Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 587-597

  Gong, Lei ^a   Aranibar, Nelly ^a   Han, Yong Hae ^a   Zhang, Youcai ^b   Lecureux, Lloyd ^a   Bhaskaran, Vasanthi ^a   Khandelwal, Purnima ^a   Klaassen, Curtis D ^b   Lehman McKeeman, Lois D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Biotransformation; Knockout; Metabolomic; Toxicokinetics; Uptake; Xenobiotic transporters

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; DIBROMOSULFOPHTHALEIN; DIGOXIN; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; ISETHIONIC ACID; MESSENGER RNA; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A4; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1; TAURINE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HOMOLOGOUS RECOMBINATION; IN VIVO STUDY; LIVER CELL; MALE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; URINARY EXCRETION;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; ESTRADIOL; ESTRONE; FEMALE; GENE DELETION; HEPATOCYTES; HOMOLOGOUS RECOMBINATION; ISETHIONIC ACID; KIDNEY; LIVER; MALE; METABOLOMICS; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS; RNA, MESSENGER; TAURINE; TAUROCHOLIC ACID;

MUS;

EID: 80051676523     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr114     Document Type: Article

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