메뉴 건너뛰기




Volumn 8, Issue , 2012, Pages

Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation

Author keywords

c Fos; Ethyl pyruvate; Inflammatory nociception; PD 98059; Phospho ERK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANALGESIC AGENT; FORMALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

EID: 84861438661     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-40     Document Type: Article
Times cited : (24)

References (66)
  • 1
    • 33947496370 scopus 로고    scopus 로고
    • Ethyl pyruvate: a novel anti-inflammatory agent
    • 10.1111/j.1365-2796.2007.01789.x, 17391109
    • Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med 2007, 261(4):349-362. 10.1111/j.1365-2796.2007.01789.x, 17391109.
    • (2007) J Intern Med , vol.261 , Issue.4 , pp. 349-362
    • Fink, M.P.1
  • 2
    • 77952671610 scopus 로고    scopus 로고
    • The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds
    • 10.1016/j.bcp.2010.03.007, 20230800
    • Kao KK, Fink MP. The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochem Pharmacol 2010, 80(2):151-159. 10.1016/j.bcp.2010.03.007, 20230800.
    • (2010) Biochem Pharmacol , vol.80 , Issue.2 , pp. 151-159
    • Kao, K.K.1    Fink, M.P.2
  • 3
    • 77954558483 scopus 로고    scopus 로고
    • Novel insights for systemic inflammation in sepsis and hemorrhage
    • Cai B, Deitch EA, Ulloa L. Novel insights for systemic inflammation in sepsis and hemorrhage. Mediat Inflamm 2010, 2010:642462.
    • (2010) Mediat Inflamm , vol.2010 , pp. 642462
    • Cai, B.1    Deitch, E.A.2    Ulloa, L.3
  • 4
    • 34748905416 scopus 로고    scopus 로고
    • Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis
    • 10.1097/MPA.0b013e318064678a, 17895847
    • Cheng BQ, Liu CT, Li WJ, Fan W, Zhong N, Zhang Y, Jia XQ, Zhang SZ. Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. Pancreas 2007, 35(3):256-261. 10.1097/MPA.0b013e318064678a, 17895847.
    • (2007) Pancreas , vol.35 , Issue.3 , pp. 256-261
    • Cheng, B.Q.1    Liu, C.T.2    Li, W.J.3    Fan, W.4    Zhong, N.5    Zhang, Y.6    Jia, X.Q.7    Zhang, S.Z.8
  • 5
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • 10.1073/pnas.192222999, 129448, 12209006
    • Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP, Tracey KJ. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002, 99(19):12351-12356. 10.1073/pnas.192222999, 129448, 12209006.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12351-12356
    • Ulloa, L.1    Ochani, M.2    Yang, H.3    Tanovic, M.4    Halperin, D.5    Yang, R.6    Czura, C.J.7    Fink, M.P.8    Tracey, K.J.9
  • 6
    • 26944449700 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain
    • Kim JB, Yu YM, Kim SW, Lee JK. Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 2005, 1060(1-2):188-192.
    • (2005) Brain Res , vol.1060 , Issue.1-2 , pp. 188-192
    • Kim, J.B.1    Yu, Y.M.2    Kim, S.W.3    Lee, J.K.4
  • 7
    • 77449087688 scopus 로고    scopus 로고
    • Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain
    • 10.1007/s12640-009-9075-4, 19636661
    • Kim SW, Jeong JY, Kim HJ, Seo JS, Han PL, Yoon SH, Lee JK. Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain. Neurotox Res 2010, 17(1):39-49. 10.1007/s12640-009-9075-4, 19636661.
    • (2010) Neurotox Res , vol.17 , Issue.1 , pp. 39-49
    • Kim, S.W.1    Jeong, J.Y.2    Kim, H.J.3    Seo, J.S.4    Han, P.L.5    Yoon, S.H.6    Lee, J.K.7
  • 8
    • 77956428420 scopus 로고    scopus 로고
    • Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat
    • 10.1016/j.expneurol.2010.07.013, 2939141, 20670624
    • Moro N, Sutton RL. Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat. Exp Neurol 2010, 225(2):391-401. 10.1016/j.expneurol.2010.07.013, 2939141, 20670624.
    • (2010) Exp Neurol , vol.225 , Issue.2 , pp. 391-401
    • Moro, N.1    Sutton, R.L.2
  • 9
    • 62349126169 scopus 로고    scopus 로고
    • Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: a 31P-nuclear magnetic resonance study
    • 10.1007/s11064-008-9871-x, 18985448
    • Tokumaru O, Kuroki C, Yoshimura N, Sakamoto T, Takei H, Ogata K, Kitano T, Nisimaru N, Yokoi I. Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: a 31P-nuclear magnetic resonance study. Neurochem Res 2009, 34(4):775-785. 10.1007/s11064-008-9871-x, 18985448.
    • (2009) Neurochem Res , vol.34 , Issue.4 , pp. 775-785
    • Tokumaru, O.1    Kuroki, C.2    Yoshimura, N.3    Sakamoto, T.4    Takei, H.5    Ogata, K.6    Kitano, T.7    Nisimaru, N.8    Yokoi, I.9
  • 10
    • 77950515496 scopus 로고    scopus 로고
    • Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model
    • 10.1016/j.bbrc.2010.03.105, 20307492
    • Choi JS, Lee MS, Jeong JW. Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model. Biochem Biophys Res Commun 2010, 394(3):854-858. 10.1016/j.bbrc.2010.03.105, 20307492.
    • (2010) Biochem Biophys Res Commun , vol.394 , Issue.3 , pp. 854-858
    • Choi, J.S.1    Lee, M.S.2    Jeong, J.W.3
  • 11
    • 79960501774 scopus 로고    scopus 로고
    • Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease
    • 10.4049/jimmunol.1100009, 21685323
    • Huh SH, Chung YC, Piao Y, Jin MY, Son HJ, Yoon NS, Hong JY, Pak YK, Kim YS, Hong JK, Hwang O, Jin BK. Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease. J Immunol 2011, 187(2):960-969. 10.4049/jimmunol.1100009, 21685323.
    • (2011) J Immunol , vol.187 , Issue.2 , pp. 960-969
    • Huh, S.H.1    Chung, Y.C.2    Piao, Y.3    Jin, M.Y.4    Son, H.J.5    Yoon, N.S.6    Hong, J.Y.7    Pak, Y.K.8    Kim, Y.S.9    Hong, J.K.10    Hwang, O.11    Jin, B.K.12
  • 12
    • 75949122041 scopus 로고    scopus 로고
    • Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms
    • 10.1016/j.nbd.2009.12.010, 2824008, 20026271
    • Shen H, Hu X, Liu C, Wang S, Zhang W, Gao H, Stetler RA, Gao Y, Chen J. Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiol Dis 2010, 37(3):711-722. 10.1016/j.nbd.2009.12.010, 2824008, 20026271.
    • (2010) Neurobiol Dis , vol.37 , Issue.3 , pp. 711-722
    • Shen, H.1    Hu, X.2    Liu, C.3    Wang, S.4    Zhang, W.5    Gao, H.6    Stetler, R.A.7    Gao, Y.8    Chen, J.9
  • 13
  • 14
    • 67049132380 scopus 로고    scopus 로고
    • Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits
    • 10.1097/ALN.0b013e3181a160d6, 19417608
    • Wang Q, Ding Q, Zhou Y, Gou X, Hou L, Chen S, Zhu Z, Xiong L. Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology 2009, 110(6):1279-1286. 10.1097/ALN.0b013e3181a160d6, 19417608.
    • (2009) Anesthesiology , vol.110 , Issue.6 , pp. 1279-1286
    • Wang, Q.1    Ding, Q.2    Zhou, Y.3    Gou, X.4    Hou, L.5    Chen, S.6    Zhu, Z.7    Xiong, L.8
  • 15
    • 79952620639 scopus 로고    scopus 로고
    • Inhibitory mechanism of MMP-9 gene expression by ethyl pyruvate in lipopolysaccharide-stimulated BV2 microglial cells
    • Lee EJ, Kim HS. Inhibitory mechanism of MMP-9 gene expression by ethyl pyruvate in lipopolysaccharide-stimulated BV2 microglial cells. Neurosci Lett 2011, 493(1-2):38-43.
    • (2011) Neurosci Lett , vol.493 , Issue.1-2 , pp. 38-43
    • Lee, E.J.1    Kim, H.S.2
  • 16
    • 0347758406 scopus 로고    scopus 로고
    • Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells
    • Song M, Kellum JA, Kaldas H, Fink MP. Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. J Pharmacol Exp Ther 2004, 308:307-316.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 307-316
    • Song, M.1    Kellum, J.A.2    Kaldas, H.3    Fink, M.P.4
  • 17
    • 33750604074 scopus 로고    scopus 로고
    • Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
    • 10.1002/jnr.21052, 16958132
    • Cho IH, Kim SW, Kim JB, Kim TK, Lee KW, Han PL, Lee JK. Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Neurosci Res 2006, 84(7):1505-1511. 10.1002/jnr.21052, 16958132.
    • (2006) J Neurosci Res , vol.84 , Issue.7 , pp. 1505-1511
    • Cho, I.H.1    Kim, S.W.2    Kim, J.B.3    Kim, T.K.4    Lee, K.W.5    Han, P.L.6    Lee, J.K.7
  • 18
    • 51349142546 scopus 로고    scopus 로고
    • Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia
    • 10.1016/j.freeradbiomed.2008.06.009, 18625301
    • Kim HS, Cho IH, Kim JE, Shin YJ, Jeon JH, Kim Y, Yang YM, Lee KH, Lee JW, Lee WJ, Ye SK, Chung MH. Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia. Free Radic Biol Med 2008, 45(7):950-963. 10.1016/j.freeradbiomed.2008.06.009, 18625301.
    • (2008) Free Radic Biol Med , vol.45 , Issue.7 , pp. 950-963
    • Kim, H.S.1    Cho, I.H.2    Kim, J.E.3    Shin, Y.J.4    Jeon, J.H.5    Kim, Y.6    Yang, Y.M.7    Lee, K.H.8    Lee, J.W.9    Lee, W.J.10    Ye, S.K.11    Chung, M.H.12
  • 19
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 2002, 22(2):478-485.
    • (2002) J Neurosci , vol.22 , Issue.2 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 20
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • 10.1038/16040, 10570489
    • Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999, 2(12):1114-1119. 10.1038/16040, 10570489.
    • (1999) Nat Neurosci , vol.2 , Issue.12 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 21
    • 23644449569 scopus 로고    scopus 로고
    • The ERK/MAPK pathway, as a target for the treatment of neuropathic pain
    • 10.1517/14728222.9.4.699, 16083338
    • Ma W, Quirion R. The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert Opin Ther Targets 2005, 9(4):699-713. 10.1517/14728222.9.4.699, 16083338.
    • (2005) Expert Opin Ther Targets , vol.9 , Issue.4 , pp. 699-713
    • Ma, W.1    Quirion, R.2
  • 22
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • 10.1038/328632a0, 3112583
    • Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987, 328(6131):632-634. 10.1038/328632a0, 3112583.
    • (1987) Nature , vol.328 , Issue.6131 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 23
    • 62149111152 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats
    • 10.1007/s12031-008-9134-y, 18649147
    • Zhang XJ, Li Z, Chung EK, Zhang HQ, Xu HX, Sung JJ, Bian ZX. Activation of extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J Mol Neurosci 2009, 37(3):274-287. 10.1007/s12031-008-9134-y, 18649147.
    • (2009) J Mol Neurosci , vol.37 , Issue.3 , pp. 274-287
    • Zhang, X.J.1    Li, Z.2    Chung, E.K.3    Zhang, H.Q.4    Xu, H.X.5    Sung, J.J.6    Bian, Z.X.7
  • 24
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytess by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • Zhuang ZY, Gerner P, Woolf CJ, Ji RR. ERK is sequentially activated in neurons, microglia, and astrocytess by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005, 114(1-2):149-159.
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 25
    • 33744511186 scopus 로고    scopus 로고
    • The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
    • Seino D, Tokunaga A, Tachibana T, Yoshiya S, Dai Y, Obata K, Yamanaka H, Kobayashi K, Noguchi K. The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 2006, 123(1-2):193-203.
    • (2006) Pain , vol.123 , Issue.1-2 , pp. 193-203
    • Seino, D.1    Tokunaga, A.2    Tachibana, T.3    Yoshiya, S.4    Dai, Y.5    Obata, K.6    Yamanaka, H.7    Kobayashi, K.8    Noguchi, K.9
  • 26
    • 0043021910 scopus 로고    scopus 로고
    • Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain
    • Galan A, Cervero F, Laird JM. Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain. Brain Res Mol Brain Res 2003, 116(1-2):126-134.
    • (2003) Brain Res Mol Brain Res , vol.116 , Issue.1-2 , pp. 126-134
    • Galan, A.1    Cervero, F.2    Laird, J.M.3
  • 27
    • 63449113568 scopus 로고    scopus 로고
    • MAP kinase and pain
    • 10.1016/j.brainresrev.2008.12.011, 2666786, 19150373
    • Ji RR, Gereau RW, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev 2009, 60(1):135-148. 10.1016/j.brainresrev.2008.12.011, 2666786, 19150373.
    • (2009) Brain Res Rev , vol.60 , Issue.1 , pp. 135-148
    • Ji, R.R.1    Gereau, R.W.2    Malcangio, M.3    Strichartz, G.R.4
  • 29
    • 0026674117 scopus 로고
    • The formalin test: an evaluation of the method
    • 10.1016/0304-3959(92)90003-T, 1454405
    • Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992, 51(1):5-17. 10.1016/0304-3959(92)90003-T, 1454405.
    • (1992) Pain , vol.51 , Issue.1 , pp. 5-17
    • Tjølsen, A.1    Berge, O.G.2    Hunskaar, S.3    Rosland, J.H.4    Hole, K.5
  • 30
    • 0034736219 scopus 로고    scopus 로고
    • Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin
    • 10.1016/S0306-4522(00)00376-6, 11113361
    • Fu KY, Light AR, Maixner W. Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin. Neuroscience 2000, 101(4):1127-1135. 10.1016/S0306-4522(00)00376-6, 11113361.
    • (2000) Neuroscience , vol.101 , Issue.4 , pp. 1127-1135
    • Fu, K.Y.1    Light, A.R.2    Maixner, W.3
  • 31
    • 29144498985 scopus 로고    scopus 로고
    • Fos, nociception and the dorsal horn
    • Coggeshall RE. Fos, nociception and the dorsal horn. Prog Neurobiol 2005, 77(5):299-352.
    • (2005) Prog Neurobiol , vol.77 , Issue.5 , pp. 299-352
    • Coggeshall, R.E.1
  • 32
    • 0028860249 scopus 로고
    • Fos: an immediate-early transcription factor in neurons
    • 10.1002/neu.480260312, 7775973
    • Curran T, Morgan JI. Fos: an immediate-early transcription factor in neurons. J Neurobiol 1995, 26(3):403-412. 10.1002/neu.480260312, 7775973.
    • (1995) J Neurobiol , vol.26 , Issue.3 , pp. 403-412
    • Curran, T.1    Morgan, J.I.2
  • 33
    • 0031985772 scopus 로고    scopus 로고
    • Using c-fos as a neural marker of pain
    • 10.1016/S0361-9230(97)00277-3, 9434195
    • Harris JA. Using c-fos as a neural marker of pain. Brain Res Bull 1998, 45(1):1-8. 10.1016/S0361-9230(97)00277-3, 9434195.
    • (1998) Brain Res Bull , vol.45 , Issue.1 , pp. 1-8
    • Harris, J.A.1
  • 36
    • 0027440776 scopus 로고
    • The regional distribution of extracellularly regulated kinase-1 and - 2 messenger RNA in the adult rat central nervous system
    • 10.1016/0306-4522(93)90371-L, 8255431
    • Thomas KL, Hunt SP. The regional distribution of extracellularly regulated kinase-1 and - 2 messenger RNA in the adult rat central nervous system. Neuroscience 1993, 56(3):741-757. 10.1016/0306-4522(93)90371-L, 8255431.
    • (1993) Neuroscience , vol.56 , Issue.3 , pp. 741-757
    • Thomas, K.L.1    Hunt, S.P.2
  • 37
    • 38049119409 scopus 로고    scopus 로고
    • P38 MAPK, microglial signaling, and neuropathic pain
    • 10.1186/1744-8069-3-33, 2186318, 17974036
    • Ji RR, Suter MR. p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 2007, 3:33. 10.1186/1744-8069-3-33, 2186318, 17974036.
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 38
    • 0141767048 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    • 10.1046/j.1471-4159.2003.01969.x, 12950462
    • Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem 2003, 86(6):1534-1544. 10.1046/j.1471-4159.2003.01969.x, 12950462.
    • (2003) J Neurochem , vol.86 , Issue.6 , pp. 1534-1544
    • Svensson, C.I.1    Marsala, M.2    Westerlund, A.3    Calcutt, N.A.4    Campana, W.M.5    Freshwater, J.D.6    Catalano, R.7    Feng, Y.8    Protter, A.A.9    Scott, B.10    Yaksh, T.L.11
  • 39
    • 78649808560 scopus 로고    scopus 로고
    • Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death
    • 10.1074/jbc.M110.132522, 2998094, 20923777
    • Hong J, Cho IH, Kwak KI, Suh EC, Seo J, Min HJ, Choi SY, Kim CH, Park SH, Jo EK, Lee S, Lee KE, Lee SJ. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem 2010, 285(50):39447-39457. 10.1074/jbc.M110.132522, 2998094, 20923777.
    • (2010) J Biol Chem , vol.285 , Issue.50 , pp. 39447-39457
    • Hong, J.1    Cho, I.H.2    Kwak, K.I.3    Suh, E.C.4    Seo, J.5    Min, H.J.6    Choi, S.Y.7    Kim, C.H.8    Park, S.H.9    Jo, E.K.10    Lee, S.11    Lee, K.E.12    Lee, S.J.13
  • 40
    • 0033577464 scopus 로고    scopus 로고
    • Microglial reactions after subcutaneous formalin injection into the rat hind paw
    • Fu KY, Light AR, Matsushima GK, Maixner W. Microglial reactions after subcutaneous formalin injection into the rat hind paw. Brain Res 1999, 825(1-2):59-67.
    • (1999) Brain Res , vol.825 , Issue.1-2 , pp. 59-67
    • Fu, K.Y.1    Light, A.R.2    Matsushima, G.K.3    Maixner, W.4
  • 41
    • 0023223448 scopus 로고
    • The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
    • 10.1016/0304-3959(87)90088-1, 3614974
    • Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987, 30(1):103-114. 10.1016/0304-3959(87)90088-1, 3614974.
    • (1987) Pain , vol.30 , Issue.1 , pp. 103-114
    • Hunskaar, S.1    Hole, K.2
  • 43
    • 26444558061 scopus 로고    scopus 로고
    • Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
    • 10.1161/01.STR.0000181779.83472.35, 16141417
    • Yu YM, Kim JB, Lee KW, Kim SY, Han PL, Lee JK. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 2005, 36(10):2238-2243. 10.1161/01.STR.0000181779.83472.35, 16141417.
    • (2005) Stroke , vol.36 , Issue.10 , pp. 2238-2243
    • Yu, Y.M.1    Kim, J.B.2    Lee, K.W.3    Kim, S.Y.4    Han, P.L.5    Lee, J.K.6
  • 44
    • 77957941162 scopus 로고    scopus 로고
    • Ethyl pyruvate has antiinflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury
    • 10.3349/ymj.2010.51.6.838, 2995973, 20879048
    • Jang IS, Park MY, Shin IW, Sohn JT, Lee HK, Chung YK. Ethyl pyruvate has antiinflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury. Yonsei Med J 2010, 51(6):838-844. 10.3349/ymj.2010.51.6.838, 2995973, 20879048.
    • (2010) Yonsei Med J , vol.51 , Issue.6 , pp. 838-844
    • Jang, I.S.1    Park, M.Y.2    Shin, I.W.3    Sohn, J.T.4    Lee, H.K.5    Chung, Y.K.6
  • 45
    • 0344861809 scopus 로고    scopus 로고
    • Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers
    • 10.1016/S0014-4886(03)00102-X, 14637089
    • Sorkin LS, Moore J, Boyle DL, Yang L, Firestein GS. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol 2003, 184(1):162-168. 10.1016/S0014-4886(03)00102-X, 14637089.
    • (2003) Exp Neurol , vol.184 , Issue.1 , pp. 162-168
    • Sorkin, L.S.1    Moore, J.2    Boyle, D.L.3    Yang, L.4    Firestein, G.S.5
  • 46
    • 0025014877 scopus 로고
    • The rat paw formalin test: comparison of noxious agents
    • 10.1016/0304-3959(90)90073-M, 2308768
    • Wheeler-Aceto H, Porreca F, Cowan A. The rat paw formalin test: comparison of noxious agents. Pain 1990, 40(2):229-238. 10.1016/0304-3959(90)90073-M, 2308768.
    • (1990) Pain , vol.40 , Issue.2 , pp. 229-238
    • Wheeler-Aceto, H.1    Porreca, F.2    Cowan, A.3
  • 47
    • 77951769250 scopus 로고    scopus 로고
    • Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin
    • Carmichael NM, Dostrovsky JO, Charlton MP. Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin. Pain 2010, 149(2):124-316.
    • (2010) Pain , vol.149 , Issue.2 , pp. 124-316
    • Carmichael, N.M.1    Dostrovsky, J.O.2    Charlton, M.P.3
  • 48
    • 0035371317 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    • Karim F, Wang CC, Gereau RW. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci 2001, 21(11):3771-3779.
    • (2001) J Neurosci , vol.21 , Issue.11 , pp. 3771-3779
    • Karim, F.1    Wang, C.C.2    Gereau, R.W.3
  • 49
    • 33645325812 scopus 로고    scopus 로고
    • Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)
    • Karim F, Hu HJ, Adwanikar H, Kaplan D, Gereau RW. Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK). Mol Pain 2006, 16(2):2.
    • (2006) Mol Pain , vol.16 , Issue.2 , pp. 2
    • Karim, F.1    Hu, H.J.2    Adwanikar, H.3    Kaplan, D.4    Gereau, R.W.5
  • 50
    • 4644312225 scopus 로고    scopus 로고
    • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    • 10.1523/JNEUROSCI.2396-04.2004, 15385614
    • Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C, Befort K, Woolf CJ, Ji RR. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 2004, 24(38):8310-8321. 10.1523/JNEUROSCI.2396-04.2004, 15385614.
    • (2004) J Neurosci , vol.24 , Issue.38 , pp. 8310-8321
    • Kawasaki, Y.1    Kohno, T.2    Zhuang, Z.Y.3    Brenner, G.J.4    Wang, H.5    Van Der Meer, C.6    Befort, K.7    Woolf, C.J.8    Ji, R.R.9
  • 51
    • 18844407004 scopus 로고    scopus 로고
    • Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection
    • Yu YQ, Chen J. Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection. Neurosci Lett 2005, 381(1-2):194-198.
    • (2005) Neurosci Lett , vol.381 , Issue.1-2 , pp. 194-198
    • Yu, Y.Q.1    Chen, J.2
  • 52
    • 4344648261 scopus 로고    scopus 로고
    • Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation
    • Adwanikar H, Karim F, Gereau RW. Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain 2004, 111(1-2):125-135.
    • (2004) Pain , vol.111 , Issue.1-2 , pp. 125-135
    • Adwanikar, H.1    Karim, F.2    Gereau, R.W.3
  • 53
    • 21844449963 scopus 로고    scopus 로고
    • Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
    • 10.1016/j.pain.2005.05.031, 15979799
    • Cruz CD, Neto FL, Castro-Lopes J, McMahon SB, Cruz F. Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats. Pain 2005, 116(3):411-419. 10.1016/j.pain.2005.05.031, 15979799.
    • (2005) Pain , vol.116 , Issue.3 , pp. 411-419
    • Cruz, C.D.1    Neto, F.L.2    Castro-Lopes, J.3    McMahon, S.B.4    Cruz, F.5
  • 54
    • 38949212281 scopus 로고    scopus 로고
    • Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling
    • 10.1002/glia.20623, 18186080
    • Tsuda M, Ueno H, Kataoka A, Tozaki-Saitoh H, Inoue K. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia 2008, 56(4):378-386. 10.1002/glia.20623, 18186080.
    • (2008) Glia , vol.56 , Issue.4 , pp. 378-386
    • Tsuda, M.1    Ueno, H.2    Kataoka, A.3    Tozaki-Saitoh, H.4    Inoue, K.5
  • 55
    • 34548096949 scopus 로고    scopus 로고
    • Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21
    • 10.1523/JNEUROSCI.2209-07.2007, 17699671
    • Zhao P, Waxman SG, Hains BC. Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. J Neurosci 2007, 27(33):8893-8902. 10.1523/JNEUROSCI.2209-07.2007, 17699671.
    • (2007) J Neurosci , vol.27 , Issue.33 , pp. 8893-8902
    • Zhao, P.1    Waxman, S.G.2    Hains, B.C.3
  • 56
    • 0030840882 scopus 로고    scopus 로고
    • Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    • 10.1016/S0304-3959(97)03369-1, 9231865
    • Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 1997, 71(3):225-235. 10.1016/S0304-3959(97)03369-1, 9231865.
    • (1997) Pain , vol.71 , Issue.3 , pp. 225-235
    • Watkins, L.R.1    Martin, D.2    Ulrich, P.3    Tracey, K.J.4    Maier, S.F.5
  • 57
    • 0037705314 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003, 23(10):4017-4022.
    • (2003) J Neurosci , vol.23 , Issue.10 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 58
    • 0036711470 scopus 로고    scopus 로고
    • Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytess in the lumbar spinal dorsal horn and the gracile nucleus
    • Ma W, Quirion R. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytess in the lumbar spinal dorsal horn and the gracile nucleus. Pain 2002, 99(1-2):175-184.
    • (2002) Pain , vol.99 , Issue.1-2 , pp. 175-184
    • Ma, W.1    Quirion, R.2
  • 59
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytess for neuropathic pain development and maintenance
    • 10.1523/JNEUROSCI.5290-05.2006, 16571763
    • Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytess for neuropathic pain development and maintenance. J Neurosci 2006, 26(13):3551-3560. 10.1523/JNEUROSCI.5290-05.2006, 16571763.
    • (2006) J Neurosci , vol.26 , Issue.13 , pp. 3551-3560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6    Decosterd, I.7    Ji, R.R.8
  • 60
    • 78149283821 scopus 로고    scopus 로고
    • Peripheral formalin injury induces 2 stages of microglial activation in the spinal cord
    • 10.1016/j.jpain.2010.01.268, 20488758
    • Li K, Lin T, Cao Y, Light AR, Fu KY. Peripheral formalin injury induces 2 stages of microglial activation in the spinal cord. J Pain 2010, 11(11):1056-1065. 10.1016/j.jpain.2010.01.268, 20488758.
    • (2010) J Pain , vol.11 , Issue.11 , pp. 1056-1065
    • Li, K.1    Lin, T.2    Cao, Y.3    Light, A.R.4    Fu, K.Y.5
  • 61
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • 10.1016/0304-3959(83)90201-4, 6877845
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16(2):109-110. 10.1016/0304-3959(83)90201-4, 6877845.
    • (1983) Pain , vol.16 , Issue.2 , pp. 109-110
    • Zimmermann, M.1
  • 63
    • 0346094286 scopus 로고    scopus 로고
    • Subcutaneous administration of botulinum toxin A reduces formalin-induced pain
    • Cui M, Khanijou S, Rubino J, Aoki KR. Subcutaneous administration of botulinum toxin A reduces formalin-induced pain. Pain 2004, 107(1-2):125-133.
    • (2004) Pain , vol.107 , Issue.1-2 , pp. 125-133
    • Cui, M.1    Khanijou, S.2    Rubino, J.3    Aoki, K.R.4
  • 65
    • 33644993675 scopus 로고    scopus 로고
    • Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    • 10.1016/j.pain.2005.12.023, 16495005
    • Piao ZG, Cho IH, Park CK, Hong JP, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 2006, 121(3):219-231. 10.1016/j.pain.2005.12.023, 16495005.
    • (2006) Pain , vol.121 , Issue.3 , pp. 219-231
    • Piao, Z.G.1    Cho, I.H.2    Park, C.K.3    Hong, J.P.4    Choi, S.Y.5    Lee, S.J.6    Lee, S.7    Park, K.8    Kim, J.S.9    Oh, S.B.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.