메뉴 건너뛰기




Volumn 4, Issue 2, 2009, Pages

CFTR is a negative regulator of NFκB mediated innate immune response

Author keywords

[No Author keywords available]

Indexed keywords

CFTR 172 INHIBITOR; CHLORIDE CHANNEL BLOCKING AGENT; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LUCIFERASE; PROTEIN INHIBITOR; PSEUDOMONAS AERUGINOSA LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

EID: 84864288310     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004664     Document Type: Article
Times cited : (139)

References (43)
  • 3
    • 4644313798 scopus 로고    scopus 로고
    • Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered
    • Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, et al. (2004) Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol 11: 819-824.
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 819-824
    • Zaman, M.M.1    Gelrud, A.2    Junaidi, O.3    Regan, M.M.4    Warny, M.5
  • 4
    • 0023505508 scopus 로고
    • Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines
    • Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, et al. (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A 84: 9233-9237.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9233-9237
    • Yoshimura, T.1    Matsushima, K.2    Tanaka, S.3    Robinson, E.A.4    Appella, E.5
  • 5
    • 0026681802 scopus 로고
    • Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
    • Nakamura H, Yoshimura K, McElvaney NG, Crystal RG (1992) Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 89: 1478-1484.
    • (1992) J Clin Invest , vol.89 , pp. 1478-1484
    • Nakamura, H.1    Yoshimura, K.2    McElvaney, N.G.3    Crystal, R.G.4
  • 6
    • 0027481059 scopus 로고
    • Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups
    • Donnelly SC, Strieter RM, Kunkel SL, Walz A, Robertson CR, et al. (1993) Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet 341: 643-647.
    • (1993) Lancet , vol.341 , pp. 643-647
    • Donnelly, S.C.1    Strieter, R.M.2    Kunkel, S.L.3    Walz, A.4    Robertson, C.R.5
  • 7
    • 0026583649 scopus 로고
    • Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma
    • Marini M, Vittori E, Hollemborg J, Mattoli S (1992) Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol 89: 1001-1009.
    • (1992) J Allergy Clin Immunol , vol.89 , pp. 1001-1009
    • Marini, M.1    Vittori, E.2    Hollemborg, J.3    Mattoli, S.4
  • 8
    • 0025688896 scopus 로고
    • Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung
    • Standiford TJ, Kunkel SL, Basha MA, Chensue SW, Lynch JP 3rd, et al. (1990) Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest 86: 1945-1953.
    • (1990) J Clin Invest , vol.86 , pp. 1945-1953
    • Standiford, T.J.1    Kunkel, S.L.2    Basha, M.A.3    Chensue, S.W.4    Lynch, J.P.5
  • 9
    • 0029010510 scopus 로고
    • Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
    • Armstrong DS, Grimwood K, Carzino R, Carlin JB, Olinsky A, et al. (1995) Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. Bmj 310: 1571-1572.
    • (1995) Bmj , vol.310 , pp. 1571-1572
    • Armstrong, D.S.1    Grimwood, K.2    Carzino, R.3    Carlin, J.B.4    Olinsky, A.5
  • 11
    • 0028015883 scopus 로고
    • Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
    • Konstan MW, Hilliard KA, Norvell TM, Berger M (1994) Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 150: 448-454.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 448-454
    • Konstan, M.W.1    Hilliard, K.A.2    Norvell, T.M.3    Berger, M.4
  • 12
    • 0028881698 scopus 로고
    • Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8
    • DiMango E, Zar HJ, Bryan R, Prince A (1995) Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 96: 2204-2210.
    • (1995) J Clin Invest , vol.96 , pp. 2204-2210
    • DiMango, E.1    Zar, H.J.2    Bryan, R.3    Prince, A.4
  • 13
    • 0028057272 scopus 로고
    • Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro
    • Massion PP, Inoue H, Richman-Eisenstat J, Grunberger D, Jorens PG, et al. (1994) Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J Clin Invest 93: 26-32.
    • (1994) J Clin Invest , vol.93 , pp. 26-32
    • Massion, P.P.1    Inoue, H.2    Richman-Eisenstat, J.3    Grunberger, D.4    Jorens, P.G.5
  • 14
    • 33847052491 scopus 로고    scopus 로고
    • CFTR is a modulator of airway inflammation
    • Rubin BK (2007) CFTR is a modulator of airway inflammation. Am J Physiol Lung Cell Mol Physiol 292: L381-382.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L381-382
    • Rubin, B.K.1
  • 15
    • 0038467574 scopus 로고    scopus 로고
    • A scientific koan: What is the cause of cystic fibrosis?
    • Rubin BK (2003) A scientific koan: what is the cause of cystic fibrosis? Chest 123: 1792-1793.
    • (2003) Chest , vol.123 , pp. 1792-1793
    • Rubin, B.K.1
  • 16
    • 33746583563 scopus 로고    scopus 로고
    • Innate immune response in CF airway epithelia: Hyperinflammatory?
    • Machen TE (2006) Innate immune response in CF airway epithelia: hyperinflammatory? Am J Physiol Cell Physiol 291: C218-230.
    • (2006) Am J Physiol Cell Physiol , vol.291 , pp. C218-230
    • Machen, T.E.1
  • 17
    • 33645454457 scopus 로고    scopus 로고
    • Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta
    • Tseng J, Do J, Widdicombe JH, Machen TE (2006) Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta. Am J Physiol Cell Physiol 290: C678-690.
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. C678-690
    • Tseng, J.1    Do, J.2    Widdicombe, J.H.3    Machen, T.E.4
  • 18
    • 38549168320 scopus 로고    scopus 로고
    • CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells
    • Vij N, Amoako MO, Mazur S, Zeitlin PL (2008) CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol 38: 176-184.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 176-184
    • Vij, N.1    Amoako, M.O.2    Mazur, S.3    Zeitlin, P.L.4
  • 19
    • 33745190973 scopus 로고    scopus 로고
    • Selective inhibition of endoplasmic reticulumassociated degradation rescues {delta}f508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: THERAPEUTIC IMPLICATIONS
    • Vij N, Fang S, Zeitlin PL (2006) Selective Inhibition of Endoplasmic Reticulumassociated Degradation Rescues {Delta}F508-Cystic Fibrosis Transmembrane Regulator and Suppresses Interleukin-8 Levels: THERAPEUTIC IMPLICATIONS. J Biol Chem 281: 17369-17378.
    • (2006) J Biol Chem , vol.281 , pp. 17369-17378
    • Vij, N.1    Fang, S.2    Zeitlin, P.L.3
  • 21
    • 0032081281 scopus 로고    scopus 로고
    • Activation of NFkappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells
    • DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A (1998) Activation of NFkappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. J Clin Invest 101: 2598-2605.
    • (1998) J Clin Invest , vol.101 , pp. 2598-2605
    • DiMango, E.1    Ratner, A.J.2    Bryan, R.3    Tabibi, S.4    Prince, A.5
  • 22
    • 0031452350 scopus 로고    scopus 로고
    • Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa
    • Heeckeren A, Walenga R, Konstan MW, Bonfield T, Davis PB, et al. (1997) Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J Clin Invest 100: 2810-2815.
    • (1997) J Clin Invest , vol.100 , pp. 2810-2815
    • Heeckeren, A.1    Walenga, R.2    Konstan, M.W.3    Bonfield, T.4    Davis, P.B.5
  • 23
    • 41949134634 scopus 로고    scopus 로고
    • CFTR in a lipid raft-TNFR1 complex modulates gap junctional intercellular communication and IL-8 secretion
    • Dudez T, Borot F, Huang S, Kwak BR, Bacchetta M, et al. (2008) CFTR in a lipid raft-TNFR1 complex modulates gap junctional intercellular communication and IL-8 secretion. Biochim Biophys Acta 1783: 779-788.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 779-788
    • Dudez, T.1    Borot, F.2    Huang, S.3    Kwak, B.R.4    Bacchetta, M.5
  • 25
    • 0034805902 scopus 로고    scopus 로고
    • Dysregulated NF-kappaB activation in cystic fibrosis: Evidence for a primary inflammatory disorder
    • Blackwell TS, Stecenko AA, Christman JW (2001) Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol 281: L69-70.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L69-70
    • Blackwell, T.S.1    Stecenko, A.A.2    Christman, J.W.3
  • 26
    • 0035002033 scopus 로고    scopus 로고
    • Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells
    • Stecenko AA, King G, Torii K, Breyer RM, Dworski R, et al. (2001) Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation 25: 145-155.
    • (2001) Inflammation , vol.25 , pp. 145-155
    • Stecenko, A.A.1    King, G.2    Torii, K.3    Breyer, R.M.4    Dworski, R.5
  • 27
    • 0033831270 scopus 로고    scopus 로고
    • Exaggerated activation of nuclear factor-kappaB and altered IkappaBbeta processing in cystic fibrosis bronchial epithelial cells
    • Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, et al. (2000) Exaggerated activation of nuclear factor-kappaB and altered IkappaBbeta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol 23: 396-403.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 396-403
    • Venkatakrishnan, A.1    Stecenko, A.A.2    King, G.3    Blackwell, T.R.4    Brigham, K.L.5
  • 28
    • 2442652835 scopus 로고    scopus 로고
    • Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells
    • Srivastava M, Eidelman O, Zhang J, Paweletz C, Caohuy H, et al. (2004) Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc Natl Acad Sci U S A 101: 7693-7698.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7693-7698
    • Srivastava, M.1    Eidelman, O.2    Zhang, J.3    Paweletz, C.4    Caohuy, H.5
  • 29
    • 14944344881 scopus 로고    scopus 로고
    • NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa
    • Joseph T, Look D, Ferkol T (2005) NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 288: L471-479.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288 , pp. L471-479
    • Joseph, T.1    Look, D.2    Ferkol, T.3
  • 30
    • 0034816052 scopus 로고    scopus 로고
    • Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl2 channel function
    • Weber AJ, Soong G, Bryan R, Saba S, Prince A (2001) Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl2 channel function. Am J Physiol Lung Cell Mol Physiol 281: L71-78.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L71-78
    • Weber, A.J.1    Soong, G.2    Bryan, R.3    Saba, S.4    Prince, A.5
  • 32
    • 45549093249 scopus 로고    scopus 로고
    • The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response
    • Bartoszewski R, Rab A, Twitty G, Stevenson L, Fortenberry J, et al. (2008) The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response. J Biol Chem 283: 12154-12165.
    • (2008) J Biol Chem , vol.283 , pp. 12154-12165
    • Bartoszewski, R.1    Rab, A.2    Twitty, G.3    Stevenson, L.4    Fortenberry, J.5
  • 33
    • 33847014114 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression
    • Rab A, Bartoszewski R, Jurkuvenaite A, Wakefield J, Collawn JF, et al. (2007) Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression. Am J Physiol Cell Physiol 292: C756-766.
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. C756-766
    • Rab, A.1    Bartoszewski, R.2    Jurkuvenaite, A.3    Wakefield, J.4    Collawn, J.F.5
  • 34
    • 0037076416 scopus 로고    scopus 로고
    • CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation
    • Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerceker AA, et al. (2002) CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci U S A 99: 6907-6912.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6907-6912
    • Schroeder, T.H.1    Lee, M.M.2    Yacono, P.W.3    Cannon, C.L.4    Gerceker, A.A.5
  • 35
    • 0035877054 scopus 로고    scopus 로고
    • Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract
    • Schroeder TH, Reiniger N, Meluleni G, Grout M, Coleman FT, et al. (2001) Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J Immunol 166: 7410-7418.
    • (2001) J Immunol , vol.166 , pp. 7410-7418
    • Schroeder, T.H.1    Reiniger, N.2    Meluleni, G.3    Grout, M.4    Coleman, F.T.5
  • 36
    • 34147134534 scopus 로고    scopus 로고
    • Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor
    • Reiniger N, Lee MM, Coleman FT, Ray C, Golan DE, et al. (2007) Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun 75: 1598-1608.
    • (2007) Infect Immun , vol.75 , pp. 1598-1608
    • Reiniger, N.1    Lee, M.M.2    Coleman, F.T.3    Ray, C.4    Golan, D.E.5
  • 37
    • 55149107169 scopus 로고    scopus 로고
    • Update on gene modifiers in cystic fibrosis
    • Collaco JM, Cutting GR (2008) Update on gene modifiers in cystic fibrosis. Curr Opin Pulm Med 14: 559-566.
    • (2008) Curr Opin Pulm Med , vol.14 , pp. 559-566
    • Collaco, J.M.1    Cutting, G.R.2
  • 39
    • 33750364841 scopus 로고    scopus 로고
    • Gene modifiers of lung disease
    • Knowles MR (2006) Gene modifiers of lung disease. Curr Opin Pulm Med 12: 416-421.
    • (2006) Curr Opin Pulm Med , vol.12 , pp. 416-421
    • Knowles, M.R.1
  • 40
    • 0346103721 scopus 로고    scopus 로고
    • Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation
    • Kowalski MP, Pier GB (2004) Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J Immunol 172: 418-425.
    • (2004) J Immunol , vol.172 , pp. 418-425
    • Kowalski, M.P.1    Pier, G.B.2
  • 41
    • 0027928745 scopus 로고
    • CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells
    • Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, et al. (1994) CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 10: 38-47.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 38-47
    • Cozens, A.L.1    Yezzi, M.J.2    Kunzelmann, K.3    Ohrui, T.4    Chin, L.5
  • 42
    • 0036272055 scopus 로고    scopus 로고
    • Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting
    • Bruscia E, Sangiuolo F, Sinibaldi P, Goncz KK, Novelli G, et al. (2002) Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting. Gene Ther 9: 683-685.
    • (2002) Gene Ther , vol.9 , pp. 683-685
    • Bruscia, E.1    Sangiuolo, F.2    Sinibaldi, P.3    Goncz, K.K.4    Novelli, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.