Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17471-17482

  Bhutani, Nidhi ^a,b   Piccirillo, Rosanna ^a   Hourez, Raphael ^a,c   Venkatraman, Prasanna ^a,d   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d Advanced Centre for Treatment Research and Education in Cancer   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT MICE; CELL LINES; CELLULAR ENZYMES; CYSTEINE PROTEASE; CYTOSOLIC ENZYMES; HOST DEFENSE; HUNTINGTIN; POLYGLUTAMINE (POLYQ); PROTEASOMES; SPECIFIC INHIBITORS;

AMINO ACIDS; CELL CULTURE; DEGRADATION; HYDROLYSIS; PEPTIDES;

ENZYMES;

CATHEPSIN L; CATHEPSIN X; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE PROTEINASE; HUNTINGTIN; POLYGLUTAMINE; PROTEINASE INHIBITOR; RNA;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BIOCATALYSIS; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME LOCALIZATION; ENZYME PURIFICATION; EXON; LYSOSOME; MALE; MOUSE; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN HYDROLYSIS; RNA INTERFERENCE; SEQUENCE ANALYSIS; WILD TYPE;

ANIMALS; CATHEPSIN L; CATHEPSIN Z; HEK293 CELLS; HELA CELLS; HUMANS; LYSOSOMES; MICE; MUSCLE, SKELETAL; NEURODEGENERATIVE DISEASES; NIH 3T3 CELLS; PEPTIDES;

EID: 84861213255     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.352781     Document Type: Article

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