Airway remodelling in children with cystic fibrosis

Thorax

Volumn 62, Issue 12, 2007, Pages 1074-1080

  Hilliard, Tom N ^a,b   Regamey, Nicolas ^b   Shute, Janis K ^c   Nicholson, Andrew G ^d   Alton, Eric W F W ^b   Bush, Andrew ^d   Davies, Jane C ^b,d  

^a Royal Hospital for Children   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; COLLAGEN; ELASTIN; GELATINASE B; GLYCOSAMINOGLYCAN;

ADOLESCENT; ARTICLE; BIOPSY; BRONCHOSCOPY; CHILD; CILIARY DYSKINESIA; CLINICAL PRACTICE; COUGHING; CYSTIC FIBROSIS; DEMOGRAPHY; FEMALE; HUMAN; HUMAN TISSUE; INFANT; LUNG INFECTION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; RESPIRATORY TRACT INFLAMMATION;

ADOLESCENT; BIOPSY; BRONCHI; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; CYTOKINES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INFANT; MALE; VITAL CAPACITY;

EID: 36048972322     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2006.074641     Document Type: Article

References (35)

1. Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 2003;168:918-51.
2. Bousquet J, Jeffery PK, Busse WW, et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-45.
3. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001;164:S28-38.
4. Khan TZ, Wagener JS, Bost T, et al. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995;151:1075-82.
5. Hays SR, Ferrando RE, Carter R, et al. Structural changes to airway smooth muscle in cystic fibrosis. Thorax 2005;60:226-8.
6. Durieu I, Peyrol S, Gindre D, et al. Subepithelial fibrosis and degradation of the bronchial extracellular matrix in cystic fibrosis. Am J Respir Crit Care Med 1998;158:580-8.
7. Wojnarowski C, Frischer T, Hofbauer E, et al. Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation. Eur Respir J 1999;14:1136-44.
8. Bartram U, Speer CP. The role of transforming growth factor beta in lung development and disease. Chest 2004;125:754-65.
9. Ratjen F, Hartog CM, Paul K, et al. Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha. Thorax 2002;57:930-4.
10. Sagel SD, Kapsner RK, Osberg I. Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis. Pediatr Pulmonol 2005;39:224-32.
11. Stone PJ, Konstan MW, Berger M, et al. Elastin and collagen degradation products in urine of patients with cystic fibrosis. Am J Respir Crit Care Med 1995;152:157-62.
12. Rahmoune H, Lamblin G, Lafitte JJ, et al. Chondroitin sulfate in sputum from patients with cystic fibrosis and chronic bronchitis. Am J Respir Cell Mol Biol 1991;5:315-20.
13. Ranganathan SC, Dezateux C, Bush A, et al. Airway function in infants newly diagnosed with cystic fibrosis. Lancet 2001;358:1964-5.
14. Ranganathan SC, Stocks J, Dezateux C, et al. The evolution of airway function in early childhood following clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med 2004;169:928-33.
15. Rosenstein BJ, Cutting GR. The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel. J Pediatr 1998;132:589-95.
16. Bush A, Cole P, Hariri M, et al. Primary ciliary dyskinesia: diagnosis and standards of care. Eur Respir J 1998;12:982-8.
17. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995;152:1107-36.
18. Sullivan P, Stephens D, Ansari T, et al. Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. Eur Respir J 1998;12:811-5.
19. Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003;167:78-82.
20. Vignola AM, Riccobono L, Mirabella A, et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 1998;158:1945-50.
21. Mautino G, Capony F, Bousquet J, et al. Balance in asthma between matrix metalloproteinases and their inhibitors. J Allergy Clin Immunol 1999;104:530-3.
22. Bruce MC, Poncz L, Klinger JD, et al. Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis. Am Rev Respir Dis 1985;132:529-35.
23. Huang J, Olivenstein R, Taha R, et al. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 1999;160:725-9.
24. McGowan SE. Extracellular matrix and the regulation of lung development and repair. FASEB J 1992;6:2895-904.
25. Parameswaran K, Radford K, Zuo J, et al. Extracellular matrix regulates human airway smooth muscle cell migration. Eur Respir J 2004;24:545-51.
26. Barbato A, Turato G, Baraldo S, et al. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 2003;168:798-803.
27. Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722-7.
28. Vignola AM, Chanez P, Chiappara G, et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997;156:591-9.
29. Redington AE, Madden J, Frew AJ, et al. Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 1997;156:642-7.
30. Drumm ML, Konstan MW, Schluchter MD, et al. Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med 2005;353:1443-53.
31. Milanese M, Crimi E, Scordamaglia A, et al. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol 2001;91:1035-40.
32. Zihlif N, Paraskakis E, Lex C, et al. Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia. Pediatr Pulmonol 2005;39:551-7.
33. Taube C, Duez C, Cui ZH, et al. The role of IL-13 in established allergic airway disease. J Immunol 2002;169:6482-9.
34. Noah TL, Black HR, Cheng PW, et al. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. J Infect Dis 1997;175:638-47.
35. Bonfield TL, Panuska JR, Konstan MW, et al. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 1995;152:2111-8.