Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo

Journal of Neuroscience

Volumn 28, Issue 48, 2008, Pages 12798-12807

  Planel, Emmanuel ^a   Krishnamurthy, Pavan ^a   Miyasaka, Tomohiro ^b   Liu, Li ^a   Herman, Mathieu ^a   Kumar, Asok ^c   Bretteville, Alexis ^a   Figueroa, Helen Y ^a   Wai, Haung Yu ^a   Whittington, Robert A ^d   Davies, Peter ^e   Takashima, Akihiko ^f   Nixon, Ralph A ^c   Duff, Karen E ^a  

^a NewYork Presbyterian Hospital   (United States)

^b DOSHISHA UNIVERSITY   (Japan)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Alzheimer's disease; Anesthesia; Hypothermia; Microtubules; Tau phosphorylation; Tubulin

Indexed keywords

TAU PROTEIN; TUBULIN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLYMERIZATION; DISSOCIATION; FEMALE; HYPOTHERMIA; IN VIVO STUDY; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; MOUSE; NEUTROPHIL; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SOMATIC CELL; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; ANESTHETICS; ANIMALS; AXONS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; HYPOTHERMIA, INDUCED; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; PHOSPHORYLATION; PROTEIN BINDING; TAU PROTEINS; TRINUCLEOTIDE REPEATS;

EID: 58149387073     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4101-08.2008     Document Type: Article

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