Schmid TE, (2000) Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J 345 Pt 1: 115-120.
19. Zhang Y, Csanaky IL, Lehman-McKeeman LD, Klaassen CD, (2011) Loss of organic anion transporting polypeptide 1a1 increases deoxycholic Acid absorption in mice by increasing intestinal permeability. Toxicol Sci 124: 251-260.
20. Gong LL, Aranibar N, Han YH, Zhang Y, Lecureux L, et al. (2011) Characterization of Organic Anion Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles. Toxicol Sci.
21. Huijghebaert S, Parmentier G, Eyssen H, (1984) Specificity of bile salt sulfatase activity in man, mouse and rat intestinal microflora. J Steroid Biochem 20: 907-912.
22. Eyssen HJ, De Pauw G, Van Eldere J, (1999) Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora. Appl Environ Microbiol 65: 3158-3163.
23. Lepercq P, Gerard P, Beguet F, Raibaud P, Grill JP, et al. (2004) Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human feces. FEMS Microbiol Lett 235: 65-72.
24. Guarner F, Malagelada JR, (2003) Gut flora in health and disease. Lancet 361: 512-519.
25. Kinross JM, von Roon AC, Holmes E, Darzi A, Nicholson JK, (2008) The human gut microbiome: implications for future health care. Curr Gastroenterol Rep 10: 396-403.
26. Robertson DG, Watkins PB, Reily MD, (2011) Metabolomics in toxicology: preclinical and clinical applications. Toxicol Sci 120 (Suppl 1): S146-170.
27. Davis PJ, Gustafson ME, Rosazza JP, (1976) Formation of indole-3-carboxylic acid by Chromobacterium violaceum. J Bacteriol 126: 544-546.
28. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, et al. (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A 106: 3698-3703.
29. Son G, Kremer M, Hines IN, (2010) Contribution of gut bacteria to liver pathobiology. Gastroenterol Res Pract.
30. Riordan SM, McIver CJ, Williams R, (1998) Liver damage in human small intestinal bacterial overgrowth. Am J Gastroenterol 93: 234-237.
31. Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, et al. (2010) Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 8: 292-300.
32. Podschun R, Ullmann U, (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11: 589-603.
33. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, et al. (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102: 11070-11075.
34. Cheng Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, et al. (2008) Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm 5: 77-91.
35. Fisher CD, Lickteig AJ, Augustine LM, Oude Elferink RP, Besselsen DG, et al. (2009) Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. Eur J Pharmacol 613: 119-127.
36. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2: 217-225.
37. Hagenbuch B, Gui C, (2008) Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38: 778-801.
38. Bhathena SJ, Velasquez MT, (2002) Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 76: 1191-1201.
39. Zhang Y, Klaassen CD, (2010) Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res 51: 13.