Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 5, 2012, Pages 677-685

  Sekimoto, Masashi ^a   Sano, Shinsuke ^a,b   Hosaka, Takuomi ^a,c   Nemoto, Kiyomitsu ^a   Degawa, Masakuni ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SETSUNAN UNIVERSITY   (Japan)

Author keywords

Calcium channel blocker; Chemically activated luciferase expression; Cytochrome P450 3A4; Pregnane X receptor; Vitamin D receptor

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CALCITRIOL; CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450 3A; DEXAMETHASONE; DIHYDROPYRIDINE; HUMAN PLACENTA LACTOGEN; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN; VITAMIN D RECEPTOR;

ARTICLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOCHROME P450 3A GENE; CYTOCHROME P450 3A4 GENE; DRUG STRUCTURE; ENHANCER REGION; ENZYME ACTIVITY; GENE; GENE INDUCTION; GENETIC SCREENING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REPORTER GENE;

ANIMALS; BIOLOGICAL ASSAY; CALCIUM CHANNEL BLOCKERS; CELL LINE; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME ACTIVATORS; GENES, REPORTER; GENETIC VECTORS; HEP G2 CELLS; HUMANS; LUCIFERASES; MICE; PLASMIDS; PROMOTER REGIONS, GENETIC; RATS; RECEPTORS, CALCITRIOL; RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; TRANSFECTION; VITAMIN D;

EID: 84861211362     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.677     Document Type: Article

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