A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon

PLoS Pathogens

Volumn 8, Issue 4, 2012, Pages

  Ortigoza, Mila Brum ^a   Dibben, Oliver ^a   Maamary, Jad ^a   Martinez Gil, Luis ^a   Leyva Grado, Victor H ^a   Abreu, Pablo ^a   Ayllon, Juan ^a   Palese, Peter ^a   Shaw, Megan L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ASN 2; HEAT SHOCK PROTEIN 27; INTERFERON; OSELTAMIVIR; UNCLASSIFIED DRUG; ASN2 COMPOUND; DNA DIRECTED RNA POLYMERASE; ENZYME INHIBITOR; INDOLE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA A (H1N1); INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; INNATE IMMUNITY; INTERFERON INDUCTION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIROGENESIS; VIRUS INHIBITION; VIRUS REPLICATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DOG; DRUG ANTAGONISM; DRUG EFFECT; HAPLORHINI; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY;

AVES; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; DNA-DIRECTED RNA POLYMERASES; DOGS; ENZYME INHIBITORS; HAPLORHINI; HUMANS; INDOLES; INFLUENZA A VIRUS; INTERFERONS; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; VIRUS REPLICATION;

EID: 84861217426     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002668     Document Type: Article

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