Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization

FEBS Letters

Volumn 586, Issue 10, 2012, Pages 1510-1515

  Zhou, Qiyuan ^a   Chen, Tianji ^a   Ibe, Joyce Christina F ^a   Usha Raj, J ^a   Zhou, Guofei ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Focal adhesion protein; Integrin; von Hippel Lindau protein

Indexed keywords

FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR; INTEGRIN; VON HIPPEL LINDAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL COLONIZATION; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84861192691     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.04.009     Document Type: Article

References (49)

1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M.J. Thun Cancer statistics, 2008 CA Cancer J. Clin. 58 2008 71 96 (Pubitemid 351521864)
2. J.T. Erler, and A.J. Giaccia Lysyl oxidase mediates hypoxic control of metastasis Cancer Res. 66 2006 10238 10241 (Pubitemid 44799737)
3. A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat. Rev. Cancer 2 2002 38 47 (Pubitemid 37328806)
4. H. Peinado, and A. Cano A hypoxic twist in metastasis [comment] Nat. Cell Biol. 10 2008 253 254
5. A.F. Chambers, A.C. Groom, and I.C. MacDonald Dissemination and growth of cancer cells in metastatic sites Nat. Rev. Cancer 2 2002 563 572 (Pubitemid 37328923)
6. K. Pantel, and R.H. Brakenhoff Dissecting the metastatic cascade Nat. Rev. Cancer 4 2004 448 456 (Pubitemid 38745530)
7. G.P. Gupta, and J. Massague Cancer metastasis: building a framework Cell 127 2006 679 695 (Pubitemid 44781029)
8. I.C. MacDonald, A.C. Groom, and A.F. Chambers Cancer spread and micrometastasis development: quantitative approaches for in vivo models BioEssays 24 2002 885 893 (Pubitemid 35180844)
9. J. Zavadil, and E.P. Bottinger TGF-beta and epithelial-to-mesenchymal transitions Oncogene 24 2005 5764 5774
10. J.P. Thiery, and J.P. Sleeman Complex networks orchestrate epithelial-mesenchymal transitions Nat. Rev. Mol. Cell. Biol. 7 2006 131 142 (Pubitemid 43278296)
11. H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 2007 415 428 (Pubitemid 46809165)
12. H. Hugo, M.L. Ackland, T. Blick, M.G. Lawrence, J.A. Clements, E.D. Williams, and E.W. Thompson Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression J. Cell. Physiol. 213 2007 374 383 (Pubitemid 47509716)
13. J.C. Tse, and R. Kalluri Mechanisms of metastasis: epithelial-to- mesenchymal transition and contribution of tumor microenvironment J. Cell. Biochem. 101 2007 816 829 (Pubitemid 47040864)
14. O. Iliopoulos, A. Kibel, S. Gray, and W.G. Kaelin Tumour suppression by the human von Hippel-Lindau gene product Nat. Med. 1 1995 822 826
15. T. Bishop Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans PLoS Biol. 2 2004 e289
16. M. Ivan HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing Science (New York, NY) 292 2001 464 468 (Pubitemid 32335941)
17. P. Jaakkola Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science (New York, NY) 292 2001 468 472 (Pubitemid 32335942)
18. N. Masson, C. Willam, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation EMBO J. 20 2001 5197 5206 (Pubitemid 32910914)
19. C.L. Corless, A.S. Kibel, O. Iliopoulos, and W.G. Kaelin Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues Hum. Pathol. 28 1997 459 464 (Pubitemid 27175087)
20. M. Los, G.H. Jansen, W.G. Kaelin, C.J. Lips, G.H. Blijham, and E.E. Voest Expression pattern of the von Hippel-Lindau protein in human tissues Lab. Invest. 75 1996 231 238 (Pubitemid 26272361)
21. W.L. Ho, J.-W. Chang, R.-C. Tseng, J.-T. Chen, C.-Y. Chen, Y.-S. Jou, and Y.-C. Wang Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer Cancer Detect. Prev. 26 2002 343 349 (Pubitemid 36035379)
22. Q. An Deletion of tumor suppressor genes in Chinese non-small cell lung cancer Cancer Lett. 184 2002 189 195 (Pubitemid 34804504)
23. D.M. Pitterle, E.M. Jolicoeur, and G. Bepler Hot spots for molecular genetic alterations in lung cancer In vivo (Athens, Greece) 12 1998 643 658 (Pubitemid 29011999)
24. G. Zhou, L.A. Dada, N.S. Chandel, K. Iwai, E. Lecuona, A. Ciechanover, and J.I. Sznajder Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein FASEB J. 22 2008 1335 1342 (Pubitemid 351656775)
25. G. Zhou, L.A. Dada, M. Wu, A. Kelly, H. Trejo, Q. Zhou, J. Varga, and J.I. Sznajder Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1 Am. J. Physiol. - Lung Cell. Mol. Physiol. 297 2009 L1120 L1130
26. M.A. Esteban Regulation of E-cadherin expression by VHL and hypoxia-inducible factor Cancer Res. 66 2006 3567 3575
27. A.J. Evans VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP 1 and snail Mol. Cell. Biol. 27 2007 157 169 (Pubitemid 46013241)
28. B. Krishnamachary, D. Zagzag, H. Nagasawa, K. Rainey, H. Okuyama, J.H. Baek, and G.L. Semenza Hypoxia-inducible factor-1-dependent repression of E- cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B Cancer Res. 66 2006 2725 2731
29. M.P. Biju, A.K. Neumann, S.J. Bensinger, R.S. Johnson, L.A. Turka, and V.H. Haase Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes Mol. Cell. Biol. 24 2004 9038 9047 (Pubitemid 39313908)
30. M. Ohh Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein Nature Cell Biol. 2 2000 423 427
31. Q. Zhou Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis FASEB J. 25 2011 3032 3044
32. W.G. Kaelin, and E.R. Maher The VHL tumour-suppressor gene paradigm Trends Genet. 14 1998 423 426 (Pubitemid 28505587)
33. S.K. Harten, D. Shukla, R. Barod, A. Hergovich, M.S. Balda, K. Matter, M.A. Esteban, and P.H. Maxwell Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin Mol. Biol. Cell 20 2009 1089 1101
34. M. Kamada, K. Suzuki, Y. Kato, H. Okuda, and T. Shuin von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility Cancer Res. 61 2001 4184 4189 (Pubitemid 32720988)
35. F.A. Mack, J.H. Patel, M.P. Biju, V.H. Haase, and M.C. Simon Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27 Mol. Cell. Biol. 25 2005 4565 4578 (Pubitemid 40705761)
36. T.N. Seagroves, D.L. Peacock, D. Liao, L.P. Schwab, R. Krueger, C.R. Handorf, V.H. Haase, and R.S. Johnson VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis Am. J. Pathol. 176 2010 2269 2282
37. D. Pfander Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development Development (Cambridge, England) 131 2004 2497 2508 (Pubitemid 38877655)
38. Q. Zhou, T. Chen, J.C.F. Ibe, J.U. Raj, and G. Zhou Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization Cell Cycle (Georgetown, Tex) 10 2011 2233 2234
39. R.O. Hynes A reevaluation of integrins as regulators of angiogenesis Nat. Med. 8 2002 918 921 (Pubitemid 35033683)
40. M. Ohh The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix Mol. Cell 1 1998 959 968 (Pubitemid 128379257)
41. G. Kurban, V. Hudon, E. Duplan, M. Ohh, and A. Pause Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis Cancer Res. 66 2006 1313 1319 (Pubitemid 43259909)
42. N. Tang, F. Mack, V.H. Haase, M.C. Simon, and R.S. Johnson pVHL function is essential for endothelial extracellular matrix deposition Mol. Cell. Biol. 26 2006 2519 2530
43. X.N. Meng Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion Br. J.Cancer 101 2009 327 334
44. J.-M. Shieh Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models PloS One 7 2012 e30240
45. T. Kruewel, S. Schenone, M. Radi, G. Maga, A. Rohrbeck, M. Botta, and J. Borlak Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers PloS One 5 2010 e14143
46. J. Zhao Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid Eur. J. Pharmacol. 589 2008 127 131
47. Y.-C. Fong Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway Lung Cancer (Amsterdam, Netherlands) 64 2009 263 270
48. D. Bourboulia, S. Jensen-Taubman, M.R. Rittler, H.Y. Han, T. Chatterjee, B. Wei, and W.G. Stetler-Stevenson Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment Am. J. Pathol. 179 2011 2589 2600
49. N. Zanesi Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency Cancer Res. 65 2005 6576 6582 (Pubitemid 41060693)